Taxotere is a nightmare

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  • Fighter_34
    Fighter_34 Member Posts: 834
    edited April 2011

    Meek so sorry to hear this. No I have never heard of this b-4. Perhaps the advil mixed w/ the chemo didn't work nicely together. Glad your better now. When you are down to your last two tx you will have everything down pack, but guess what you will be done then.Kiss

  • Anonymous
    Anonymous Member Posts: 1,376
    edited April 2011
    Meekone:  At round #1, had the same unbearable pain which sent me in fetal position too.  Presented to the ER coz thought I had either a bladder infection or UTI.  Told my onco that unless he gave me strong pain meds, I was not going for round #2.  Took the meds throughout the Napogen shots.  I'm now celebrating 1 year post chemo and feeling fine Smile
  • tracie23
    tracie23 Member Posts: 598
    edited April 2011

    Hi Meekone, I had to take oxycodone for the pain ... I ended up in the ER with fevers after my 1st dose and it ended up being a UTI I was in the hospital for 5 days.... But it all does get better and soon you will be done. 

  • bdavis
    bdavis Member Posts: 6,201
    edited April 2011

    Meekone

    I had a lot of headaches and body aches with TX 1 but the subsequent txs were much better.

    I take Decadrom for three days and I am sure it helps a lot... plus all teh premeds (Zofran, pepcid, decadron, benedryl)... and then 2 days after chemo I get Neulasta (which the first tx will for sure cause achiness as the bones expand) but its much better after first tx... 

    hang in there.

  • Linda-n3
    Linda-n3 Member Posts: 2,439
    edited April 2011

    Welcome, meekone! Sorry you found yourself here, but we are all willing to listen and share.  I had a lot of pain as well, did the curl-up-in-a-fetal-position thing for several days with each cycle, but that has indeed passed.  As they say, "just breathe!"  Not easy to do when you are in the middle of it, and don't be stoic - be sure to let your onc know and get some adequate pain relief! And if you are on oxycodone or any other opioid, be sure to start a stool softener earlier rather than later for constipation!!!

    Tracie, lago, fighter, luan, omaz, et al, thinking of you all tonight and sending good thoughts!

    I am participating in a yoga and cancer survivor study - had a good session tonight.

  • bdavis
    bdavis Member Posts: 6,201
    edited April 2011

    BTW... had my 5th of 6 treatments today... so only one more.PHEW!

  • lago
    lago Member Posts: 17,186
    edited April 2011

    n3ypb thanks for thinking of me. I'm at the easy part now. Went without scarf yesterday & today. Called up my hair dresser and he said come on over. Dyed my hair from the gray and the black (never had black hair before) to my old dye color. Not sure if it's too red but I do feel younger. The black/gray was actually pretty but I'm just not ready to be Jamie Lee

    http://topuspost.com/wp-content/uploads/2011/04/jame-lee-curtis.jpg

  • marjie
    marjie Member Posts: 1,134
    edited April 2011
    Lago - Hopefully you'll post a pic of your new hair/colour.  I seem to be going to grey and black as well and was figuring I would have to grow it quite a bit before getting it coloured.  LOL oh to have as much hair as Jamie-Lee!
  • Linda-n3
    Linda-n3 Member Posts: 2,439
    edited April 2011

    I have decided to go au natural on Easter - seems like a good date to aim for.  My hair is dark salt & pepper, with a reverse skunk thing going on, but I am so sick of the wigs.  I started with a longer wig, wore it from October to early March, got the usual spring itch for a new "do" so got a short & sassy wig on sale for $35, much less than I would have paid for cut & color.  Am thinking of going natural color for a while to see what it might be like - I have been in the auburn/red to blond color for over 20 years.  Am also thinking of keeping it short as it is a whole lot easier to deal with than my usual wild & crazy mane that won't do anything I want it to do.  But I also am not after that Jaimie Fonda look, either!  Wink (maybe if I was as tall and thin as she is I might be able to pull it off, but I am short and what they call "petite").  I did have a short meltdown when I was putting some things away and ran across the baggie with my old hair from before chemo.  Just a reminder.  But I am so grateful it is growing back and looking not too bad! Lago, I think you could actually pull of the Jaimie Fonda look, based on your photo, but I know what you mean about liking your old hair color and it making you feel younger. 

    Also, I found out that I can donate the wigs to a local hospital for women who cannot afford one and whose insurance does not cover them (mine does not - also mine does not cover any reconstruction for lumpectomy, regardless of deformity, only for mastectomy - but it does have fairly good drug coverage).

    Just another sleepless night here... heading back to bed soon for a nap before work

  • LisaGH
    LisaGH Member Posts: 242
    edited April 2011

    meekone- I had a terrible headache on round 1 of tch. it did not happen on rounds 2 and 3 (i have round 4 tomorrow). i did talk to my onc about if it came back what else i could take. he and i discussed meds i took for migraines pre chemo (i had them bad around perimenopause). Hope you feel better soon.

