Vitamin D levels at diagnosis

http://www.oncologystat.com/journals/journal_scans/Vitamin_D_Status_at_Breast_Cancer_Diagnosis_Correlation_With_Tumor_Characteristics_Disease_Outcome_and_Genetic_Determinants_of_Vitamin_D_Insufficiency.html

A large cohort study correlated vitamin D levels with tumor size and overall survival, showing improved breast-cancer specific outcomes associated with increased vitamin D levels in postmenopausal women.

Comments

  • coraleliz
    coraleliz Member Posts: 1,523
    edited July 2012

    I didn't "login" just read the summary. Here's my thoughts & i live in California & get year round sun. The dermatologist is always getting after me. The vitamin D level will have to be addressed at an early age. Since many of our tumors are years in the making. I don't really believe that one can acheive a "therapuetic" vitamin D level after 40 without suplementation. I haven't done or read of any studies, but I have many freinds & coworkers who have had there Vitamin D levels check. We were all low. I was the highest at 25. I guess I don't need to say it..........but.........I'm the one who got the cancer. I know very unscientific.......

  • Thatgirl
    Thatgirl Member Posts: 276
    edited July 2012

    Coral,

    I read the article and no where does it mention Vitamin D being a cure for BC. Because BC is 10 or more diseases, although your friends had 1 disease (low VitD) they may not have the other 9+ that started your BC. You are ER+ so you may have ED. Your friends may not be ED.

    Also, is your Derm getting after you because your skin is tanned? Being tanned does not mean Vitamin D absorption. A lot of posters here who live in AZ or CA feel as though they are getting tons of sun due to their tan but their blood work says all that tanning didnt increase Vit D levels to a therapuetic level.

    If people over 40 eat fat daily, have proper levels of K, Mag, Zinc and can lay in the sun for 30 minutes a day with 40% of their body uncovered, I believe they can make enough Vit D. Since most people can not lay in the sun in the middle of the day supplementation is required.

    This is not directed at you Coral but why is it when some articles are posted, people chime in and say "Well, I blah, blah, blah, blah and did that and still got cancer" Really? These studies are to tell us what can lower our risk not what the cure for cancer is. I think people like to say "They are wrong" so they don't feel as though they did or did not do anything to cause their cancer.

  • mary625
    mary625 Member Posts: 1,056
    edited July 2012

    Does the study state desirable levels for Vit. D?

  • coraleliz
    coraleliz Member Posts: 1,523
    edited July 2012

    Thatgirl-The reason my dermatologist lectures me is because I'm tan but also have had many precancerous, basal cell & a couple of squamous cell skin cancers. What I really believe my post is about, is that vitamin D supplementation will have to begin at rather young age because BC can take forever(many years to grow). And no I don't think I did ANYTHING to cause my cancer.

  • Thatgirl
    Thatgirl Member Posts: 276
    edited July 2012

    Coral, be careful out in the sun. Supplementation may be a better option for you. No one should  blame themselves for their cancer. Science has not found out what causes cancer, they only have risk factors.

  • camillegal
    camillegal Member Posts: 16,882
    edited July 2012

    I don't know st all--I don't think anything is wrong or anything is right. I think of my parents alone--My dad was a perfect candidate for skin or other types of cancer. he ate wrong, drank alot, stayed in the sun alot did whatever and he died at 96 quickly with no cancer ever. My Mom took care of herself ate properly excercised, took vitamins saw Drs regularly and altho she lived a long life cancer got the better of her.

    I realize tht there are studies oit for possibly aoiding cancer---but since no one really know why or how we get it how do the studies come into view.

    Cancer is a terrorist that hides for decades  or maybe not but when it attacks it can be gone but who knows if 1 cell will hide somewhere else--no one knows. Trearment has come a long way but there is no cure--maybe u'll get it once and be lucky enough that it doesn't roar it's ugly head again. And that all u can hope for and do the best u can.

  • slousha
    slousha Member Posts: 312
    edited July 2012
    Hi dear ladies,

    I'm a little longer on this therapy so some information about Vit D3. Before taking Femara I was at Endocrinologist
    to see how my bones are doing. I have had slightly osteopenia in my hips and beginning of osteoporosis on backbone.  My D3 was 37 and it was said BC ladies should have it 60-80. Last summer having a  sunny balcony, was taking sun bath every day at midday, without sun crème, only 15 minutes each site. In 9 months my levels raised from 37 to 72 without medicines.
    Now I'm still taking 1000 units per day to retain the state in months without sun.

