HIV drug for Triple Negative?

jenrio
jenrio Member Posts: 558
edited June 2014 in Clinical Trials, Research News, Podcasts, and Study Results

Currently it's in mouse only.   But we need to find the bull's eye on triple negative cancer cells, so that new drugs can target these basal (=TN) beasties.

http://www.sciencedaily.com/releases/2012/06/120606155712.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed:+sciencedaily/top_news/top_health+(ScienceDaily:+Top+News+--+Top+Health)

Since these drugs are already available for HIV patients, they may get to human clinical trials  sooner and the whole process can be easier.    

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  • Tazzy
    Tazzy Member Posts: 2,546
    edited June 2012

    Thanks for posting jenrio..makes me wish I had taken more note of science at school Smile really dont understand most of it, but as a TN I am happy to see anything which may help our cause.   Have you posted under the Triple Negative Forum at all... sure they'd be happy to see it.

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  • jenrio
    jenrio Member Posts: 558
    edited June 2012

    Another interesting article on AIDS and Breast cancer risk

    "Neoplastic breast cells commonly express CXCR4 but not CCR5. In vitro, binding HIV envelope protein to CXCR4 has been shown to induce apoptosis of neoplastic breast cells. Based on these observations, we hypothesized that breast cancer risk would be lower among women with CXCR4-tropic HIV infection"

    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014349

    It appears very few patients have both AIDS and breast cancer, yet, for some reason.

    http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400016&lng=en&nrm=iso&tlng=en

    The impact of HAART on the HIV epidemic includes greater life expectancy, a decreased risk of AIDS-defining cancers, and an increased risk of some non-AIDS-defining cancers.3,21,22 Breast cancer incidence has not been shown to be higher among HIV-infected individuals.21,22 Among women, a pattern of decreasing risk of breast cancer has been shown with increasing time since AIDS diagnosis.23 Among men and women, a statistically significant decrease in the incidence of breast cancer has been observed following the AIDS epidemic in Tanzania.24 In France, the incidence of breast cancer was significantly lower in HIV-infected women than in the French general population7,8 This apparent deficit in breast cancer cases may be explained by underreporting or competing mortality. In the United States, the deficit of breast cancer cases among women followed in the Women's Interagency HIV Study is explained by an overall lower frequency of established risk factors.25,26 

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