  • Omaz
    Omaz Member Posts: 5,497
    edited April 2011
    n3ypb - How are your eyes doing?  Any improvement?
  • hopefortomorrow
    hopefortomorrow Member Posts: 193
    edited April 2011

    I had trouble with headaches and they switched my anti-nausea drug. They said that could be causing the problem. It did help quite a bit. I am prone to headaches though. I had them really bad when I was on AC. On the TX I only had a few in the beginning.

  • lago
    lago Member Posts: 17,186
    edited April 2011

    I'll be posting my new hair color on the hair thread later today. Yes I can pull off the look. Even my hair dresser said he didn't think it looked bad. I look a lot younger than Jamie Lee IMO even after all this chemo. The grey makes me look as old as she looks. (She's only 2.5  years older than me.)

    The reason why I can pull it off (and Jamie Lee too) is not the thin tall thing. It's the long neck.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited April 2011
    n3ypb - thanks for thinking of me :) - I hear yoga is excellent and thank God for those doing the actual research - "Research has shown that yoga and other types of mind-body practices, incorporated into the standard of care, can help improve patient outcomes, particularly quality-of-life"
  • hopefortomorrow
    hopefortomorrow Member Posts: 193
    edited April 2011
    I looked up tea tree oil since we have been talking about nails here. I have been using it just because my Oncologist recommended it.

    Tea tree oil has beneficial medical properties when applied topically, including antiseptic, antibacterial, antifungal, and antiviral action,[2] and is also believed to have beneficial cosmetic properties.[3] Tea tree oil is usually used diluted, as reactions are common with pure tea tree oil, but it can also cause irritation for some people even when diluted. Tea tree oil is toxic when taken internally, and so should never be added to food or drinks.

    Tea tree oil has strong activity against Staphylococcus aureus, including MRSA.[4] When used at 5% concentration, it has not been shown to cause drug resistance; however, some resistance occurs at lower concentrations such as 0.5%.[5]

  • Linda-n3
    Linda-n3 Member Posts: 2,439
    edited April 2011

    omaz, eyes are not worse, not better.  Have only been on drops since Thursday night, so will give it a few more days.  I think I do so much computer work that it doesn't help either.

    lago, my hair was toward the red side which suits my personality, so I'm not sure how the salt/pepper is going to work for me, but have decided to give it a try. I'm looking forward to seeing your new color! What fun! I realized I don't have long enough hair to have the bangs that Jaimie Lee has quite yet...

    The yoga thing may be good, but I ended up with some aches & pains in my shoulders that I wasn't expecting - it is more demanding that appears on the surface! Guess I am going to build up some muscles sooner rather than later at this rate! Smile

    For the ladies who are in earlier stages of chemo, wishing you rest and freedom from pain tonight. 

  • lago
    lago Member Posts: 17,186
    edited April 2011

    I did post on the hair thread so if you click on the link I provided in my last post the after & before pictures are posted on that page. I'm glad I got rid of the salt & pepper. I can't believe how much new gray I got with chemo. I wonder if it goes back? I know the black should grow back brown eventually.

    To be honest I wish the new wrinkles from chemo would go away. I know that's not going to happen.

  • Omaz
    Omaz Member Posts: 5,497
    edited April 2011
    lago - You hair is lookin GOOD!
  • rcca
    rcca Member Posts: 59
    edited April 2011

    Meek, My onc blamed the Zofran for my migraine and prescribed something else. Only had the migraine after my first treatment.

  • Mimidi
    Mimidi Member Posts: 231
    edited May 2011

    I sure hope everyone is doing O. K.  I have my third abraxane treatment this Thursday.  5 more to Doing better since the taxotere was stopped.

  • Linda-n3
    Linda-n3 Member Posts: 2,439
    edited May 2011

    How is everyone doing?  I have had more of each day being good, still deteriorate when I am tired, but every day I have more energy to actually get my work DONE rather than dragging through it and not finishing.  Made major progress on the work pile today!

    Had a meltdown tonight when I was so very much wanting to go play the piano for just a few minutes, but finger sensations just unbearable with ANY type of tapping.  Cry  So I ate a handful of mini-Reese's peanut butter cups, a Klondike bar, and turned on the TV to find something else to focus on.  My PCP is thinking of sending me to a neurologist, and so I did a little search to see what might be out there... also ran across an article on damage that taxotere does to teeth!  Apparently damages both developing and mature cells of all dental cell types, but apparently is reversible (60 days after exposure in mice... don't have any idea what that translates to in humans, but maybe about the same??? I hope!)

    Morphological Classification of Dental Lesions Induced by Various Antitumor Drugs in Mice

    Hiroshi Satoh, Yasuo Uesugi, Takami Kawabata, Kazuhiko Mori, Fumitaka Fuj, Yoshinori Kashimoto, Tetsuyo Kajimuraand Kazuhisa Furuhama; Toxicol Pathol 2001 29: 292
    http://tpx.sagepub.com/content/29/3/292.full.pdf+html

    I know someone else on this thread has had problems with teeth, and this is the only article I found that was primary research.  I have an appointment with my dentist in a couple of weeks and will talk with her about this, and also have a friend who is on faculty at a dental school and have her looking into it as well.  My scientifically curious side is quite interested in this, but my emotional side and aversion to chewing food is just plain annoying.

