taxotere side effects

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  • ljhm
    ljhm Member Posts: 60
    edited July 2012

    Had treatment on Wednesday and my mouth is so full of sores I can't eat. Thrush on top of that.  Have mouthwash and nystatin, guess I just have to wait for the dexamethosone to wear off.  Making smoothies out of ensure, at least it tastes good, love the butter pecan.  Wallowing toay.  Guess it's a percocet and reading day.  Just needed to vent.

  • Melrosemelrose
    Melrosemelrose Member Posts: 3,018
    edited July 2012
    lijhm- OMG!!!  Hope you feel better very very soon!!!  Sorry to hear about the thrush and mouth sores.  I've had the mouth sores which seem to do better after daily multiple mouth rinsings with baking soda/salt/warm water.  The formula I use for each mouth rinsing is 1/4 teaspoon baking soda + 1/4 teaspoon salt + 1 cup warm water.  The taste of blah but I do notice improvement within a few days.  Always okay to whine, rant and vent!!!!Wink
  • ljhm
    ljhm Member Posts: 60
    edited July 2012

    Melrosemeir

    I do use your formula for the sores and it does help, just not fast enough.  Have my mouth full of ice chips, seems to help.  This is the nastiest drug but I will just count the days.  Last session I had 10 days of side effects so hopefully this time it will be less.  It's great to have a place to vent where people understand what you're going through :)

  • Alicethecat
    Alicethecat Member Posts: 535
    edited July 2012

    Hello ladies

    My oncologist reduced the dose of my Taxotere after round 1 of the infusion and the effects have been miraculous.

    Feeling so well. No bone aches in spine, no temperature of 38 degrees, no feeling as if all the stuffing has been knocked out of me.

    Even went for a walk today into town for coffee.

    Totally amazing. Terrific Taxotere - at the right dose.

    Have courage ladies! Once the dose is right for you, you could get a nice surprise!

    Best wishes

     Alice

  • Melrosemelrose
    Melrosemelrose Member Posts: 3,018
    edited July 2012
    lijhm- Just wondering if you are eating/sucking on ice during your Taxotere infusion?  That may help.  Thank goodness you are to get some relief with ice and shakes.  Feel better soon!!!  I just hate it when my mouth is funky after my treatments.
  • ljhm
    ljhm Member Posts: 60
    edited July 2012

    Yup, I have a smoothie and ice chips during treatment.  Starting to feel better tonight  When the ulcers go away I can use vinegar & water to get rid of the yeast, works much faster than nystatin.  Hopefully will be better tomorrow, this better be worth it!

  • kltb04
    kltb04 Member Posts: 1,051
    edited July 2012

    Hello all. Posting from my phone so I may miss some things.



    Tazzy - how's the tingling? Improving I hope.



    Ljhm - oh my you have had a perfectly awful time of it. I tend to agree that a dosage reduction may be in order. They have a bit of leeway to go up or down without compromising your treatment.



    Alice - glad that this round is going much better for you.



    As for me I had one day where I just slept after the Nuelasta but for the most part TX #2 has been easy. I am tired and I don't do much of anything but nothing severe.

  • Tazzy
    Tazzy Member Posts: 2,546
    edited July 2012

    Lijhm -  you poor thing.   I did the same mouthwash as Melrose and it worked for me too.   I did use it daily and after every time after I ate (where possible).    And yes it is great to vent with people who understand and don't mind in the least how much any of us vent.  Just get it out of your system.  Here's to tomorrow being a better day. (Oh! just read you do use that - if you dont, try using it daily - even if your mouth sores clear up).

    Kltb - thanks, yes the tingling really has improved.   Just slightly in my left 3 middle toes - weird.  What has really pissed me off is even with the wearing of frozen gloves during treatment my nails are so very weak.  Even if I say so myself  I always had such lovely strong long nails but I have had to cut them down so they don't break or I don't catch them on something and make them ‘ping' off.  Still like everything with this, everything grows back and eventually hair and nails are restored.

