Xgeva vs Zometa?

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meima-Bev
meima-Bev Member Posts: 2,432

I just got home from my 45th Zometa infusion in my very poor veins in my hand..... 3 sticks, 2 nurses.  The nurses suggested I ask my Onc. to try Xgeva since it is a once a month injection in the arm.  It's still rather new and I wondered if anyone is on it and how are the se's, etc?  Coincidentaly I see my Onc. tomorrow and I want to have my questions ready.  Thanks for any input.     Meima

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  • jenn3
    jenn3 Member Posts: 3,316
    edited March 2011

    I just started Xgeva last week.  The shot can be taken in the arm or stomach.  I did the stomach and didn't even feel the needle.  As of today, I've had no SE's.  From what I understand Xgeva and Zometa do the same thing, except that Xgeva is easier on the kidneys.

    Give it a shot - get it, shot.............

  • Lynn1
    Lynn1 Member Posts: 2,141
    edited March 2011

    Jenn....shot...ah..ha ha! 

    I'm supposed to start Xgeva on Friday so I'm curious as well -- Jenn, glad you've had none so far!  Awesome!   I didn't have any se's much with the Zometa, so hopefully this will be similar.

  • Karen66
    Karen66 Member Posts: 31
    edited March 2011

    My Onc. has prescribed Xgeva but his business office keeps trying to get me to use Zometa.  Something about the money.....geez!  Talk about us not needing to deal with stress while we go through this crap, huh?  I'm not giving them an answer until I talk directly to my onc. this week.  I've heard Xgeva is so much better for your kidneys.  If you've been through chemo before, then your kidneys have already had a difficult time.  I'm still pushing for Xgeva.  Good Luck!

  • irish22
    irish22 Member Posts: 334
    edited March 2011

    I've had Xgeva twice now and have no side effects and it's just a quick shot in the upper arm for me at the end of my chemo. Like Jenn said it's easier on the kidneys (and since I work with renal failure patients I was excited about that). It's also supposed to have less side effects overall then zometa. I've never done zometa so I can't compare one to the other but the np at my clinic said all the other patients love it compared to zometa.

  • Jill45
    Jill45 Member Posts: 71
    edited March 2011

    I've had xgeva twice as well and no side effects. I also got the shot in the stomach and did not feel a thing. It is alot faster and easier that the Zometa IV.

  • Heidihill
    Heidihill Member Posts: 5,476
    edited March 2011

    Bumping for mollyart

  • cmhartley
    cmhartley Member Posts: 1,091
    edited March 2011

    Love it love it love it......Zometa?  hate it hate it hate it!!!!!!

    Enough said :)

    Cat

  • Marybetz
    Marybetz Member Posts: 202
    edited March 2011

    Is this just for HER- gals?

  • joaniji
    joaniji Member Posts: 733
    edited March 2011

    Hi Meima,

    I don't know how you put up with so many needle sticks! I am a wuss and can't stand the needles, so I had a chest port put in.  Have you thought about this? It was a minimally invasive procedure which had virtually no recovery time and has saved me so much stress and pain.  I am on Zometa so I can't really answer your question but I have a question for you - how often do you get Zometa?  If you have had 45 treatments of Zometa you may want to ask about spacing the treatments out a bit.  My onco. has mentioned to me that after 3 or so years of Zometa that I can maybe go to every two months instead of monthly treatment.  I hope that if you switch treatments that the process goes smoothly!

     Best, Joani 

  • mollyart
    mollyart Member Posts: 22
    edited March 2011

    Thank you for asking this question. It is so helpful to hear everyone's opinion. It is difficult to believe the drug manufacturer's claims, as they are promoting theirs as the "latest and greatest". I am pushing for my sister to take Xgeva.

  • meima-Bev
    meima-Bev Member Posts: 2,432
    edited March 2011

    Thank you all so much for your replies and good wishes.  Based on what all agree I will push for the Xgeva.  Joani, I have been getting Zometa for over 4 1/2 yrs and now am on an 8 week schedule.  Port hasn't been discussed as I am not on Chemo (Tamoxifen & Zometa).  When the time comes for Chemo, I will definitely get a port.  I did have Chemo my first time around with BC in 1992, but since I am 95% er+, have been doing ok with hormonals.  Best wishes to all,     Meima

  • dfleaman
    dfleaman Member Posts: 159
    edited March 2011

    I love the xgeva.  I do have pain for the 1st couple of days.  I get the shot in my hip becaue of lymphadema in both my arms.  It is so much better than being hooked up to IVs.  It used to take about 3 hours now it only takes about 1 hour depending on how long I have to wait to see the dr.  Dr. thinks it is great!   