    Have appointment for first surgery follow-up since Sept. with the NP; already got the results of mammogram & sonogram & PET scan: NO EVIDENCE CANCER!!! Laughing So seeing her is sort of a formality, I guess, plus the exam (I am having tough time with self-exams - sure hope the fingers get better soon!).

    Also, have figured out each time the fingernails grow out to the chemo line, that is when they are most likely to pull up, and they feel like little bamboo shoots underneath for a week or so, then ease up.  Looks like another month or two and they will be all grown out and I will quit whining about them!

    Keeping you all in lovingkindness,
    Linda

  • EmilyInOntario
    EmilyInOntario Member Posts: 626
    edited May 2011

    Just thought I'd post an update on my experience with taxotere 12 days after round 2 of taxotere...

    So far the fatigue is still bad...spend most of the time on the couch in between attempts to do dishes or laundry etc. Very frustrating. Also just feel generally unwell and have totally turned off bread and some other foods since so many things taste unpleasant. I had leg pain both round 1 and 2 for about 5 days and took oxycodone every 4 hours until that subsided. I also developed a bad wine red rash on the back of both hands which is sore and caused the skin to thicken and then peel badly. I THINK it is starting to clear a little. Also started with mild numbness in the tips of my toes about 4 days ago and losing my eyelashes. I have my last round of taxotere in 10 days and am wondering if I should ask for a slight reduction in dosage. The onco offered last time but I was concerned about doing anything that might reduce the effectivenessso I declined. Any thoughts on this?

  • EmilyInOntario
    EmilyInOntario Member Posts: 626
    edited May 2011

    Oh..I'll just add that my eyes water a great deal of the time which is so annoying...

  • bdavis
    bdavis Member Posts: 6,201
    edited May 2011

    yes,,, watery eyes is me too... in fact if I just walk, the breeze makes them water more... so I tend to not look straight ahead... I will say though that this has been intermittent since starting in January... I have it, then I don't... and my vision isn't as goo, but it was worse when I started TC and has improved (or I've gotten used to it)

  • marjie
    marjie Member Posts: 1,134
    edited May 2011
    EmilyinOntario - oh the watery eyes drove me nuts and I had a bleeding nose at the same time - very pretty!!  Dosage is based initially on your size and body weight then is adjusted as needed.  My first dose of taxotere was reduced by 20% because I did not handle my first 3 rounds of FEC very well.  My second does of taxotere was reduced again but not as much.  My onc assured me that the effectiveness of the treatment wasn't affected but if it got to that point, they would look at different drugs for treatment.
  • sandymess
    sandymess Member Posts: 299
    edited May 2011

    Yes, those watery, twitching eyes were SO annoying! My vision really went south too for a while, but I just came back from the eye doctor and it has returned to normal. So there is hope! ;-)



    I also got a rash after the 1st and second tx's. They started me on Benedryl and Pepcid and that solved the problem.

  • Mimidi
    Mimidi Member Posts: 231
    edited May 2011

    Emily with what you are saying about your hands you could be having an allegric reaction the the deliverying solution of the taxotere. This happened to me and I had to come off of taxotere. My oncologist was able to change me to abraxane when this happened. Only after my severe reactions would my insurance pay for the abraxane.

  • dragonfly1
    dragonfly1 Member Posts: 766
    edited May 2011
    Sandymess Just curious about how your vision changed. I've had four treatments with taxotere so far and my 5th will be next week. I have noticed that I don't see as well at night and I definitely have more trouble watching tv and in low light conditions. My vision was fine before chemo. Did your vision do the same thing and if so, how long did it take to go back to normal? I'm very encouraged to hear that it returned to normal by the way! 
  • sandymess
    sandymess Member Posts: 299
    edited May 2011
    dragonfly1: I have worn glasses for distance for many years, but I didn't need them for watching television, working on the computer, reading, etc. After I started on the taxotere/cytoxin, I had trouble reading--had to use my husband's +2.5s, and forget about reading the computer screen or seeing tv! The doctors said to give it some time before having my prescription changed, but I never had to. I only went to the eye doctor because I broke my sunglasses and needed a prescription to get a new pair. He said my eyes are back to where they were before chemo. I think it came back almost immediately after tx finished. Hope yours does the same!
  • EmilyInOntario
    EmilyInOntario Member Posts: 626
    edited May 2011

    Just checking in again. The rash on my hands is clearing up but the weakness in my legs is bothering me. I'm 18 days post chemo and this is my second round of taxotere.I find it hard to walk any small distance because of the weak legs. I'm also not "bouncing back" to sorta normal this round. I feel as tired as I did a week ago and am fearing another round of taxotere in 5 days when I feel so run down still. Anyone else experience this?

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