Vitamin D levels at diagnosis
A large cohort study correlated vitamin D levels with tumor size and overall survival, showing improved breast-cancer specific outcomes associated with increased vitamin D levels in postmenopausal women.
Comments
-
I didn't "login" just read the summary. Here's my thoughts & i live in California & get year round sun. The dermatologist is always getting after me. The vitamin D level will have to be addressed at an early age. Since many of our tumors are years in the making. I don't really believe that one can acheive a "therapuetic" vitamin D level after 40 without suplementation. I haven't done or read of any studies, but I have many freinds & coworkers who have had there Vitamin D levels check. We were all low. I was the highest at 25. I guess I don't need to say it..........but.........I'm the one who got the cancer. I know very unscientific.......
-
Coral,
I read the article and no where does it mention Vitamin D being a cure for BC. Because BC is 10 or more diseases, although your friends had 1 disease (low VitD) they may not have the other 9+ that started your BC. You are ER+ so you may have ED. Your friends may not be ED.
Also, is your Derm getting after you because your skin is tanned? Being tanned does not mean Vitamin D absorption. A lot of posters here who live in AZ or CA feel as though they are getting tons of sun due to their tan but their blood work says all that tanning didnt increase Vit D levels to a therapuetic level.
If people over 40 eat fat daily, have proper levels of K, Mag, Zinc and can lay in the sun for 30 minutes a day with 40% of their body uncovered, I believe they can make enough Vit D. Since most people can not lay in the sun in the middle of the day supplementation is required.
This is not directed at you Coral but why is it when some articles are posted, people chime in and say "Well, I blah, blah, blah, blah and did that and still got cancer" Really? These studies are to tell us what can lower our risk not what the cure for cancer is. I think people like to say "They are wrong" so they don't feel as though they did or did not do anything to cause their cancer.
-
Does the study state desirable levels for Vit. D?
-
Thatgirl-The reason my dermatologist lectures me is because I'm tan but also have had many precancerous, basal cell & a couple of squamous cell skin cancers. What I really believe my post is about, is that vitamin D supplementation will have to begin at rather young age because BC can take forever(many years to grow). And no I don't think I did ANYTHING to cause my cancer.
-
Coral, be careful out in the sun. Supplementation may be a better option for you. No one should blame themselves for their cancer. Science has not found out what causes cancer, they only have risk factors.
-
I don't know st all--I don't think anything is wrong or anything is right. I think of my parents alone--My dad was a perfect candidate for skin or other types of cancer. he ate wrong, drank alot, stayed in the sun alot did whatever and he died at 96 quickly with no cancer ever. My Mom took care of herself ate properly excercised, took vitamins saw Drs regularly and altho she lived a long life cancer got the better of her.
I realize tht there are studies oit for possibly aoiding cancer---but since no one really know why or how we get it how do the studies come into view.
Cancer is a terrorist that hides for decades or maybe not but when it attacks it can be gone but who knows if 1 cell will hide somewhere else--no one knows. Trearment has come a long way but there is no cure--maybe u'll get it once and be lucky enough that it doesn't roar it's ugly head again. And that all u can hope for and do the best u can.
-
Hi dear ladies,
I'm a little longer on this therapy so some information about Vit D3. Before taking Femara I was at Endocrinologist
to see how my bones are doing. I have had slightly osteopenia in my hips and beginning of osteoporosis on backbone. My D3 was 37 and it was said BC ladies should have it 60-80. Last summer having a sunny balcony, was taking sun bath every day at midday, without sun crème, only 15 minutes each site. In 9 months my levels raised from 37 to 72 without medicines.
Now I'm still taking 1000 units per day to retain the state in months without sun.Sorry, English isn't my native language
Greetings and best wishes
Usha
-
My MO said living in AZ and spending time in the sun has nothing to do with Vit D levels. Get them checked. Ive also read that it can help with bone and joint pain while on AIs....... Im waiting for results from my levels.
-
Is the article accessable to readers without joining a forum? If not, I'll cut and paste it here.