    Sorry, English isn't my native language

    Greetings and best wishes

    Usha

  • Shayne
    Shayne Member Posts: 1,500
    edited July 2012

    My MO said living in AZ and spending time in the sun has nothing to do with Vit D levels.  Get them checked.  Ive also read that it can help with bone and joint pain while on AIs.......  Im waiting for results from my levels.

  • Husband11
    Husband11 Member Posts: 2,264
    edited July 2012

    Is the article accessable to readers without joining a forum?  If not, I'll cut and paste it here.

  • coraleliz
    coraleliz Member Posts: 1,523
    edited July 2012

    Timothy-It's not accessible unless you sign in or join.

  • Husband11
    Husband11 Member Posts: 2,264
    edited July 2012

    Vitamin D Status at Breast Cancer Diagnosis: Correlation With Tumor Characteristics, Disease Outcome and Genetic Determinants of Vitamin D Insufficiency Carcinogenesis. 2012 May 23;[Epub Ahead of Print], S Hatse, D Lambrechts, A Verstuyf, A Smeets, B Brouwers, T Vandorpe, O Brouckaert, G Peuteman, A Laenen, L Verlinden, C Kriebitzsch, AS Dieudonne, R Paridaens, P Neven, MR Christiaens, R Bouillon, H WildiersAbstract A large cohort study correlated vitamin D levels with tumor size and overall survival, showing improved breast-cancer specific outcomes associated with increased vitamin D levels in postmenopausal women.TAKE-HOME MESSAGEA large cohort study correlated vitamin D levels with tumor size and overall survival, showing improved breast-cancer specific outcomes associated with increased vitamin D levels in postmenopausal women.SUMMARYOncologySTAT Editorial TeamHatse and colleagues set out to examine the association between serum 25-hydroxyvitamin D3 (25OHD) levels, dietary vitamin D intake, and the risk of cancer. They noted that vitamin D supplementation has not yet been a standard element of cancer prevention. The controversy surrounding the effect of vitamin D supplementation on certain malignancies and whether its use should be encouraged is particularly relevant in women with breast cancer. It is known that more than 60% of cases occur in postmenopausal women, a population characterized by a high prevalence of vitamin D deficiency and osteoporosis.In this study, 1,800 patients were randomly classified into three categories according to 25OHD levels: low, intermediate, and high. Patients in the low group had 25OHD levels <20 ng/mL. The intermediate group had 25OHD levels between 20 and 30 ng/mL. The high group had levels of 25OHD >30 ng/mL. In all, 35.9% of patients were in the high group, 31.7% were in the intermediate group, and 32.4% were in the low group.The investigators utilized linear regression models to examine the association between 25OHD levels and tumor characteristics. These characteristics included tumor size, tumor grade, nodal stage, estrogen receptor levels, and HER2 status. Lymph node involvement was also analyzed. Primary outcomes were twofold: disease-specific survival (DSS) and disease-free interval (DFI). The latter was defined as the time elapsing between breast cancer diagnosis and local recurrence and/or lymph node metastasis and/or distant metastasis. Regarding overall survival, significant effects were observed for age, tumor size, lymph node involvement, tumor grade, and estrogen-receptor status.In terms of DSS, the investigators found a significant inverse correlation between serum 25OHD levels and the risk of breast cancer-related mortality. High 25OHD levels were associated with improved DSS in postmenopausal women (hazard ratio [HR], 0.15 for 25OHD > 30 ng/mL vs ≤30 ng/mL; 95% CI, 0.03-0.63; P = .0097), compared with premenopausal women (HR, 0.93; 95% CI, 0.43-2.02; P = .8527). In addition, favorable vitamin D status appeared to be linked to improved outcomes in postmenopausal women.It was suggested by the investigators that this vitamin D benefit in postmenopausal women may be due to the favorable effect of vitamin D on bone density and metabolism and the low estrogen environment in bone. In premenopausal women, higher levels of estrogen may negate the bone-protecting benefits of vitamin D supplementation.In closing, this study demonstrated that reduced 25OHD levels were associated with increased tumor size in women with breast cancer and improved outcome in postmenopausal women. Vitamin D could be involved in local growth-inhibitory effects on breast tumors. However, further studies are warranted to clarify the role of vitamin D supplementation as a cancer preventive or inhibitory therapy.

