Women with lobular ca have more paternal than maternal links.
Breast cancer patients with lobular cancer more commonly have a father than a mother diagnosed with cancer.
Abstract
BACKGROUND:
The association between lobular breast cancer and family history is not clear. The aim of the study was to possibly identifying new hereditary patterns predisposing for cancer in the different histopathologic subtypes of breast cancer, with focus on patients with lobular breast cancer and cancer in their first degree relatives.
METHODS:
In 1676 consecutive breast cancer patients detailed family history of cancer was related to histopathologic subtype of breast cancer.
RESULTS:
Patients with lobular breast cancer were found to be significantly positively associated with having a father diagnosed with cancer, OR 2.17 (95% confidence interval (CI) 1.37-3.46). The finding persisted after excluding breast cancer in the family. Ductal breast cancer was associated with having a mother diagnosed with cancer. There was a significant association between lobular breast cancer and having a father with prostate cancer, OR 2.4 (CI 1.1-5.3). The occurrence of having a father with prostate cancer for lobular breast cancer patients was higher in the younger patient group, OR 2.9 (CI 1.1-7.8), and was still high but lost statistical significance in the older patient group, OR 1.9 (CI 0.5-7.4). The association between lobular breast cancer and a father remained significant after excluding fathers with prostate cancer, OR 1.94 (CI 1.20-3.14). Other commonly occurring tumor types in the father included sarcoma and leukemia.
CONCLUSION:
We propose that lobular breast cancer is associated with having a father diagnosed with cancer, most commonly prostate carcinoma. Since the association remained after excluding family history of breast cancer, the association seems independent of classical breast cancer heredity. The association with a father diagnosed with cancer also remained after removing prostate cancer, indicating an independence from prostate cancer as well. The reason for this association is genetically unclear, but could involve sex-specific imprinting.
Comments
-
This is interesting. My father had esophogeal cancer.... lived five years cancer free. He was then diagnoised with pancreatic cancer which he passed away from. My mom's side of the family has no cancer. Does anyone else have a simular situation?
-
My dad is 89 years old and still living he has only had skin cancers taken off my mom died of BC at age 54, I have been DX'd at age 58 with IDC and ILC.
Nancy
-
This is something....My Dad died from lung cancer. My Dad's side of the family has had a lot of cancer issues but nothing on my Mom's side.
Iamuso....we live about an hour apart from each other. I noticed we have a lot of similarities.
Have a good evening girls!
Balsie
-
My dad had prostate caner when he was 60 and it was cured. He went on to die of lyphoma at 82. I got lobuar cancer when ai was 49. None of my tests had genetic link.
-
Hi Balsie. Maybe there is something to this. I tested negative for the BRAC gene. They had me test when they learned my dad died of pancreatic cancer.....apparently there is a link of breast and pancreatic cancer on the father's side that relates to the BRAC gene. Nice you are so close! Are you waiting for a white Christmas also? I could really use a good old fashion blizzard. Seems we hardly see them anymore!
-
I am not sure that I fit the findings of this article. I was diagnosed with ILC at 47. I am negative for BRACA 1and 2. My mother was diagnosed at 55 with IDC with 9/17 positive nodes. She died three years later with a chemo induced leukemia. My father is living and has no history of cancer.
-
Interesting - My Dad was diagnosed with prostate cancer 6 years years ago at age 63, his brother has it too. He then got skin cancer and shortly after being diagnosed with cancer in the neck he committed suicide 1 1/2 year ago. I was diagnosed at 46 and am BRCA negative.
-
My dad and his identical twin have had prostate, bladder, bowel and skin cancer. Everyone in that family seems to get cancer, although nobody as young as me (dx at 47).
-
Lamuso~ I also tested negative for the BRAC test. Oh I want to have a white christmas but have been waiting for snow for awhile.... Love to cross country ski....hoping the Arimidex won't interfere with this. I would love to have a blizzard and enjoy a snow day from school.I have been trying to make ice candles but it is to warm. Enjoy your day everyone. I have to go get ready for my 3rd graders....it is Monday they will have lots to talk about.
Balsie
-
This is quite interesting to me and I would be so interested to hear from more ILC women. I was dx at 49, BRCA neg. My Dad had leukemia (AML) 20 years ago and went into remission then. Unfortunately he was just dx with it again and they think it was chemo induced. He is in treatment now. He was dx with prostate cancer about five years ago but it wasnt treated and it hasnt progressed. I have six distant cousins on my mother's side with BC so I always assumed a connection there. But my Dad and I really do fit this profile almost exactly like the study. Interesting though i dont know what it means...
