Taxol vs. Docetaxel
I was switched from docetaxel every 3 weeks (after the first tx), to taxol every week for 9 weeks.....because the SEs all but killed me with the first dose of docetaxel, my onco said it would be a lower dose and the SEs should be minimal.
I'm curious if I should still ice my hands and feet like I did for docetaxel, although I have to say my toenails are still sore 3 weeks after the docetaxel tx. I couldn't put my shoe on my left foot today my big toe was too sore.
Also, anyone else that has done docetaxel and taxol, possibly in the lower weekly doses..comparison of SEs?
Thanks!
Comments
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Anyone ??
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I am bumping this again, hoping that someone can help out
My hair is trying to grow back on the taxol, I have 5 tx left, including today, and I noticed my hair is about an inch thick and seems to be trying to grow back, anyone else have this happen in taxol? My eyebrows and lashes are all but completely gone....hair under my arms is coming back a very sparse peach fuzz too!
I have some bone pain, off and on and seem to be getting more and more tired each week. The other problems are much slighter on taxol, although the tingling and numbness in my fingers and toes is annoying, I do take B6 and Acetyl L Carnetine, hoping that is keeping it at a minimum.
Just curious how this compares to others on taxol.
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Ellen I never did taxol but mine grew back (slowly) on Abraxane after AC. Sorry I can't help you (well not really sorry because that would be one more chemo for me and I'm glad to be done with that for now lol).
Hope you get some answers soon. -
I'm sorry you didn't get any answers. I'll be curious to see what responses you get. I may be switched from Carbo, Taxotere, and Herceptin every 3 weeks to Carbo alone followed by weekly Taxol+Herceptin. I was also told the SE's would be easier. Interesting though, when I told my onc. my nails were feeling loose, she told me to avoid very cold or very hot water. I haven't researched anything about icing them.
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YES!! Continue to ice your hands and feet. Docetaxol, taxotere, taxol....my cancer centre provided ice mitts and booties during treatment.
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Taxol should be much easier to tolerate than taxotere, but I would keep icing. And yes, the hair on your head will start coming back on Taxol (so strange, isn't it?), though in my experience with both taxol and abraxane, the hair that first comes back is fuzzy/downy soft, not-exactly-like real hair. But eventually it will go back to normal.
I hope the taxol gives you less side effects. Take care,
NancyH
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My hair started to grow back while I was on the Docetaxol, but Nancy is right, it was all sort of fluffy and colourless. The docetaxol wiped out all brows and lashes that I had left too - that was odd - since I was growing hair on my head!
I iced my hands and feet through treatment (which ended in Feb). I thought I had avoided any nail issues, but by the end of the summer, I still lost one big toenail and it looks like I may use one of my baby finger nails. They just kind of came unattached.
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thanks everyone!! and Reesie you are right, you should not be sorry LOLOL
I haven't been icing, so I'm thinking next time and for the next 4 I will....
hugs everyone!!
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Ice Ice Baby !!
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do you all think it will help if I didn't ice the last several but start back up for the last 4? Is it wasting my time as I've already got some numbness going on....and taking some supplements....
Thanks!!!!
LOL @ Ice Ice Baby LOLOL
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anyone switched from Docetaxel to Pactitaxel ??
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Question on icing... I just had my first dose of weekly taxol x12. Does the icing help with the nail issues or the neuropathy issue or both? Do you ice just during the treatment or have to start prior and continue after for it to be effective? My clinic doesnt seem to offer icing of hands and feet, although they did have me do the ice chips or a popcicle while on AC. Is the icing of your hands and feet tolerable though the treatment? Thanks!
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hi ccjj
I iced my hands and feet when on docetaxel, I used bags of veggies...it was very tolerable. The docetaxel was too rough on me so they switched me to taxol.
I am going to ice the last 4 txs of taxol....
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I was first given taxotere but had a reaction to it. Then did 4 DD of A/C. Now after surgery and finding cells in the nodes I will have to do the taxol. I see that some women do weekly treatments of taxol instead of every 3 weeks. I'm really concerned about taxol since I have had one reaction with taxotere. Also the neuopathy bothers me. I type for a living and play the piano for church. How bad is neuropathy? Would I still be able to type and play the piano?
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ccjj = icing is for nails, both fingernails and toenails. I recommend icing every tx, from 15 minutes prior to whatever taxane you are given, until 15 minutes after that portion of your tx is done. I brought 4 bags of frozen peas from home, and held ice chips in my mouth as well. My center did not offer any ice but had no objection to bringing my own. It is not particularly comfortable and you may be cold, but having painful and problematic nails isn't comfortable either. If you have concerns about neuropathy, I would ask your onc about whether they are ok with you supplementing with B6 - one caplet, Acetyl L-Carnitine - 500 mg, and L-Glutamine - 30g of powder a day, 10g x 3 daily - I dissolved it in a hot drink. Neuropathy varies per patient, some people have none, some have it mildly and it dissipates after treatment is done, and some people have it severely and permanently. Unfortunately, it is impossible to predict who will have problems. You may do better with weekly taxol since it is a smaller dose each time, then every 3 weeks with a large dose.
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capinva, I too had a very bad reaction to docetaxel (the generic for taxotere) and with the weekly smaller doses of taxol have been ok.
