How many of you have family history?

No first degree cancer BUT multiple first cousins, all on my mother's side..breast and bladder cancer in cousin diagnosed before age 50, uterine cancer , now with mets also diagnosed before age 50, 2 males with bladder cancer.I have ALH and LCIS and Barretts esophogus.I have no idea what's going on in my father's side!

I tested neg for BRCA 1 & 2 despite having 8 cousins descended from grandmother's mother's family, all Slovakian, Ashkenazi Jewish who've had BC, four of them were tested and all were neg. for these known genes. Because of this I decided someone had to do the extended gene sequencing test (not covered by ins.) I did it and they found 2 mutations on the BRCA 2 gene but said that at this time they are not known in any databases to be harmful mutations, but that I should keep in touch with them in the future. I don't have any immediate relatives with BC (though Mom had lung cancer and Dad had leukemia and prostate cancer - both long term survivors by the way, YAY!) Also, my Mom took DES through the first trimester of her pregnancy with me, so could be environmental in my case and not genetic altogether. I just wanted to know, though, as I have a daughter. I guess we all want to know what caused this and we may not know, at least in our generation.

My family history

- maternal grandmother died from breast cancer at 61

- mother dx uterine cancer at 52, died at 56

- my younger sister dx ovarian cancer at 67

Hello Sunrisesunset,  How hard it must be to wait for information about this.  Cancer strikes many families, which makes it even more difficult. We know much more about the disease and we are more vulnerable to the emotions.  There is almost a kind of survivor's guilt.  I'm sorry you are going through this.  I hope you can hold on to the thought that this might not be serious, and that you are healthy.  Hoping for the best,  G.

Ugly family history--I'm a fourth generation breast cancer victim. My mother died at the ripe old age of 41 from breast cancer, my dad had a mastectomy at 71, maternal aunt, maternal first cousin, my youngest sister. I've been genetically tested twice--it was negative--so they just haven't found my mutant gene. I had stage 1 ER+ ductal carcinoma in 1998, lumpectomy, radiation, tamoxifen. In June I was diagnosed with triple negative, grade 3, stage 1b. Bilateral mastectomies a few weeks ago, chemo starts in the next few weeks.

Mother had breast cancer in 1999, still alive.  Her Sister died of colon cancer.  Her Father had prostate cancer.  His Brother died of leukemia and his Mother died of some kind of cancer.  None known of on my Father's side, but his Father died when he was five so very little is known.

I am also the first in my family.  After talking with the docs and finding out the percentage of patients that do not have a history, I was curious to know why they even bother to put that question on the medical history sheets!  It would have been more important for them to know that I am prone to staff infections after surgery and that was no where on the list.  When I went in for my port the general surgeon had to treat the infection from the mastectomy too!  He said it is very important to know if you have a history of staff so they give you the right antibiotics during surgery.

My father has had skin and prostate cancer, and lost a kidney last year with a pre-cancerous giant tumor on it.



My father's twin has had testicle, skin, bowel and bladder cancer.



My father's sister died from skin cancer in her eye.



Their mother died from bladder cancer, and everyone almost in her family died from some sort of cancer, including breast cancer in one of her sisters.



My mother had ovarian cancer 5 years ago.



My mother's sister had uterine, breast and lung cancer diagnosed 18 months ago. They were 3 separate cancers, but one of them metastasized 6 months ago, so she and I were doing taxotere at the same time.



My mother and aunt both test negative for BRCA. A few months after my DX, a study came out linking lobular breast cancer to prostate and/or testicle and/or bladder and/or skin and/or bowel cancer in the father. Since the twins have every cancer on that list, I figure that is the genetic link.

I always figured i would get cancer, given the family history, but I thought it would wait till my 60s like it has done for everyone else. Instead I got slammed while still in my 40s. Oh well!

My mom had breast cancer at age 62 -ductal, lcis and more,my aunt has breast cancer at 71, my greatgrandmother had bc....nothing else known. My other grandmother had bc in her 80/s.

I had every every brca test and they are all negative....

I am an Ashekanzi Jew as well.

I do worry about my daughter.