  • cookie97
    cookie97 Member Posts: 908
    edited March 2011

    Wow ladies, I've never heard of this. I will so talk to my onc on Monday when I go for my Zometa infusion. I was never able to use my port as they had to remove it even before I started chemo, so all 9 of my chemo treatments were through my veins that are now too scarred for use. We have to creative everytime I get the Zometa.

    Thanks all for this thread and I'll let you know what he says on Monday.

    Peace and Love,

    Edie

  • meima-Bev
    meima-Bev Member Posts: 2,432
    edited March 2011

    Hello all, just a little update:  I saw Onc. yesterday and she agreed switching to Xgeva; said it is just as good as Zometa and if insurance balks she will let them know about the vein issues and should be no problem.  I hope this drug helps so many of us ladies who suffer with vein problems and makes getting our treatments a lot more tolerable.    Best wishes,     Meima

  • Lowrider54
    Lowrider54 Member Posts: 2,721
    edited March 2011

    meima...you are reading my mind girl...I haven't gotten my Aredia back since the tooth fun and I go the 15th of April and supposed to restart the infusions and I have been saying to myself ' what about this Xgeva?'. 

    It has the same SE's which I am already doing stuff for but - my treatment days could turn into 2 Faslodex shots in the butt and 1 shot of Xgeva in the arm or tummy - wow, save my viens for chemo - something that maybe could happen in the far off distant, distant, way far down the road...

    Thanks to everyone for your comments - it has sure helped another 'sitting on the fence' infusion bone strenghtener to ask for the Xgeva.

    Hugs all and Meima...your timing is excellent - I was actually going to post this same question today and then I saw yours...LowRider

  • Lynn1
    Lynn1 Member Posts: 2,141
    edited March 2011

    Finally! Just got a call from the onc's office. Everything has been approved and I will get my first Xgeva shot tomorrow afternoon.

    Here is the cool part....anyone starting Xgeva should ask about this:  the company that provides the Xgeva offes a "co-pay card".  I've never heard of that before, but they said I just had to fill out a little paperwork and the company will pay everything for me -- my only responsibility will be $25 per shot.  Woo hoo!!

  • meima-Bev
    meima-Bev Member Posts: 2,432
    edited April 2011

    That's great Lynn!!  Let us know how you make out.     Meima

  • hope10
    hope10 Member Posts: 58
    edited April 2011

    much better than zometa. I had my 4th shot today. the chemo nurses say to watch your calcium levels.  Side effects ---- it lowers your calcium. So it is important to take calium twice a day.

  • Lynn1
    Lynn1 Member Posts: 2,141
    edited April 2011

    Hi all....just a quick update.....got my 1st Xgeva shot on Friday, April 1st.  I didn't even have to ask about where -- she came out and asked me to roll up my sleeve....so in the arm it went.  My arm was a little sore that night and the next day, but not too bad...sorta like a flu shot.  Otherwise, NO se's at all!  This stuff is so much better than Zometa to me!  Now, just hope it helps the Femara do it's job!!

    Meima:  did you get your 1st shot yet?

  • meima-Bev
    meima-Bev Member Posts: 2,432
    edited April 2011

    Hi Lynn, I'm glad no se's from the Xgeva!!  I had just had my Zometa when we talked about the Xgeva so I won't get it till end of next month.  I will let you know how it goes.     Meima

  • lwd
    lwd Member Posts: 1,084
    edited April 2011

    Hi all,

    I'm happy my onc decided to switch me to Xgeva.  I'll have my first shot next Wed.  I feel better knowing it shouldn't be so hard on the kidneys, plus I'll be in and out in a jiff.  Glad to hear the SE's have been minimal.  I hadn't heard about the calcium issue.  I'll ask.

    Marybetz, it's not only for HER-.  It helps strengthen the bones and hopefully help stop the cancer from spreading.

    Lane 

  • Sweetanimo
    Sweetanimo Member Posts: 22
    edited April 2011

    I had my third shot last week and only slight nausea and tiredness a few hours later.  My private health insurance (I'm in the UK) will only pay for three more :-( then it's back on to Fosomax ... 

    Hopefully our equivalent of the FDA will approve it for bone mets use soon...