    I hope everyone is is doing relatively well.

  • lisa2012
    lisa2012 Member Posts: 652
    edited July 2012

    Hey Tazzy, hope you had fun camping (right? not mixed up, am I?) I think of you as tax-o-tears run down my face. Fortunately at our party yesterday I had a dry spell for most of the time.

  • Tazzy
    Tazzy Member Posts: 2,546
    edited July 2012
    Hi Lisa - yes its me Smile  Darn bloody tax-o-tears eh?  But that's great you had a dry spell yesterday for your party.   Yep camping was a blast and the tax-o-tears weren't to bad for me either - which surprised me.  I even took a new box of tissues expecting the worst.
  • ljhm
    ljhm Member Posts: 60
    edited July 2012

    Day five after treatment and its the worst one yet.  Achy,mouth still bad and thrush still present.  Nystatin only works for so long.  Am going to ask for a dosage adjustment next time.  Thank god for pain killers, didn't need any yesterday but one so far today.  If last time is any indication I have 5 days of SE's to go   argghhhhhhhhhhhh.

  • Melrosemelrose
    Melrosemelrose Member Posts: 3,018
    edited July 2012
    ljhm- No fair, no fair, no fair..... not fair that you are still suffering with thrush!!!! So sorry you are having a rough time with the side effects.  Hope you feel better soon!!!!!
  • Tazzy
    Tazzy Member Posts: 2,546
    edited July 2012

    ljhm.... so sorry you are still suffering so badly - you're right Melrose... its not fair, not fair at all.   Hang in there honey, take your painkillers and rest up.  

    Hope everyone is managing to smile, enjoy their day and be relatively SE free.

  • ljhm
    ljhm Member Posts: 60
    edited July 2012

    I still have thrush because I am also on prednisone regularly, so when the dexamethosone started it kick started it.  You're right no fair.  I do feel better after a pain med so maybe I can nap this afternoon.  Thanks everybody.

  • kltb04
    kltb04 Member Posts: 1,051
    edited July 2012

    Tazzy - that's one thing I never had - long nice nails - or great hair for that matter.  Not that I want them to come off or lift, lol, nor did I want to be bald but in the scheme of things, no great loss. ;)

    ljhm - UGH!  You just cannot catch a break!  Feel better.

    Well, my white count was up so I guess I can thank Nuelasta - it was 14.7!  It was never that high on A/C...I am still "slightly anemic" as usual.  But at least - had I somewhere to go or something to do - I would feel like I could be off house arrest. :)

  • SpecialK
    SpecialK Member Posts: 16,486
    edited July 2012

    ljhm - ask your MO about a medication called Caphosol.  It is two ampules that you mix together right before you swish and spit - worked great for my mouth sores.  I only had them after tx#1, after which I consumed to much acidic drink/food.  I curbed that with subsequent tx and did not have mouth sores again - but the Caphosol got rid of at least a dozen sores in 48 hours.

  • ljhm
    ljhm Member Posts: 60
    edited July 2012

    Will definitely ask for that, thanks for the tip.

  • Hikergal
    Hikergal Member Posts: 74
    edited July 2012

    Hi all,

    Ended up taking my plane trip to Michigan and so glad I did, it was a great distraction!  Was really careful with handwashing.  Felt fatigued for a few days and began "my good week" starting 7/4ish.  Had a really bad zit breakout followed by of all things my 2 week late period. Was really surprised to get that! 

    Hair began shedding dramatically on day 14, right on target from what I hear  and began to fall out by the handfuls on day 16.  Had it buzzed off that day. Cried during the buzz cut but am over it now.  The wig is hard to get used (scratchy) and I find wearing a ball cap to the store etc is actually comfy etc in this summer heat.  It was so weird to anticipate the hair loss and wondering if I should have just buzzed if off sooner.  Wanted to remain looking as normal as possible though since I was visiting friends and relatives.

