ER+/PR- HER2- anybody else?

In contrast to the statements on the last link, from what I've read, not all PR- tumors are tamoxifen resistant but many are, particularly those in which EGRF and/or HER2 are elevated. I am going to ask whether it might be worthwhile to have my ovaries taken out and go onto AIs instead, though.  My EGRF is not elevated, though - but I have a KI-67 score of 50%.

here's a thought--if indeed it is like triple negs doesn't that mean that the recurrence rate drops dramatically after 3 years (I feel like I read this somewhere at some point-- that the triple negs recur mostly in the first 3 years-or did I make that up?)

this is so confusing--my pathology from both hospitals was er/pr+ but on the oncotype, it was ever so slightly pr-  My onc did not think it was a big deal--- but I will bring it up again in November.....

sigh.

momand2kids, I LIKE that idea! I will hold onto that.

   Yes same with me .PR on pathology said 60% but onco said negitive. None of the drs seem

to undrstand only said different labs.. surely it can  not be that much difference..

I have read also about neg PR being aggressive.

Maymom, your cancer sounds very similar to mine except that mine was grade 1, not 3.  I was treated with a lumpectomy and radiation, didn't need chemo. Tamoxifen was recommended but I declined out of fear of the side effects. I didn't want to increase my risk of getting other serious illnesses besides breast cancer.  I know tamoxifen can cause strokes, cancer of the uterus and other serious problems.

I"m fortunate that I was grade 1.  The oncologists told me that being grade 1 puts me in a category that is not high risk for recurrence, and if a recurrence does happen, it will most likely be a local recurrence, not a metastasis. So now I am being checked every 6 months.

I dont personally think you should put all your chips in on the Oncotype DX.... I am ER+/PR- and HER2- and no lymph node involvement.  My margins were also clear which kept me in Stage I.  The first Oncologist i saw wanted to wait and see what my Onco score was...i decided to get a second opinion....the next Oncologist i met was wonderful!! he explained that Chemo shouldnt be a question and that the Onco test doesnt matter because of my age (29) I did have it ordered already so i did get my results.  He explained the Onco test is only shows your likely hood of reoccurance in a ten year span....if you have more than 10 years to live i would recommend the chemo.... it will keep your chances of cancer returning lower your entire life... Also the Onco tests are not FDA Approved for testing for Her2, i would recommend the FISH test. it is one of the only two tests approved by the FDA. There are numerous reports of fasle Her2- reports from OncoDx.

I am doing my second treatment of TC next week.  My hair just started falling out.  I do my treatments on Thursdays so i stay home friday and work half days monday and Tuesday.  I start to feel back to normal and got my taste buds back about 1 week later.  Remember to rest and stay stress free during chemo...the more you exert your self the harder it is on your body.  And remember eat lots of protein!! My labs keep coming back lower and i need to do a better job resting and eating more protein! Good Luck Ladies...we didnt ask for this battle but we will concur it!

Florida55 being HER- is a good thing. If you were HER+ they wouldn't even do the oncotype test, because you would be high. Good luck I hope you get a nice low score. I was right in the gray zone with a 24, which isn't a nice place to be. They leave the decision up to you which is very hard.

If you have any questions just ask away. There are always lots of poeple who will give lots of good advice.