    Anne Marie

    xxx

  • DivineMrsM
    DivineMrsM Member Posts: 9,620
    edited April 2011

    Interesting.  I'm half way thru my 6 chemo treatments.  Last week I was discussing what was  going to happen after chemo with my onco.  She mentioned xgeva. Sounded like she, too, thinks its the better option that Zometa.  She did comment, tho, that it was often an insurance issue whether or not you get approved for it.  Yet it does sound like it may quickly become the standard of care for those with bone mets.  I am hoping when I get that far in treatment my insurance company will approve.  Anyone else have any insurance issues about getting it?

  • Lowrider54
    Lowrider54 Member Posts: 2,721
    edited April 2011

    Lynn...great! 

    Lane...you too

    meima...glad you will be

    and again, to you others that offered opinions to meima's post

    I called my onc's nurse yesterday to inquire - I have my appointment on the 15th and I would be getting the Aredia back - I didn't get a call back yesterday so I imagine they are looking into the insurance company's approval - they haven't denied anything yet. 

    So, more calcium?  I rarely remember to take the third one at night but now I have a med I have to take at night so 2 in the am and a third at night should do it? 

    TheDivineMrsM - Since I always get a call back the same day and didn't, I imagine it could be an insurance issue, I will let you know and like I said, they haven't denied anything in my treatment thus far. 

    Now the big question - how the hell do you pronounce it?????  Phonetically  - zeg va or exgee va?

    PS - Nurse just called, putting it through the insurance and she pronounced it 'ex gee va' - they have one other person on it at my treatment center and so far, he is doing just fine with no ill effects.  She did say that since I am doing so well with the Faslodex that is it likely it will long term use and the kinder to the kidney's is a good thing and it works better than the Zometa and the Aredia - not tremendously but the kidney kindness is a huge advantage.

  • meima-Bev
    meima-Bev Member Posts: 2,432
    edited April 2011

    My Onc. and two nurses @ infusion in hospital pronounced it ex gee va. Hope you get the insurance approval.  Let us know how you make out.     Meima

  • Lynn1
    Lynn1 Member Posts: 2,141
    edited April 2011

    Mine prounouced it the same way as meima did.   Ex-gee-va

    I do know that it took them 3 days to get it approved by my insurance, which seemed longer than usual, but they did finally approve it.  I hear it is insanely expensive....can't wait to see my bill!  :-\

  • Lowrider54
    Lowrider54 Member Posts: 2,721
    edited April 2011

    That was weird...all 3 posts went up at the same time...I was editing mine and you two were writing yours...let's hear it for ex Gee va!

  • donsuzbee
    donsuzbee Member Posts: 129
    edited April 2011

    I was put on the Xgeva in Feb so have had 2 treatments - both in the abdomen.  1st time no se's.  This last treatment I had bone pain worse than any time since I started treatment of Faslodex & Aredia in Feb 2010.  When I was on the Aredia, I only got 1/2 dose as I only have 1 kidney and I have Chronic Kidney Failure - not on dialysis yet.  I wondered if I had more of a reaction to the Xgeva getting a full dose than I did before with just getting 1/2 dose of the Aredia.  There is co-pay assistance from the drug company of Xgeva.  BUT not if you are on Medicare and that's me.  I don't know what else to think caused the excessive bone pain immediately after the treatment other than the Xgeva, but I see none of you gals have had SE's.  Although I do have arthritis issues somewhat.

    Keep me posted! 

  • lwd
    lwd Member Posts: 1,084
    edited April 2011

    I had my first Xgeva shot last week, in the back of the arm.  I was given the choice of my stomach or arm.  It wasn't bad, but a little more sting, and longer than I expected.  I guess I was thinking something like a flu shot.  NOT!  But, much easier than the Zometa infusion.  I, too, will be interested in finding out how much they are charging. 

    The nurses and onc said no one so far had complained of SE's after their first shot.  I may have been imagining it, but I did feel a little achey that first night.  Similar to Zometa.  But, maybe it was all in my cloudy mind.  And maybe no one wants to complain because they're so happy to switch.   

    Lane 

  • JeninMichigan
    JeninMichigan Member Posts: 2,974
    edited April 2011

    I asked my oncologist about switching today.  I am currently on Aredia and getting rid of the 1 1/2 hour infusion would be great.  She said she is not ready to switch especially if Aredia is working for me (which it is).  She said that the Xgeva works a little differently than Aredia and Zometa and she wants to save it in the event I become resistant to either.   She felt the side effects where roughly the same and only a mild improvement regarding the kidneys.  So for now, I am stuck with Aredia :-(

    Jennifer 

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