    Go for 2nd treatment tomorrow.  I am not as anxious as I was for the first one probably now that I know what to expect.  I have stocked up on potatoes and pasta for comfort foods right after treatment. 

    Hope everyone else is doing ok!

  • Melrosemelrose
    Melrosemelrose Member Posts: 3,018
    edited July 2012
    Hikergal- Good luck tomorrow with your 2nd round!!!  I saw you asked the question about when the brows and lashes go on the Hair thread.  Sometimes, you don't lose those until after you finish with chemo when you are on the Cytoxan/Taxotere regimen.  I'm heading into round #5 next Tuesday and notice I have thinning of my eyebrows and have lost a few lower eyelashes.  I have some hair stubs trying to grow which is reassuring that my hair follicles are trying really hard to come back.
  • Tazzy
    Tazzy Member Posts: 2,546
    edited July 2012

    Good luck tomorrow hikergal.   My comfort foods were mashed potatoes and brussel sprouts with gravy Smile

    My hair is now growing back (on my head) 18 days PFC.   If only my eyebrows and lashes were coming back as thick.  I am happy not to have my leg and armpit hair return yet.   Yay melrose for hard working follicles.

  • lisa2012
    lisa2012 Member Posts: 652
    edited July 2012

    Why in God's name would brows and lashes go weeks after chemo us done?? I've noticed a bit of eyelash thinning, eyebrows still OK. Eyes still you-know-what ting, nails hurting less but one is looking like its kind of lifting. 3weeks PFC tomorrow! My PT said that if I havent gotten neuropathy yet most likely I won't get it, hurray.

    How long does it take for the steroid water weight to go? Does it go by itself or do I have to do something?

  • dgcote
    dgcote Member Posts: 28
    edited July 2012

    Just started chemo, but the meds are the worst side effect I have been having. Did not take the nausia  meds today and felt much better. Still feel like i was kicked in the stomach but not like yesterday.

  • SpecialK
    SpecialK Member Posts: 16,486
    edited July 2012

    lisa - sometimes the fluid retention ends by itself - sometimes not!  You should see a change at about 6 weeks PFC - if it doesn't start to go by then you may want to ask for a mild diuretic if it is really bothering you.  Be careful about salt intake and if you feel up to exercise that makes you perspire that can be helpful, just don't overdo it!  Also - important to note that lash and brows sometimes cycle and fall out a second time.  I had thinning of brows but never completely lost them, lost all lower lashes but only one time, never lost all the top ones.  Had to shave my legs all through chemo - not fair!

    Yay for potatoes!  My food of choice during chemo - and still are!!!

  • ljhm
    ljhm Member Posts: 60
    edited July 2012

    Asked my onc nurse about Caphosol and she said " we don't use that"  so I've gone around them to my GP.  She shouldn't be making that decision anyway without asking the doctor, bitch.  Day 7 after treatment and I STILL have mouth sores but am starting to rally a bit.  Not all my hair has fallen out but rather I look like a little old man with a comb back lol.  Eyebrows and lashes till okay (knock wood).  Was at ER yesterday because of breathing problems, they did blood and my white count was still 5.8 so the wheat grass juice must be working.  Will post WBC next time I have blood taken.  You can get wheat grass juice at health food stores, costs about $15 a week for 1 oz a day.  It's supposed to cleanse your liver and build your cells.  My liver enzymes are also down so.....  Like I said before I am not a big fan of herbal meds but this one can't hurt and seems to be helping.  Looking forward to day 10 when all SE's should be gone.  My side effects don't really start until the 3rd day after treatment, is that the same for everyone? 

    Laurie

  • Hikergal
    Hikergal Member Posts: 74
    edited July 2012

    Melrosemelrose, thx for the info about brows and lashes.  Weird that they take so long to go compared with the hair. 

    dcgote, I took ginger caps in lieu of the anti nausea meds and it worked great!  After they loaded me up with all the steroids, etc I thought I would try the caps instead.  I also sipped on some gingerale.  

