Inflammatory Pathway Spurs ....to Resist HER2-..Treatment
http://www.sciencedaily.com/releases/2012/07/120719132602.htm
Inflammatory Pathway Spurs Cancer Stem Cells to Resist HER2-Targeted Breast Cancer Treatment
Comments
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http://www.uofmhealth.org/news/cancer-stemcell-0719
This points to an IL-6 inhibitor, tocilizumab, used for rheumatoid arthritis, to work on this pathway. The drug is approved in a number of countries, including the US, for RA.
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thanks for sharing. UM does some amazing work.
Drug resistance is a huge puzzle in cancer treatment for all kinds of cancers. But pieces are coming together.
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Interesting! Do you think this supports avoiding foods that promote inflammation and eating foods that are anti-inflammatory?
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You bet, sweetbean, if I may answer your question. At least according to this video, which was in an article posted by maize.
http://finance.yahoo.com/video/womans-doc-fighting-inflammation-food-191300321.html
http://finance.yahoo.com/news/science-behind-americas-deadliest-diseases-031400919.html
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I remember that there was a study on RA and BC link. AR patients had reduced BC risk, the cause was conjectured to be due to the NSAIDS AR patients take a lot.
It will be cool if NSAIDS, betablockers, RA medications like tocilizumab, metformin's effect on different subtype of BC and different mechanisms of actions are all teased out. There could be additive/subtractive/multiplicative effects, that need to figure out too. But definitive clinical trials for 3 of these 4 are going to be very hard.
I admit I'm a lurker at another MBC website. Very interesting discussions below:
http://bcmets.org/articles/152285
Paul mentions the disparity in how quickly AIDS drugs (for symptom relief and cure) goes through approval vs how slowly Cancer drugs goes through approval.
One thing I noticed is the difference in transmission mode and charity altitude that tries hard not to offend or shock.
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