Complementary and integrative approaches

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  • Kymn
    Kymn Member Posts: 999
    edited July 2011

    Thank you Sherri and the Newme I will check out that website you suggested thenewme.

    Mollyann that is interesting about Curcumin,do you take it?If so how much?How often?

    shirley that would be very much appreciated I look forward to hearing from you

    Kymn

  • Sherryc
    Sherryc Member Posts: 5,938
    edited July 2011

    I don't post here much but love reading all the info that you gals do post.  I am new at all this and learning so much.  Thank you for posting what you have learned so far.

  • Member_of_the_Club
    Member_of_the_Club Member Posts: 3,646
    edited July 2011

    The internet is full of advice from and to body builders about abusing Arimidex but that is really separate from taking it to treat breast cancer.  Keep in mind that those are men taking it, and not under a doctor's supervision.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited July 2011

    Sherri, what is your plan after the Femara ? Edited to add Hi Sherry !

  • Heidihill
    Heidihill Member Posts: 5,476
    edited July 2011

    That's an interesting study, SherriG. I took a one-month break from Femara last year because of pain issues. I went back on it once all the pain was gone. This year I don't have that much pain anymore, so I'm wondering whether to take another break for "estrogenic stimulation." Or should I wait until Femara fails? Just wondering out loud. I am almost 4 years out from Stage IV diagnosis and have been NED over 3 years.  In the meantime, I am exercising daily to reduce my estrogen levels. I suppose that's akin to taking a higher dose of Femara. But unlike Femara, exercise also reduces inflammation and releases endogenous opioids.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited July 2011

    I have come across recommendations to cycle out our supplements, that after three months, it's better to stop and restart one month later, I suppose to prevent "drug" habituation.

    habituation

    1. A form of nonassociative learning characterized by a decrease in responsiveness upon repeated exposure to a stimulus compare SENSITIZATION

    2. Physiological tolerance for a drug resulting from repeated use.

    3. Psychological dependence on a drug resulting from repeated use.

  • pip57
    pip57 Member Posts: 12,401
    edited July 2011

    I have no sources to back up this thought, but, I would be concerned that the cell could become resistant much like it does when you start and stop antibiotics.  Anyone have info on that?

  • kira1234
    kira1234 Member Posts: 3,091
    edited July 2011

    Luan, Could you share where the info came from?

  • Anonymous
    Anonymous Member Posts: 1,376
    edited July 2011

    Lactic acid found to fuel tumors

    A team of researchers at Duke University Medical Center and the Université catholique de Louvain (UCL) has found that lactic acid is an important energy source for tumor cells. In further experiments, they discovered a new way to destroy the most hard-to-kill, dangerous tumor cells by preventing them from delivering lactic acid.

    http://www.physorg.com/news146421554.html

    A Yale study challenges oncology researchers to consider tumor cell hybridization with white blood cells as a major reason cancer metastasizes

    "Cancer cells exhibit a remarkable number of traits normally attributed to white blood cells known as macrophages, including the ability to migrate to lymph nodes and distant organs and to form a new blood supply," said lead author John Pawelek in Yale's school of medicine. "Our data indicate they do this by hybridizing with macrophages."

    http://www.physorg.com/news8989.html

    Low Oxygen Recruits Inflammatory Cells to Tumors, Stimulating Growth

    http://www.physorg.com/news191092873.html

    New strategy to attack tumor-feeding blood vessels

    http://medicalxpress.com/news/2011-06-strategy-tumor-feeding-blood-vessels.html

    Does food act physiologically like a 'drug of choice' for some?

    http://medicalxpress.com/news/2011-07-food-physiologically-drug-choice.html

  • Anonymous
    Anonymous Member Posts: 1,376
    edited July 2011

    Kira, thank for asking, I was extrapolating, no more, no less. My post was only defining what habituation is, but found this about chemo and how the degree of sensitivity varies from highly sensitive to resistant.  It would appear that we are treated on a one-size fits all basis, as I was not tested whether I was sensitive or resistant to TAC.  Has anybody here been tested other than weight and appearing healthy or not ?

    Will keep looking whether similar studies have been done about Tamox and AIs, but can't promise....

    "Mechanisms of Drug Sensitization to TRA-8, an Agonistic Death Receptor 5 Antibody, Involve Modulation of the Intrinsic Apoptotic Pathway in Human Breast Cancer Cells

    Conclusion: Targeting these proteins with novel agents sensitized TRA-8-resistant breast cancer cells, suggesting this approach may represent a potent therapeutic strategy in the treatment of breast cancer"

    http://mcr.aacrjournals.org/content/9/4/403.abstract

  • Anonymous
    Anonymous Member Posts: 1,376
    edited July 2011

    Sherri, I think you meant to reply to me ?  Are they now doing sensitivity tests for chemo response in your neck of the woods ?

    You say lower grade cancer doesn't respond well to chemo ?  I was I told that my grade 1 trumped a grade 3, don't get it ?  Sooooo much research to do !!!!!  What grade were you ?

    My tumours were ductal with lobular features which classifies me in a very low percentage on the scale. Any "remnants" from TAC ? Frown

    Am so glad to have found a TAC sister, why are they so rare, I have to wonder.  So many questions !!

