Really interesting article - especially the part on how cancer happens to metastasize. Its not from the quickly proliferating and growing cells they originally thought, but those cells that are able to adapt to new environments. Interesting given  much chemo recommendation is based on proliferation rate.  Thanks for sharing this interesting article.

The dose-dense chemotherapy protocol is not the same as the low-dose chemotherapy protocol.

Dose-dense chemotherapy shortens the treatment cycle while maintaining roughly the same chemotherapy dosage as conventional chemotherapy (the process reduction of time gap between two regular doses).

Low-dose chemotherapy not only shortens the treatment cycle but lowers the dosage of treatment a patient can withstand during shorten administration of the drugs.

Dose-dense chemotherapy was developed on the theory of cancer cell growth and replication developed in the 1980’s known as the Gompertzian growth curve. Because chemotherapy is most effective when cancer cells are dividing the most rapidly, researchers speculated that timing chemotherapy dosage to attack cancer cells at their earliest stage of growth would yield superior results.

Since the endothelial cells (involved in angiogenesis) are the first in the tumor to undergo cell death (apoptosis), the more frequent, lower-dose therapy can have an impressive anti-angiogenic and anti-tumor effects. Blood vessel cells are less likely than tumor cells to become resistant to chemotherapy and should still be able to shrink tumors by destroying their blood supply.

Adding Avastin, which only goes after VEGF-sensitive cancer cells, you still need to go after other pro-angiogenic factors which can substitute for VEGF: FGF, PDGF, ephrin A1, angioprotein 1, IL-8, etc. And with Taxol promoting an increase of IL-8, how effective is it with Avastin? With the low-dose protocol having an anti-angiogenic effect, you really wouldn't need to add a drug like Avastin into the mix.

http://cancerfocus.org/forum/showthread.php?t=3467 

Wow, thank you jenrio, and also for your comments gpawelski, deserves a bump.

My husband had surgery for bladder cancer, both the bladder and prostate were removed, pathology report showed no sign of any cancer in the prostate, yet that's where the cancer came back (reseeded?) in the prostectomy surgical bed, closest thing to a surgical cut line I imagine as the bladder bag is removed whole. (The Forbes article mentions breast cancer often returning to the original tumour site.)

Kathy