Creation Of Trojan Horse Drug Therapy For Treating BC

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http://www.medicalnewstoday.com/releases/251044.php

Administrative Assistant Inspires Creation Of Trojan Horse Drug Therapy For Treating Breast Cancer

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  • leggo
    leggo Member Posts: 3,293
    edited October 2012

    "Current platinum-based drugs, such as the blockbuster drug cisplatin, do not
    work on the most common and most difficult-to-cure types of cancer, including lung
    and breast".

    Yet it's a common treatment. I'm speechless.

  • jenrio
    jenrio Member Posts: 558
    edited October 2012

    Because BC like lung cancer ovarian cancers don't have many better options, so many women in stage IV make do with the lousy, hardhitting, ineffective, expensive drugs like platinums, and make them blockbuster drugs.  

    It's important for patients to call the BS and say:  forget about marketing/enjoying the billion dollar franchises of ineffective/expensive drugs,  get to work finding better targetting and better effective treatment of stage IVers.   We will just say no to the ineffective drugs like avastin or platinum that often adds just a couple/a few of months.   (of course, for certain patients the response is longer, we need to figure out who these patients are by running clinical trials, but overall, the drugs are not worthless, but not a lot)

    This study is cool though, thanks for sharing cp. 

  • leggo
    leggo Member Posts: 3,293
    edited October 2012

    Please correct me if I`m wrong, but carboplatin seems to be used in cases other than Stage IV.

  • jenrio
    jenrio Member Posts: 558
    edited October 2012

    For lung cancer, carboplatin may be more first-line in nonmetastatic situations.

    For BC, as far as i know, platinum drugs are not used as first line in nonmetastatic/nonrecurrent situations.

    The reason: it's not that effective for stage IVer BC, lung cancer.   so it's used by stage IVers, who ran out of more efffective therapies like taxol, ac.   a minority of patients respond to it at first, then majority of this minority soon develop resistance to it.   Hence the grim stats of stage IV survival for BC or lung cancer.  

  • leggo
    leggo Member Posts: 3,293
    edited October 2012

    Just to satisfy my curiosity, I checked around on the boards. Looks like carbo is indeed a first line chemo in some cases, almost exclusively in combination, but used freely none-the-less. Food for thought.

  • jenrio
    jenrio Member Posts: 558
    edited October 2012

    In combination possibly, or maybe you mean cytoxan?    

    Combination often yields better results than singles.   Taxol and AC are still the workhorse 1st line chemo for BC.  I may be wrong, but i'm really surprised to see any woman treated with carbo before taxol in this day/age, unless she is sensitive or allergic.

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