-
Balsie how are you doing on the Arimidex? I took myself off of it two weeks ago as I was having difficulty walking....lots of pain that would get a bit better as I kept going though I never felt okay on the medicine. Getting out of chairs I felt like I was 90 years old! I went back on Tomoxifen and I will talk to my oncologist about other options in Febuary when I see him. I am in a middle school and work with DCD, EBD and Autistic students. You can feel the school climate getting crazy as we get closer to Christmas and the break. I am praying for snow!
-
Wow, you learn a lot on this site. I just want to jump in and add my 2 cents worth. I do have a friend who has ILC and her Mother also had it. Her Dad has a cardiac history but, to the best of my knowledge, no history of cancer. Due to her Dad's cardiac issues she did have a very hard time telling him that she has the same type as her Mom had, but she is doing great and so is her Dad.
SeaShelly, I am sooooo sorry for the loss of your Dad. Please accept my condolences.
Sue
-
lamuso~ I don't like arimidex at all....I too am sore, mostly in the morning once I get going it is not as bad. Getting up after sitting for a period of time is horrible. I have considered getting off of it but then I keep chugging along. My oncologist did a test and it was determined that tomoxifen would be of no benefit to me. So my choice was arimidex. Is your Dr. from duluth? I went to St. Mary's. The climate at our school is getting crazy too....the kiddos are really excited for Christmas. I too am wishing & praying for SNOW!
Balsie
-
There is a lot of cancer in my father's side of the family - I'm waiting for my BRCA test results. It will be interesting to see what it says.
-
Balsie I go to the Duluth Clinic. My oncologist is Dr. Ketchum and I really like him. Supposedly the tomoxifen should work for me but on that note....we've been waiting for my estrogen level to drop to the point I could start arimidex. I think that is the best med there is as far as keeping recurrance at bay. I may end up back on it. I discuss it with my onc. in Feb. It seemed my pain got worse the longer I was on the med. To the point I was hobbling all day long. It was hard to keep up with students at work. And forget about exercise. I just hurt too much!! On another note.....this fog in Duluth today is depressing. it feels like March...on a week and a half before Christmas.
-
OMG we have the same oncologist... I love him! I think the SE started when I went on the generic brand. The worse part is my legs and the bottom of my feet! I am thinking I should try one of the other brands of generic and see if there is any truth that the TEVA company (because of filler or whatever) causes more Se's. Dr. K really wants me to stay on Arimidex. Hey Hump Day tomorrow. So happy to meet you!
Balsie -
That is pretty funny we have the same onc. He reminds me (appearance wise) of Jim Carey the actor....ha ha! I've mentioned information I've learned on this board and he has teased me about visiting it too often and making myself stressed over things I've read. Did you do chemo or rads? I unfortunately did both because of the size of my tumor. I also had a mastectomy and about a year later I did reconstructive surgery which I am very happy with. I had a pretty good response from chemo and though my tumor didn't disappear it shrank to 2 cm. Lumpectomy was an option but I just felt the mastectomy was the better choice for me. They found precancerous cells in the supposed 'noncancer' breast so I am glad I chose to remove both. I am eager to talk to Dr. K about the arimidex and I am second guessing my choice to stop taking it. When he changed my med last visit he told me if I had side effects I should stop the drug for two weeks and see how I feel to be certain it was the drug. I am about two weeks out now from not taking it and I really noticed a difference today in the knee and leg pain. I may go back on it and see what happens during school break. I don't know a lot about the specific brand I was put on. It is Anastrozole. How did you discover your cancer? Mine went undetected for years. I never missed a mamogram from age 40 on. I was 46 at diagnosis. They figure it had been there quite a while to be that large. In the end the nurse who examined me after my mamo felt something she thought was probably nothing. Ultrasound didn't pick it up either. Was your surgeon was Dr. Parks Skinner? Anyway, biopsy confirmed my cancer. Have a nice Wednesday.....when is your last day before break?
-
He does look like Jim Carey! He also told me to stay away from this board and to leave my notebook at home....that all this was just stressing me out. Mine was not found on a mamo either. I had breast reduction surgery and they sent the tissue to pathology and four days I found out I had cancer, I too had never missed a mamogram. I then had a bilateral MX and Yes Park-Skinner did it. She is awesome....I 1st saw Dr. Tang but didn't care for him so made an appt. with PS. I did reconstruction with Dr. Messa at lakewalk. Had a great outcome except for the tats ... I didn't like the ones they did at lakewalk so I went to Lenny's in eveleth for 3D tats and wow did they turn out great. Our last day is December 22. We are gearing up for our christmas concert which is next Monday. Enjoy your day my Friend!