  • kira1234
    kira1234 Member Posts: 3,091
    edited July 2011

    Luan, I would love to know if desting is being done before giving chemo. I'm putting a link here that has a good article and some interesting responses from people here. One of the things being discused is about testing the tumors.

    http://community.breastcancer.org/forum/67/topic/771836?page=1#idx_4

  • Anonymous
    Anonymous Member Posts: 1,376
    edited July 2011

    Novel Citrus Extract Blocks Deadly Cancer Cell Signaling

    "Suppose instead you could disrupt cancer cells' lines of communication sufficiently to slow and prevent their proliferation, leaving healthy cells untouched?

    Avant-garde cancer researchers are finding that a proprietary form of citrus pectin possesses this capability"

    http://defeatosteosarcoma.org/2011/07/novel-citrus-extract-blocks-deadly-cancer-cell-signaling/

  • Chevyboy
    Chevyboy Member Posts: 10,786
    edited July 2011

    Merilee!  Hello again.....  I was wondering, are you still taking Tamoxifen?  I tried looking for the answer on this thread, but couldn't find it... And if you are not,  could you please tell me what you are taking instead of ??

    And how is your hearing?   Has anything improved? 

  • Anonymous
    Anonymous Member Posts: 1,376
    edited July 2011

    Thanks Kira, those links never work....what words did you use in your search ?

  • kira1234
    kira1234 Member Posts: 3,091
    edited July 2011

    I didn't realise they don't work. Just copy and paste then it will work.

  • kira1234
    kira1234 Member Posts: 3,091
    edited July 2011

    It's the new york article in the stage 3 thread Luan.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited July 2011

    Good news for future chemo girls (can I post this on the Just Diagnosed Thread ?) am sure can't hurt the old girls either...

    Effect of PYCNOGENOL on the toxicity of heart, bone marrow and immune organs as induced by antitumor drugs

    http://defeatosteosarcoma.org/2011/06/effect-of-pycnogenol-on-the-toxicity-of-heart-bone-marrow-and-immune-organs-as-induced-by-antitumor-drugs/

  • Anonymous
    Anonymous Member Posts: 1,376
    edited July 2011
  • Anonymous
    Anonymous Member Posts: 1,376
    edited July 2011

    Sorry girls if I've been blasting you  !!

  • kira1234
    kira1234 Member Posts: 3,091
    edited July 2011

    Well Luan, I will say you"ve been very busy. It is interesting info though.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited July 2011

    "What should breast cancer patients eat during Taxol (paclitaxel) chemotherapy?

    We caution against taking curcumin (aside from the study above, I guess), EGCG, GLA, I3C, DIM, luteolin, quercetin or resveratrol in supplement form because of the possibility of unintended consequences. Safe and effective dosages for these supplements during chemotherapy have not been established."

    http://defeatosteosarcoma.org/category/generalcancerresearch/cancer-types/breast-cancer/

  • kira1234
    kira1234 Member Posts: 3,091
    edited July 2011

    SherriG, I didn't realize most ILC was grade 1. I really wish more Onc's understood ILC. What I find is we are treated just like IDC. When I first  found out I had BC I didn't realise it was so different.

  • kira1234
    kira1234 Member Posts: 3,091
    edited July 2011

    I know mine went from a grade 2 to a 1. The biopsy was tested locally, but the final path was done at Moffitt. It sure makes a difference to be treated by a teaching hospital.

    What a shame he isn't still working on ILC. We need more research done on ILC.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited July 2011

    Wow, that's pretty amazing about the sensitivity testing, not here yet, sheeshh, did not realize we were soo far behind Cry  If I tell this to my onc, guess what, he'll say "we don't know", bugger.

    Thanks for the bad and the good news in your post :0

    TAC was/is a monster, but Tamox is not far behind for me at least.  I believe I have very high sensitivity to meds, never took them, unless I had a realllll bad headache.  So yeah, having gotten the "one size fits all dose" hit me like a tornado.

  • kira1234
    kira1234 Member Posts: 3,091
    edited July 2011
    Luan I agree T/C as a monster. I was only able to take the 1st dose. It almost killed me. I've always felt if I had more doses rather than the dose dense one I could have gotten them all.Cry
  • kira1234
    kira1234 Member Posts: 3,091
    edited July 2011

    SherriG, How is TAC different than TC. 

  • kira1234
    kira1234 Member Posts: 3,091
    edited July 2011

    I know my Onc. and I have discussed what will happen if the cancer comes back. I will be treated very conservativly, but don't really know what that means. It's funny when I look back I know I spent time in the hospital for the infection and radiation burns, but what I really remember was the extreme head pain and eye sight going in and out.. Everytime I remember that first Oncs comment what do you thing you have brain mets it makes me sick.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited July 2011

    Kira, don't cry coz you didn't get TAC, Lol.....An onc actually said that to you ???

    Sherri, yeah Taxotere which is leaving me with major major hair regrowth problems, I hate it with a passion Cry  I woud have given up my breasts if I had been warned and known that this would happen.

    Can't figure it out.  The NCC guidelines prescribe TAC in my case, yet I've read that adryamicin does not work on ER+.  WTH ??

  • kira1234
    kira1234 Member Posts: 3,091
    edited July 2011

    Taxotere is a nightmare drug. Yes she said that to me. Before that happened I should have realised I should find someone else. Her feelings were very obvious. She didn't like my going to Moffitt felt local surgeon would be fine hay it was such a minor tumor! Didn't like mammasite didn't know any one who had had it done ect. What a fool I was.

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