Arimidex + Faslodex for MBC

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jenrio
jenrio Member Posts: 558
edited June 2014 in Clinical Trials, Research News, Podcasts, and Study Results

 

Good news:   Arimidex+Faslodex gives a 6 month survival advantage for MBC patients.  

Bad news: 

"Mehta said the results of the Phase 3 trial are particularly exciting because "these patients have not had a new treatment that gave them an overall survival benefit in more than a decade." 
 
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  • SyrMom
    SyrMom Member Posts: 862
    edited August 2012

    Where could I find this study?  

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  • jenrio
    jenrio Member Posts: 558
    edited August 2012
    http://today.uci.edu/news/2012/08/nr_mehta_120801.php

    http://community.breastcancer.org/forum/8/topic/779881

    This post has more information. The 6 months are overall survival advantage, not that big. The progression free survival advantage for the combo is only 1.5 months.

    Also, there are a lot of points about whether the combo offers advantage for patients who had already failed tamoxifen (similar to faslodex). Overall, not earth-shattering. Hormone positive MBC has not seen big improvement in a decade.

     in 2010-2011, Faslodex had a dosage change with 500 mg proven to be more beneficial than traditional 250mg.

    http://www.ncbi.nlm.nih.gov/pubmed/20855825

    There's also this study that shows Faslodex 250mg + Arimidex does not offer significant advantage over Arimidex alone:

    http://www.ncbi.nlm.nih.gov/pubmed/22370325

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  • SyrMom
    SyrMom Member Posts: 862
    edited August 2012

    jenrio - thank you.

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  • Kudra
    Kudra Member Posts: 85
    edited May 2013

    I'm not sure if this is appropriate for this thread, but I'll just share my experience.

    I'm on 500 mg of Faslodex monthly( started weekly, then every two weeks, then monthly.)

    I also take arimidex daily.

    I have 2 mets to my spine and activity around my pancreas.

    My breast mass was inverting my nipple and became extremely painful.

    My breast mass has gone down 2 centimeters, spine mets have receded with new bone growth.

    There's less activity around my pancreas. I've been on this regiment for 6 months with no prior treatments.

    I am also getting xgeva monthly. I take calcium, magnesium and zinc

    together and vitamin D3.

    My bloodwork is good. I have achiness especially the first week after injections.

    So, body aches that are intermittent and I believe it makes me feel anxiety intermittently.

    That's a tough call because, well, stage 4 breast cancer is obviously stressfull.

    I am thrilled with my onc and treatment so far. I've gained 5 pounds. (Bummer)

    I also get fatigue, but it also is intermittent.

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  • Heidihill
    Heidihill Member Posts: 5,476
    edited May 2013

     Kudra, you'll surpass the six-month timeframe, woohooo!! Great to hear that the combo is working. Hang in there.

    I found exercise helped with the Femara body aches and fatigue.

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  • Kudra
    Kudra Member Posts: 85
    edited June 2013

    Thank you for your response! What kind of exercises are you doing? I have to be mindful of spinal mets.

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