HER2- FISH results

Options
bojo
bojo Member Posts: 74
edited June 2014 in HER2+ (Positive) Breast Cancer

Hi everyone, i need help with my FISH results.  My orginal results for HER2  was a 2+.  so they sent it out again to get a FISH testing?  This is what the report says.

Can anyone tell me if i am HER2-Positive or Negative?

I got my FISH results back on the HER2 -2+ original number

Finding:

Antibody         Results             Intensitey

ERA (SP1)     100%                 moderate

PRA (1e2)      95%                   strong

HER2 (4B5)       2+

Ki67               12%

E- Caderin                see interpretation 

Fish Probes                         Results                             Interpretation

HER2 & CEP-17 FISH             1.7                                 unamplified

Interperpretaion

HER@ Fish results for Clarient:

Block examined C6

# of cells examined 20

# of fields examined 5

her2/cep-17 ratio 1.7

total HER2 count 91

average her2 count 4.6

max her2 count 7

total cep17 count 55

average cep-17 count 2.8

postive (amplified)= >2.2

equivocal = 1.8 - 2.2

Negative (not amplitfied) = <1.8

· Share on FacebookShare on Twitter

Comments

  • LouLou40
    LouLou40 Member Posts: 180
    edited December 2011

    I'm no expert just from the interpretation on your report  result is 1.7 unamplified.

    Negative (not amplified) = <1.8 - therefore you are considered neg for Her2 by the FISH test.

    I had a friend dx at the same time as me Her2+ showed 2+ and tumour was sent for FISH which came back negative and therefore she received no herceptin with her chemo, unfortunately she developed a single bone met about 6 months post chemo and her original tumour was retested for Her2 and it was then reported positive, so now she is on Hercepin indefinitely. 

    Definately discuss with your Onc and push for Hercptin if any suggestion your Her2 + 

    · Share on FacebookShare on Twitter
  • dragonfly1
    dragonfly1 Member Posts: 766
    edited December 2011

    bojo According to what you've posted it definitely sounds negative (the test range you've listed shows anything less than 1.8 as negative, 1.8-2.2 as equivocal and 2.2+ as positive)

    · Share on FacebookShare on Twitter
  • bojo
    bojo Member Posts: 74
    edited December 2011

    LouLou,

    Thank you, that's what i thought, but was thrown off by being HER2 2+ then being so close to the range.  This path is from my first surgery 11/21, I went in thinking i had pure DCIS, turned out there was a very small amount of invasive cancer.  I now have to go back in the 12th to get a clean margin and they are doing a sentinal node biopsy.  Hopefully all goes well and i will have no nodes. 

    Dragonfly1

    Thanks for your reponse, that's what i thought too.

    · Share on FacebookShare on Twitter

Categories