nuclear pleomorphism score??

Rayhope,

Not necessarily-- Do you have a copy of your pathology report??  You need more info -- Nuclear grade is different than the subtype-- looking at my pathology report it was described as invasive lobular carcinoma, pleomorphic type--it then described the grade as a level two.

If it is Pleomorphic... ask your oncologist what this means... I personally received much shrugging of the shoulders  as far as prognosis and difference from classic

Great news on no nodes-- How were you HER2+ tested... ICH??  Consider requesting the Oncotype dx notwithstanding the size of your tumour --- it also tests for Her2 now

Lobular tumours tend to be larger for a number of reasons  here are 2--...1. harder to detect (which certainly happened in your case) and 2. the shape of the tumour tends to be ameoba like not a nice little oval -- so measurement actually is oversized.

Hang in there

rayhope,  I don't know that you have pleomorphic lobular unless it says "with pleomorphic features" or "with features of pleomorphic lobular carcinoma".  Pleomorphic is a subtype of lobular. The nuclear pleomorphism is just that, part of the grading of the cells, not a cancer phenotype.

 I have read some old studies where anyone with Grade 2 or 3 ILC was called pleomorphic lobular because classic lobular is usually grade 1.  

A newer study I read recently is looking at genetics of lobular. They have divided it into "classical" and "other" and seem to feel that half of ILC cases fall into each category.  Pleomorphic is within the "other" category.  They are finding that the "other" type of ILC is more prevalent than they thought, but isn't always obviously pleomorphic, so not so easy to identify without gene testing.  I think it's important to know this, because it could just be that the "other" category of ILC might benefit more from chemotherapy than the "classical".  I hope they do more of this research; it could really help the ILC women make treatment decisions.

I can't find the link, can you repost?