-
Timothy-It's not accessible unless you sign in or join.
-
Vitamin D Status at Breast Cancer Diagnosis: Correlation With Tumor Characteristics, Disease Outcome and Genetic Determinants of Vitamin D Insufficiency Carcinogenesis. 2012 May 23;[Epub Ahead of Print], S Hatse, D Lambrechts, A Verstuyf, A Smeets, B Brouwers, T Vandorpe, O Brouckaert, G Peuteman, A Laenen, L Verlinden, C Kriebitzsch, AS Dieudonne, R Paridaens, P Neven, MR Christiaens, R Bouillon, H WildiersAbstract A large cohort study correlated vitamin D levels with tumor size and overall survival, showing improved breast-cancer specific outcomes associated with increased vitamin D levels in postmenopausal women.TAKE-HOME MESSAGEA large cohort study correlated vitamin D levels with tumor size and overall survival, showing improved breast-cancer specific outcomes associated with increased vitamin D levels in postmenopausal women.SUMMARYOncologySTAT Editorial TeamHatse and colleagues set out to examine the association between serum 25-hydroxyvitamin D3 (25OHD) levels, dietary vitamin D intake, and the risk of cancer. They noted that vitamin D supplementation has not yet been a standard element of cancer prevention. The controversy surrounding the effect of vitamin D supplementation on certain malignancies and whether its use should be encouraged is particularly relevant in women with breast cancer. It is known that more than 60% of cases occur in postmenopausal women, a population characterized by a high prevalence of vitamin D deficiency and osteoporosis.In this study, 1,800 patients were randomly classified into three categories according to 25OHD levels: low, intermediate, and high. Patients in the low group had 25OHD levels <20 ng/mL. The intermediate group had 25OHD levels between 20 and 30 ng/mL. The high group had levels of 25OHD >30 ng/mL. In all, 35.9% of patients were in the high group, 31.7% were in the intermediate group, and 32.4% were in the low group.The investigators utilized linear regression models to examine the association between 25OHD levels and tumor characteristics. These characteristics included tumor size, tumor grade, nodal stage, estrogen receptor levels, and HER2 status. Lymph node involvement was also analyzed. Primary outcomes were twofold: disease-specific survival (DSS) and disease-free interval (DFI). The latter was defined as the time elapsing between breast cancer diagnosis and local recurrence and/or lymph node metastasis and/or distant metastasis. Regarding overall survival, significant effects were observed for age, tumor size, lymph node involvement, tumor grade, and estrogen-receptor status.In terms of DSS, the investigators found a significant inverse correlation between serum 25OHD levels and the risk of breast cancer-related mortality. High 25OHD levels were associated with improved DSS in postmenopausal women (hazard ratio [HR], 0.15 for 25OHD > 30 ng/mL vs ≤30 ng/mL; 95% CI, 0.03-0.63; P = .0097), compared with premenopausal women (HR, 0.93; 95% CI, 0.43-2.02; P = .8527). In addition, favorable vitamin D status appeared to be linked to improved outcomes in postmenopausal women.It was suggested by the investigators that this vitamin D benefit in postmenopausal women may be due to the favorable effect of vitamin D on bone density and metabolism and the low estrogen environment in bone. In premenopausal women, higher levels of estrogen may negate the bone-protecting benefits of vitamin D supplementation.In closing, this study demonstrated that reduced 25OHD levels were associated with increased tumor size in women with breast cancer and improved outcome in postmenopausal women. Vitamin D could be involved in local growth-inhibitory effects on breast tumors. However, further studies are warranted to clarify the role of vitamin D supplementation as a cancer preventive or inhibitory therapy.
-
That girl, You said..
Because BC is 10 or more diseases, although your friends had 1 disease (low VitD) they may not have the other 9+ that started your BC.
I'm not sure if you were thinking of the ten or more BC types recently discovered. They are nothing to do with the causes or risk factors leading to BC. They describe the genetic type of a tumour, such as whether it's Luminal A, Luminal B, Basal-like, Her2+ or some mixture of those.