  • luv_gardening
    luv_gardening Member Posts: 1,393
    edited July 2012

    That girl, You said..

    Because BC is 10 or more diseases, although your friends had 1 disease (low VitD) they may not have the other 9+ that started your BC. 

    I'm not sure if you were thinking of the ten or more BC types recently discovered.  They are nothing to do with the causes or risk factors leading to BC.  They describe the genetic type of a tumour, such as whether it's Luminal A, Luminal B, Basal-like, Her2+ or some mixture of those.

    Let me know if I've misunderstood what you mean. If you mean we need more than one risk factor to trigger BC, yes, that's possible though some of us have very few risk factors so there must be more we don't know about yet.  I hope more can be identified to help women avoid this cancer.

  • Shayne
    Shayne Member Posts: 1,500
    edited July 2012

    Just got my results - 22.  Going to get Vit D3 tomorrow - My Onc recommended 3,000 units......

  • Thatgirl
    Thatgirl Member Posts: 276
    edited July 2012

    Joy,

    I think we are talking about two different things.

  • camillegal
    camillegal Member Posts: 16,882
    edited July 2012

    I take 1 capsule a week 50,000 units==She wrote a persciption--It's so silly cuz it's once a week and I have to write what day it is or I'll forget.--I didn't even ask my numbers--I never think of those things--I'm going to be going every week for a workup for blood cuz my numbers vary to to much-so this way they can watch them so I won't keep on ending up in the hospital for days. Since i moved I have all new Drs. so it's my fault I didn't start cuz I know I have big blood count probs. And I put it off so I have to catch up--I'm still low on others but not critical so I can just take more pills for now.--This goes on and on and it's aggrevating when people tell me what I'm doing wrong cuz I should feel fine now--Sorry for my rant. )Not my close friends and family at least)

  • MILCHICK
    MILCHICK Member Posts: 112
    edited August 2012

    Just wondering if anyone here had low Vitamin D and/or B12 prior to or at diagnosis? If so, would you mind sharing info on your levels as well as stage/grade/type BC, etc. Any info would be appreciated.



    Me:

    Low B12 level = 18, noted in Feb 2010

    1st Suspicious Mammo in April 2010

    Low Vitamin D in Dec 2010 (was not given the exact count/level)

    2nd Suspicious Mammo & US in August 2011 (put on 6 month watch & wait)

    3rd Suspicious Mammo & US in Feb 2012 (some growth but still told watch & wait)

    Pain in breast w/other symptoms in May 2012

    Lump & pain in armpit & pain in breast June 2012

    Add swollen Lymph node behind ear .5-1cm July 2012 (along with a whole slew of other symptoms that may not be related)

    Mammo/US finally scheduled for 10 Aug 2012



    Any thoughts??????

  • MILCHICK
    MILCHICK Member Posts: 112
    edited August 2012

    Just "bumping" this up and praying that everyone will chime in pretty soon.



    God bless you all.

  • momof3boys
    momof3boys Member Posts: 896
    edited August 2012

    My Vit D level was 30 at diagnosis. You can see my stats below....

  • dipad
    dipad Member Posts: 174
    edited August 2012

    I never had my vitD checked prior to bc. When diagnosed I was at 29. I dropped during the next two months down to 12. Onc put me on 50,000 units of vit D per week for 6 weeks, I am now back to 29. 

  • MILCHICK
    MILCHICK Member Posts: 112
    edited August 2012

    Thank you ladies! I appreciate your input. I'm going to have to get my info from the doctor who did it. I'm super curious now. I hope to know more about my problem on Friday or at least some time next week.

    God bless you all.

    I will include you both in my prayers.

    Thank you again.

  • nancyjac
    nancyjac Member Posts: 120
    edited August 2012

    I'm getting into this whole vitamin D thing very late and boy, it sure is confusing.  Conflicting info everywhere.  I just had my vitamin D levels tested, to my knowledge, for the first time.  Result was 26 with normal range being 30-100 (according to the lab).  My MO is looking to reach an initial target of at least 40. Because I already had osteopenia before cancer DX, MO had me bump up my calcium supplementation which includes Vit D, so prior to testing, I was taking 3000 IU with my calcium supplement, plus another 800 IU with my multivitamin.  She now wants me to add another 1000 IU of Vit. D, making a daily total of 4800 IU.  She told me that bringing up Vit D levels is hard, particularly post menopausal and that it will probably take several months just to get it up to 40. 

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