Balsie -
I just looked outside and it is snowing big fluffy flakes....love it
-
This is weird.....my plastic surgeon was Dr. Messa. My tats are okay. Frankly after everything I was just happy to be done. I did a lattisimus dorsi flap on my breast cancer side with implant and just the implant on the other side. It was a big recovery and I wasn't prepared for the surgery to be as hard on me as it was. I do have to say though that I chose Dr. Messa from the bunch....Parks Skinner helped me pick him and I absolutely love him too!! I've been very lucky with doctors as well as you! You are very lucky you had your breast reduction or who knows how long you may have gone with the cancer growing. We had some flakes today too but no accumulation!! Hubby says nothing predicted through next week Wednesday as far as snow. Take care balsie!
-
Well ~ we do have a lot in common.....and I was reading somewhere that you like to relax with a coors light.....me too! We will have to meet up someday in duluth. lots of fun places to hang in canal park or the patio at Sir Ben's. You have a great day.....it is Friday. We have practice today for our choir concert on Monday.
Enjoy,
Balsie
-
That would be nice..... Enjoy your last week of school before break. I am looking forward to time off with my family!
-
Got my genetic test results today - negative
-
This is interesting. My father had prostrate cancer, and I am on the younger side of BC and ILC. I am 39. I had the genetic testing done (BRCA1 and BRCA2) and tested negative. I am curious if there would be different genetic test developed that would be more specific on the prostrate/BC/ILC connection, or if the BRCA tests already do this today.
-
My father is 78, never had cancer. Has Alzheimer that is pretty much controlled by medication. My grandmother (his mother) had non-invasive gall-bladder cancer removed by surgery at the age of 58, died of Alzheimer at the age of 81. My mother is 70, never had cancer. Has only notable macular degeneration.My grandmother (her mother) had colon cancer, removed at the age of 50, died of a heart attack at the age of 72.
I had ILD, IDC and cribriform.
-
I was negative BRAC1 & 2. Half Uncle on Dad's side had possible leukemia in his 70's...life long steel mill worker. Great grandma on mother's side may have had stomach cancer...no one is sure. Heart disease and stroke on Dad's side. Little blood relatives and little history there. Mother's side lives to 90's...dying usually of respiratory or heart...old age...
I think that prostate cancer is fairly common if a man lives long enough, and was recently in the news as being over treated in milder forms.
Interesting....my theory still favors the "flipped switch" of genetic markers and environmental or ingested materials that build up and overload the cancer circuit that is in all of us...I am one of six, middle child - 2 sisters and three brothers...no cancer...Mom is one of three - no cancer, Dad was only child with 4 half siblings, and only the late in life possible leukemia in his half brother...
I was 50 at diagnosis. My sisters live in PA and have all of their lives. I lived in 2 countries and 10 states during our 20 years time in the US Navy....we lived near the Ocean in Italy and they did not filter what went in the water there in the 80's...Cuba's ocean waters were clean as far as I knew but what the base dumped on land is anyone's guess...There is a study showing a high rate of breast cancer, I believe in males associated with time served on a NC Base...
Interesting stuff at any rate, thanks for sharing.
-
congrats susieq.... You were lucky to be diagnoised early on in your prognosis!
-
I was very lucky the ILC was found so early, but not so lucky that it was HER2+ve - a very rare event I believe.
-
Wow. Just discovered this thread. My dad died last month of colo-rectal cancer BUT he had prostate cancer 16 years earlier---and there's speculation that over-radiation caused the colorectal. His father and brother both died of cancer- one pancreatic, one kidney.
I was dx'd with lobular in 2005 at age 52 (and just had a Mx/Recon for DCIS in the same breast). Tested negative for BRCA. Genetic counselor said there was probably a "familial" connection nonetheless, because of my father's family. And that future tests might identify more of these kinds of genetic mutations.
OTOH, my sister is 63 and has never had cancer. So who knows. And yes,both prostate and breast cancer are so common that a link is not surprising...
-
lamuso~ I know you have trouble with the SE's of Arimidex and wanted to share a product that is really helping me with the SE's of that....it is called Reumofan Plus and is an over the counter product with all natural ingred. I have taked two pills and can really feel a difference. It is only 25$ a bottle. When I got up this morning I could not believe the difference in how I was getting around, Not feeling 90 anymore.I called Ketchum and he said to try it. 3 more days til christmas break!!!
Enjoy
Balsie
Categories
- All Categories
- 679 Advocacy and Fund-Raising
- 289 Advocacy
- 68 I've Donated to Breastcancer.org in honor of....
