Concern about menstrual status and recurrence

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  • comingtoterms
    comingtoterms Member Posts: 421
    edited August 2012

    Ruby, this is just the information I have been looking for! I can't wait to sit down and really read what these studies are reporting. This is great stuff! Thank you so much for posting! Tammy

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  • purple32
    purple32 Member Posts: 3,188
    edited August 2012

    THX comingtoterms.

    I did not have the ki-67. Weeks after my LX , I called and insisted the test be done.

    I will call my onc soon, but not just yet- going away for  a few days and hoping to put the BC on the back burner ( HA!)

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  • Anonymous
    Anonymous Member Posts: 1,376
    edited August 2012

    You're welcome Comingtoterms, hoping you find the answer your are seeking

    Purple, I hope you have a GRAND time !!

    but don't forget to return, we'll miss you Wink 

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  • purple32
    purple32 Member Posts: 3,188
    edited August 2012
    thx ruby Kiss
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  • comingtoterms
    comingtoterms Member Posts: 421
    edited August 2012

    Great news! This topic is on the slate for the San Antonio Conference this year! Unfortunately, it doesn't look like good news in terms of DFS. Cry

     

    P2-12-24

    Resumption or Persistence of Menstruation after Cytotoxic Chemotherapy Is a Poor Prognostic Factor for Disease Free Survival in Premenopausal Patients with Early Breast Cancer
    Park IH, Han H-S, Lee KS, Kang HS, Lee S, Kim SW, Jung SY, Shin KH, Ro J. National Cancer Center, Goyang, Korea; Chungbuk National University, Korea.

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  • Omaz
    Omaz Member Posts: 5,497
    edited August 2012

    Interesting article - they note that using tamoxifen protects from returning menstruation:

    "Multivariate analysis showed that lack of
    tamoxifen use (hazard ratio 0.4, 95% CI 0.3-0.5, P < 0.001) and
    age <=35 years (hazard ratio 9.5, 95% CI 6.1-14.7, P < 0.001)
    were the most important factors for persistent menstrual cycles
    (supplemental Table S1 is available at Annals of Oncology
    online)"

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  • comingtoterms
    comingtoterms Member Posts: 421
    edited August 2012

    Thanks for that article, Omaz - My periods increased in heaviness while I was on Tamoxifen - it was one reason among many, that I stopped. Tammy

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  • Omaz
    Omaz Member Posts: 5,497
    edited August 2012
    comingtoterms - I copied the sentence from the article that you posted  (c:   tamoxifen is such a mystery to me.
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  • FLislander
    FLislander Member Posts: 243
    edited September 2012

    Hi Tammy

    I've been asking around here about experiences with ooph. I'm 40 with very high ER/PR+ and tamoxifen has not been my friend, emotionally and with VERY heavy period. I think I should o the ooph because I cant take the tamox. Hoping it goes well...

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  • Momine
    Momine Member Posts: 7,859
    edited September 2012

    Comingtoterms, quite frankly, I think you should seriously consider the ooph.

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  • purple32
    purple32 Member Posts: 3,188
    edited September 2012

    What about endometrial ablation?

    Has anyone asked their GYN about it ?
    I am not on tamox. but i had an endo ablation many yrs ago, and it was a pc of cake and all periods stopped.  Aaaah!

    What do the DRS say about using that to prevent endometrial problems caused by tamox ?  I hope this helps someone ...possibly ask your dr ?

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  • comingtoterms
    comingtoterms Member Posts: 421
    edited October 2012

    Hi Purple, I think the problem w ablation is that it does stop the heavy periods but it doesn't lower your estrogen production. That makes it kind of like a band aid - it helps the SEs of Tamoxifen, but doesn't deal w the real problem.  Tammy

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  • CherylinOhio
    CherylinOhio Member Posts: 623
    edited October 2012

    I recently spoke with my breast surgeon about removing my ovaries and having a hx.  I have a consulation scheduled this month to discuss both with my gyn.  If removing the estrogen/hormone producing entities in my body reduce reoccurence risk by any % I am all for it.  I have been in chemo pause since july 2011.  My mom and sister both went through menopause at age 40, I am going to be 42 in janaury so it would have happened anyway.  I will stay on any meds they throw at me and get any surgery that will help.  I also juice veggies and have quit smoking and drinking and exercise a lot more so hopefully the combination of everything will keep me alive longer.

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  • purple32
    purple32 Member Posts: 3,188
    edited October 2012

    I see , comingtoterms.  Makes sense I guess.

    I still would think somebody on tamox would at least ask their GYN about it !

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  • peggy_j
    peggy_j Member Posts: 1,700
    edited October 2012

    ckgrayoh,  my MO's nurse said that removing ovaries would reduce my risk of recurrence by about 40%. My MO also said if I were post-meno now, my risk would be about 1/3 lower than it is now. (I'm highly ER+) This might vary by patient and prognosis, but FYI. 

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