pathology questions

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Frankenboobs
Frankenboobs Member Posts: 36

I'm newly diagnosed - 5.25/11 - and opted for a bilateral skin-sparing mastectomy with immediate reconstruction. I had the surgery and the TE's on 6/16.

 When I started out, it was believed this was a stage 1 IDC that would require no chemo, or rads since I was going for the bilat, and there was no obvious nodal involvement.

Pathology, I'm pretty sure, indicates differently.

The IDC tumour is 2.4cm, with DCIS making up approximately 25% of the tumour size. I'm not sure what that means. The tumour is grade II/III... do I assume that's a 2 out of 3? It's rated this way: Architecture 2, Nuclei 2, Mitoses 2.

Focal angio-lymphatic space invasion around the margins of the tumour.

It's ER+/PR+

DCIS - Predominately Comedo Necrosis type with micropapillary areas.
Nuclear grade III/III
Non-extensive high grade DCIS confined to the tumour, making up approximately 25% of the tumour mass.

Sentinel Nodes: 2 were taken and biopsied. One was benign. The other tested positive for a 2.5mm metastatic deposit of tumour - no extranodal extension identified.

 I know that all of this changes the game but since I have no real idea what a lot of this means, I don't know what changes. Can anyone help me sort this out?

Thanks for any input.

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  • chrissyb
    chrissyb Member Posts: 16,818
    edited June 2011

    Hi Nyte Magic, sorry you need to be here but glad you found us, welcome.  I am not a doctor but my reading of your pathology report is as follows,

    Your IDC (Invasive Ductal Carcinoma) is approx. 2.4cm in size and of that 2.4cm, 1/4 of it is DCIS (Ductal Carcinoma In Situ = in the duct itself rather than outside the duct).

    The next portion deals with how aggressive the cells are and the way they have written it, Grade II/III, is telling me that they are more aggresssive than II but not as aggressive as III but I think your doc will probably err on the side of caution and treat as if it were straight Grade III.

    Focal angio-lymphatic space invasion around the margins of the tumour means that cells have invaded the lymphatic system which means cells have travelled.  The fact that you have one node involved says that the lymph node did it job and caught those cells.

    ER+/PR+ means that Estrogen and Progesterone both feed your tumor.

    The rest is dealing with the type of DCIS but that is not the most important part and for you, not the part that the doc will base your treatment on.  IMHO you will probably need chemo because of the lymphnode being positive but I don't know about rads and you will probably be on one of the hormals for the prescribed 5 years.

    As I said before, I am not a doctor that is just my understanding.  Hope it helps.

    Love n hugs.  Chrissy

  • Frankenboobs
    Frankenboobs Member Posts: 36
    edited June 2011

    Thanks so much, Ladies, for helping me understand my diagnosis. I now have a clearer vision of what all of this means for me and with that better understanding comes some relief. My BS and PS have been talking like rads are a given and chemo will be up to the oncologist.

     Britchick, I have no idea what what my HER-2 status is. That was sent out for additional testing after the biopsy since it wasn't clear one way or the other. I was told it was ER+/PR+ at that time though and that I'd require 5 years of hormone therapy when all was said and done.

    I also know that due to the location of the tumour and the fact that they're not comfortable with the margins on the side closest to the skin, I will have to undergo an additional surgery to excise that tract of skin. It's located over the expander right now.

    I don't think we have Oncotype DX testing here in Canada. I'm not sure what criteria they base the need for chemo on, though I suspected I would be offered that since there was a lymph node involved. My BS doesn't feel there's a need to remove the axillary nodes since there seems to be no other nodal involvement - no swollen or painful nodes anywhere. She's taking a bit of a "wait and see" approach to that. I guess much will depend on what the oncologist has to say.

    Technically, my actual outside the duct tumour is 1.8 cms then?

    I must admit that part still confuses me.

    I'm off to have the second drain pulled soon. I can't wait to have that nuisance gone!

    Thanks again for helping, and for the welcome. It's not a club anyone wants to join but wow, it's awesome to have a place to go where others genuinely understand!

    Kiss

  • chrissyb
    chrissyb Member Posts: 16,818
    edited June 2011

    Glad I could help.  Good luck with your doc visits and I also think you are in good hands.

    Love n hugs.  Chrissy

  • Frankenboobs
    Frankenboobs Member Posts: 36
    edited June 2011

    Thanks again to both of you.

    I'll definitely check into the Oncotype testing, Britchick, and thank you for helping to clear up the tumour confusion. That test hasn't been suggested or offered but perhaps it's one of those things the oncologist I haven't met yet will know more about.

    I learned from my PS today, while I was getting the drain pulled, that my BS had spoken to an oncologist and decided that I would require chemo. Kind of a sucky way to begin an appointment but I sort of knew that was coming anyway. Can't say I'm thrilled but at least it feels like a plan.

    He also said he wants to speed up my fills in order to have them finished before chemo starts. The plan, at this moment, seems to be chemo first, and then either further tissue removal or to excise that strip of skin during the exchange surgery. To that end, he will overfill the cancer side to give the BS skin to work with without compromising the reconstruction.

    I have no idea what my chemo plan might look like. I imagine though that there is a long road yet to walk. I guess the question of radiation will be answered a little further down the road. Follow-up hormone therapy is a given though.

    The things we're forced to learn...

    Thanks for listening!

    I wish you both well...

  • chrissyb
    chrissyb Member Posts: 16,818
    edited June 2011

    Nytemagic, have a look in the forum index and see if you can find a chemo thread for the month that you will be starting.  This will give you support from others going through what you are at the very same time and you may find that extremely helpful.  Your onc has quite a few to choose from and whatever he chooses, you will find information on it on these boards. 

    I like the way your PS is thinking and making provision for your re-excision so your recon will not be compromised.  On to the question of rads, it's not always given when you have had chemo but the final word on that belongs to your treating team.

    Love n hugs.  Chrissy

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