- Test
- 322 Walks, Runs and Fundraising Events for Breastcancer.org
- 5.6K Community Connections
- 282 Middle Age 40-60(ish) Years Old With Breast Cancer
- 53 Australians and New Zealanders Affected by Breast Cancer
- 208 Black Women or Men With Breast Cancer
- 684 Canadians Affected by Breast Cancer
- 1.5K Caring for Someone with Breast cancer
- 455 Caring for Someone with Stage IV or Mets
- 260 High Risk of Recurrence or Second Breast Cancer
- 22 International, Non-English Speakers With Breast Cancer
- 16 Latinas/Hispanics With Breast Cancer
- 189 LGBTQA+ With Breast Cancer
- 152 May Their Memory Live On
- 85 Member Matchup & Virtual Support Meetups
- 375 Members by Location
- 291 Older Than 60 Years Old With Breast Cancer
- 177 Singles With Breast Cancer
- 869 Young With Breast Cancer
- 50.4K Connecting With Others Who Have a Similar Diagnosis
- 204 Breast Cancer with Another Diagnosis or Comorbidity
- 4K DCIS (Ductal Carcinoma In Situ)
- 79 DCIS plus HER2-positive Microinvasion
- 529 Genetic Testing
- 2.2K HER2+ (Positive) Breast Cancer
- 1.5K IBC (Inflammatory Breast Cancer)
- 3.4K IDC (Invasive Ductal Carcinoma)
- 1.5K ILC (Invasive Lobular Carcinoma)
- 999 Just Diagnosed With a Recurrence or Metastasis
- 652 LCIS (Lobular Carcinoma In Situ)
- 193 Less Common Types of Breast Cancer
- 252 Male Breast Cancer
- 86 Mixed Type Breast Cancer
- 3.1K Not Diagnosed With a Recurrence or Metastases but Concerned
- 189 Palliative Therapy/Hospice Care
- 488 Second or Third Breast Cancer
- 1.2K Stage I Breast Cancer
- 313 Stage II Breast Cancer
- 3.8K Stage III Breast Cancer
- 2.5K Triple-Negative Breast Cancer
- 13.1K Day-to-Day Matters
- 132 All things COVID-19 or coronavirus
- 87 BCO Free-Cycle: Give or Trade Items Related to Breast Cancer
- 5.9K Clinical Trials, Research News, Podcasts, and Study Results
- 86 Coping with Holidays, Special Days and Anniversaries
- 828 Employment, Insurance, and Other Financial Issues
- 101 Family and Family Planning Matters
- Family Issues for Those Who Have Breast Cancer
- 26 Furry friends
- 1.8K Humor and Games
- 1.6K Mental Health: Because Cancer Doesn't Just Affect Your Breasts
- 706 Recipe Swap for Healthy Living
- 704 Recommend Your Resources
- 171 Sex & Relationship Matters
- 9 The Political Corner
- 874 Working on Your Fitness
- 4.5K Moving On & Finding Inspiration After Breast Cancer
- 394 Bonded by Breast Cancer
- 3.1K Life After Breast Cancer
- 806 Prayers and Spiritual Support
- 285 Who or What Inspires You?
- 28.7K Not Diagnosed But Concerned
- 1K Benign Breast Conditions
- 2.3K High Risk for Breast Cancer
- 18K Not Diagnosed But Worried
- 7.4K Waiting for Test Results
- 603 Site News and Announcements
- 560 Comments, Suggestions, Feature Requests
- 39 Mod Announcements, Breastcancer.org News, Blog Entries, Podcasts
- 4 Survey, Interview and Participant Requests: Need your Help!
- 61.9K Tests, Treatments & Side Effects
- 586 Alternative Medicine
- 255 Bone Health and Bone Loss
- 11.4K Breast Reconstruction
- 7.9K Chemotherapy - Before, During, and After
- 2.7K Complementary and Holistic Medicine and Treatment
- 775 Diagnosed and Waiting for Test Results
- 7.8K Hormonal Therapy - Before, During, and After
- 50 Immunotherapy - Before, During, and After
- 7.4K Just Diagnosed
- 1.4K Living Without Reconstruction After a Mastectomy
- 5.2K Lymphedema
- 3.6K Managing Side Effects of Breast Cancer and Its Treatment
- 591 Pain
- 3.9K Radiation Therapy - Before, During, and After
- 8.4K Surgery - Before, During, and After
- 109 Welcome to Breastcancer.org
- 98 Acknowledging and honoring our Community
- 11 Info & Resources for New Patients & Members From the Team