Let me know if I've misunderstood what you mean. If you mean we need more than one risk factor to trigger BC, yes, that's possible though some of us have very few risk factors so there must be more we don't know about yet. I hope more can be identified to help women avoid this cancer.
-
Just got my results - 22. Going to get Vit D3 tomorrow - My Onc recommended 3,000 units......
-
Joy,
I think we are talking about two different things.
-
I take 1 capsule a week 50,000 units==She wrote a persciption--It's so silly cuz it's once a week and I have to write what day it is or I'll forget.--I didn't even ask my numbers--I never think of those things--I'm going to be going every week for a workup for blood cuz my numbers vary to to much-so this way they can watch them so I won't keep on ending up in the hospital for days. Since i moved I have all new Drs. so it's my fault I didn't start cuz I know I have big blood count probs. And I put it off so I have to catch up--I'm still low on others but not critical so I can just take more pills for now.--This goes on and on and it's aggrevating when people tell me what I'm doing wrong cuz I should feel fine now--Sorry for my rant. )Not my close friends and family at least)
-
Just wondering if anyone here had low Vitamin D and/or B12 prior to or at diagnosis? If so, would you mind sharing info on your levels as well as stage/grade/type BC, etc. Any info would be appreciated.
Me:
Low B12 level = 18, noted in Feb 2010
1st Suspicious Mammo in April 2010
Low Vitamin D in Dec 2010 (was not given the exact count/level)
2nd Suspicious Mammo & US in August 2011 (put on 6 month watch & wait)
3rd Suspicious Mammo & US in Feb 2012 (some growth but still told watch & wait)
Pain in breast w/other symptoms in May 2012
Lump & pain in armpit & pain in breast June 2012
Add swollen Lymph node behind ear .5-1cm July 2012 (along with a whole slew of other symptoms that may not be related)
Mammo/US finally scheduled for 10 Aug 2012
Any thoughts?????? -
Just "bumping" this up and praying that everyone will chime in pretty soon.
God bless you all. -
My Vit D level was 30 at diagnosis. You can see my stats below....
-
I never had my vitD checked prior to bc. When diagnosed I was at 29. I dropped during the next two months down to 12. Onc put me on 50,000 units of vit D per week for 6 weeks, I am now back to 29.
-
Thank you ladies! I appreciate your input. I'm going to have to get my info from the doctor who did it. I'm super curious now. I hope to know more about my problem on Friday or at least some time next week.
God bless you all.
I will include you both in my prayers.
Thank you again. -
I'm getting into this whole vitamin D thing very late and boy, it sure is confusing. Conflicting info everywhere. I just had my vitamin D levels tested, to my knowledge, for the first time. Result was 26 with normal range being 30-100 (according to the lab). My MO is looking to reach an initial target of at least 40. Because I already had osteopenia before cancer DX, MO had me bump up my calcium supplementation which includes Vit D, so prior to testing, I was taking 3000 IU with my calcium supplement, plus another 800 IU with my multivitamin. She now wants me to add another 1000 IU of Vit. D, making a daily total of 4800 IU. She told me that bringing up Vit D levels is hard, particularly post menopausal and that it will probably take several months just to get it up to 40.
Categories
- All Categories
- 679 Advocacy and Fund-Raising
- 289 Advocacy
- 68 I've Donated to Breastcancer.org in honor of....