SpecialK, thanks so much for all the great info! Do you recall if after 4-5 txs you felt a bit worse? The bone pain is hit or miss, comes in spurts but there was almost none in the beginning. The mouth sores and tiredness seem to be worse after each tx.
Pearly, docetaxel and paclitaxel (taxol) are both taxanes, from the same family.
Off to bed, nite all
hugs and kisses!
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I did the 12 week regimen of Taxol (after AC). The tiredness got progressively worse with each TX, but I worked full time and pretty much lived a normal life except for going to bed really early (like 7:30pm) and spending most evenings and weekend afternoons on the sofa. I had body pain only sporadically and it never got worse than feeling like I'd excercised a bit too much. I started getting some neuropathy in my fingers at about week six. The Onc reduced my dose and it went away. Never had mouth sores, but my taste buds took a hike and everything tasted way, way too salty or way, way too sweet. All these SE's disappeared quickly once I was done.
Good luck to you ladies...you can do it!
Patty
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rabbit - #5 was my worst, but #6 was a piece of cake - I waited for the SE but they never came. I did the 6 tx every 3 weeks of TCH. I was just very fatigued. I am still receiving Herceptin and still have some fatigue and mild SE from Herceptin, like stuffy/runny nose, sometimes GI issues, and some stiffness, but nothing major.
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thanks all for the info
I just had taxol #6 Wed. I am more exhausted than ever, I feel like a truck ran over me, and I feel like every muscle and bone in my body is inflamed. I am getting weekly tx of taxol, 3 more to go.
msmpatty, I have no idea how you worked full time during this, I would never of been able to do that. I work from home and just to get on the computer and get a few hours of work done tires me out. But I know everyone is affected differently.
I iced this time and plan on doing it the last 3x. My right hand thumb nail is peeling off from the back to the front, my left middle finger is about 75% lifted and discolored, I can't wait for this crap to end! I have neuropothy mildly in my hands and feet, I told the onco and he said that's part of it....I guess I have to deal with it. Maybe because my tx plan was to have the docetaxel and I had a bad reaction to it, with switching me to taxol weekly, he probably wants to make sure I finish this one out, Dec 7th can't get here soon enough!
hugs to everyone!
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Sorry you are struggling. You are almost done though, hang in, you can make it! Pretty soon you will be looking back at this instead of miserably looking forward.
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thanks SpecialK
I know you are right!
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ok, yesterday was my last one. Onco reduced the last taxol due to my neuropathy..he almost convinced me to not take it all, but I didn't want to regret it down the road so we agreed on just reducing it. I've lost 2 fingernails completely, one toe nail completely. One fingernail is halfway off....6 are lifted almost halfway and only one fingernail looks like it might live. And most of my toenails look okay...I iced every time since I posted except this last one.
A few questions, my hair has been coming in like peach fuzz for most of the taxol txs, how long after taxol does it take to start growing normally? And eyelashes and eyebrows? I've been penciling mine in for months now...and lastly, taste buds, anyone remember when you get your taste buds back? Mine have been shot for months, I may get one day, the day before taxol, where I can almost taste stuff.
Hugs to all!
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I'm bumping this, hoping someone can help me with the other questions
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Hi! Bumping this topic, because I'm considering asking MO about taxol instead of taxotere starting next week. Have already done 3 FEC, nervous about new and daunting SEs and longterm SEs. Any thoughts welcome!!!!
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After reading all of this it helps me mentally prepare that things are going to suck. All of my work clothes are hemmed to wear with high heels. I'm mentally preparing for all the issues I could have including major wardrobe challenges. I've lost 15 lbs and none of my work clothes fit but I have taken a couple pairs to a cheap seamstress as next to my health, and trying to keep my relationship intact, $$ is my biggest issue...hence trying to figure out how to get it together to go back to work in June!
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Hey there, I learned after the fact that the eye brows and eye lashes are on a different growing cycle than the hair on your head. I lost my brows and eye lashes after AC while I was on taxol and herceptin. I still lose then occassionally. Don't worry. Once you get peach fuzz your hair will start growing back fairly quickly. You will however have uneven hair growth. I had to have a few appointments just to get everything gowing at the same time. And don't be surprised when your hair comes back either curly or straight. You have no idea what you are getting. Mine came in very dark and curly. It has stayed curly.
You are on the road to recovery. Your lashes and brows should start coming in but they will come and go for a while longer. Shorter life cycle I guess. Hange in there.
sorry to hear about the nails. Definately keep icing as it really helped me.
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KCB, for my experience, Taxol was MUCH easier than Docetaxel (the taxotere group I think) The worst part about the Taxol was the accumulative tiredness and the neuropathy, which I still have to some degree.
Mariasnow, which chemo will you be doing? You confused me when you said you were going back to work in June, did you already have surgery?? Good luck and hugs!
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hi all
Did you try a diet rich in frolic acid to help with hair and nails?
My wife has been has been making an apple and carrot smoothie or similar every morning and she only lost a bit of hair, but the slight hair loss might be due to just having another baby as she lost quite a bit of hair after our first baby.
Her nails and eyebrows are fine.
Our Onc was surprised as he says most lose hair on docetaxel.
I'm on the smoothies myself now but still balding.
Best wishes
Bp
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