    Noticed some yellowing of my fingernails today but no lifting or numbness yet.  I am going to ice fingers and toes again and hope for the best.

    Thanks for the encouragement ladies for my round 2.  We just start to feel better and  have to do it again.  I am thankful though that I have the 2 weeks inbetween.

  • kltb04
    kltb04 Member Posts: 1,051
    edited July 2012

    It is just wild how the chemos work - I had shaved my head on A/C so I don't know how long it would have taken my head hair to fall out but it is already growing back - just a soft fuzz on the middle and back with still bald strips down the sides.  After my second taxotere last week, my brows are going now - fast!  I have never ever done any kind of brow makeup before so I am clueless as to how to fill them in/draw them in.  I know there are kits out there that have stencils and such.  My lashes are very sparse.  I really would like to get some fake ones for special occasions - I know they aren't recommended for everyday use but just every once in a while couldn't hurt, right?  I NEED lashes - my eye makeup is my thing...I never used to go anywhere without mascara.  I look like an alien or vampire or something. :)

    I am not having any nausea at all but I am Taxotere only - I had the Cytoxan with Adriamyacin so I had my nausea days on that combo.  The only gastro issues I have is some heartburn, not really heartburn, more of a "lump in the throat" type reflux feeling.  I have some prilosec here but I forget to take it.  

    Still no nail issues or neuropathy (knock wood).  Just exhausted and almost kind of sore feeling but that is probably from sitting around so much.  Some tearing of the eyes mainly in the mornings and runny nose.  All in all, I feel fortunate to have so few SE.

  • Melrosemelrose
    Melrosemelrose Member Posts: 3,018
    edited July 2012
    ktb04- You might head over to Ulta and get an eyebrow stencil kit.  I've been told they have them there and you may be able to get some help with learning how to pencil in the brows.    I've never been a make up gal so all is this is new to me.  I asked my onco for a prescription for Latisse which I haven't filled yet.  I have two more rounds of chemo and waiting to see what I have left after the last chemo.   I have those "Taxotears" and a little eyelid twitching. 
  • kltb04
    kltb04 Member Posts: 1,051
    edited July 2012

    Had to google Ulta - no stores here except up in the NW corner of the state but I notice they have a website, may check there.  Thanks!

  • luvBngGma
    luvBngGma Member Posts: 73
    edited July 2012
    Hello, ladies. So thankful for all the wonderful ladies who share on all the threads on the BCO website. I will be having my first Taxotere on 7/17. My MO suggested that some who suffer many SEs from FEC, may not have as many on Taxotere.  Anyone else do FEC first?  I had about 10 days on anti nausea meds on the FEC, before I could function normally. So I am hoping she was right. WinkI also asked about icing, and she was not confident that it would have much effect. Any suggestions for me prior to first treatment are welcomed. I, too, shaved my head after the first clumps starting coming out (about 16 days post first tx). not sure it would have ever all come out. Now have a few wispy hairs about 1/4" long, among the abundant stubble. Find myself rubbing my head all the time. Wink  eyebrows and lashes are still intact from the FEC.  sounds like I can expect hair loss on my head again, and on brows & lashes.
  • kltb04
    kltb04 Member Posts: 1,051
    edited July 2012

    luv - I didn't have FEC but I had A/C which was a b***h as far as nausea and stomach issues.  Had to take the antinauseas for about a week.  No nausea whatsoever on the Tax only...still get an antinausea in premeds on TX day but nothing after.  Haven't lost any more head hair since then either, only brows and lashes.  My head hair is still growing.  I am not icing, partly because no one does at my center, partly because I am lazy ;)

     The main thing I hate about the actual treatment is the addition of benadryl as a premed to prevent allergic reactions with the Tax.  It makes me sooo tired so quick and I find it impossible to sleep there during TX.

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