- Test
- 322 Walks, Runs and Fundraising Events for Breastcancer.org
- 5.6K Community Connections
- 282 Middle Age 40-60(ish) Years Old With Breast Cancer
- 53 Australians and New Zealanders Affected by Breast Cancer
- 208 Black Women or Men With Breast Cancer
- 684 Canadians Affected by Breast Cancer
- 1.5K Caring for Someone with Breast cancer
- 455 Caring for Someone with Stage IV or Mets
- 260 High Risk of Recurrence or Second Breast Cancer
- 22 International, Non-English Speakers With Breast Cancer
- 16 Latinas/Hispanics With Breast Cancer
- 189 LGBTQA+ With Breast Cancer
- 152 May Their Memory Live On
- 85 Member Matchup & Virtual Support Meetups
- 375 Members by Location
- 291 Older Than 60 Years Old With Breast Cancer
- 177 Singles With Breast Cancer
- 869 Young With Breast Cancer
- 50.4K Connecting With Others Who Have a Similar Diagnosis
- 204 Breast Cancer with Another Diagnosis or Comorbidity
- 4K DCIS (Ductal Carcinoma In Situ)
- 79 DCIS plus HER2-positive Microinvasion
- 529 Genetic Testing
- 2.2K HER2+ (Positive) Breast Cancer
- 1.5K IBC (Inflammatory Breast Cancer)
- 3.4K IDC (Invasive Ductal Carcinoma)
- 1.5K ILC (Invasive Lobular Carcinoma)
- 999 Just Diagnosed With a Recurrence or Metastasis
- 652 LCIS (Lobular Carcinoma In Situ)
- 193 Less Common Types of Breast Cancer
- 252 Male Breast Cancer
- 86 Mixed Type Breast Cancer
- 3.1K Not Diagnosed With a Recurrence or Metastases but Concerned
- 189 Palliative Therapy/Hospice Care
- 488 Second or Third Breast Cancer
- 1.2K Stage I Breast Cancer
- 313 Stage II Breast Cancer
- 3.8K Stage III Breast Cancer
- 2.5K Triple-Negative Breast Cancer
- 13.1K Day-to-Day Matters
- 132 All things COVID-19 or coronavirus
- 87 BCO Free-Cycle: Give or Trade Items Related to Breast Cancer
- 5.9K Clinical Trials, Research News, Podcasts, and Study Results
- 86 Coping with Holidays, Special Days and Anniversaries
- 828 Employment, Insurance, and Other Financial Issues
- 101 Family and Family Planning Matters
- Family Issues for Those Who Have Breast Cancer
- 26 Furry friends
- 1.8K Humor and Games
- 1.6K Mental Health: Because Cancer Doesn't Just Affect Your Breasts
- 706 Recipe Swap for Healthy Living
- 704 Recommend Your Resources
- 171 Sex & Relationship Matters
- 9 The Political Corner
- 874 Working on Your Fitness
- 4.5K Moving On & Finding Inspiration After Breast Cancer
- 394 Bonded by Breast Cancer
- 3.1K Life After Breast Cancer
- 806 Prayers and Spiritual Support
- 285 Who or What Inspires You?
- 28.7K Not Diagnosed But Concerned
- 1K Benign Breast Conditions
- 2.3K High Risk for Breast Cancer
- 18K Not Diagnosed But Worried
- 7.4K Waiting for Test Results
- 603 Site News and Announcements
- 560 Comments, Suggestions, Feature Requests
- 39 Mod Announcements, Breastcancer.org News, Blog Entries, Podcasts
- 4 Survey, Interview and Participant Requests: Need your Help!
- 61.9K Tests, Treatments & Side Effects
- 586 Alternative Medicine
- 255 Bone Health and Bone Loss
- 11.4K Breast Reconstruction
- 7.9K Chemotherapy - Before, During, and After
- 2.7K Complementary and Holistic Medicine and Treatment
- 775 Diagnosed and Waiting for Test Results
- 7.8K Hormonal Therapy - Before, During, and After
- 50 Immunotherapy - Before, During, and After
- 7.4K Just Diagnosed
- 1.4K Living Without Reconstruction After a Mastectomy
- 5.2K Lymphedema
- 3.6K Managing Side Effects of Breast Cancer and Its Treatment
- 591 Pain
- 3.9K Radiation Therapy - Before, During, and After
- 8.4K Surgery - Before, During, and After
- 109 Welcome to Breastcancer.org
- 98 Acknowledging and honoring our Community
- 11 Info & Resources for New Patients & Members From the Team