Interesting Read on Triple Negative

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LRM216
LRM216 Member Posts: 2,115
edited June 2014 in Triple-Negative Breast Cancer
Interesting Read on Triple Negative
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  • LRM216
    LRM216 Member Posts: 2,115
    edited February 2011

    Received this this morning from Google Alerts - hope the link works!

    http://www.medscape.com/viewarticle/736911

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  • chinablue
    chinablue Member Posts: 545
    edited February 2011

    I tried your link, but cannot access the article unless I am a member. What does the article say?

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  • Traci-----TripNeg
    Traci-----TripNeg Member Posts: 2,298
    edited February 2011

    It says a lot. I groaned at having to become a member, and I had to fib a little to get to it, but curiousity got the better of me. Very interesting reading. Here's just a tiny part: "Perhaps more important than identifying the basal-like subgroup within triple-negative breast cancers is the identification of subgroups of triple-negative disease that are sensitive to specific systemic therapy regimens. Several groups are currently developing biomarkers for the identification of the subgroup of triple-negative cancers with dysfunctional homologous recombination DNA repair, given that these tumors are likely to show an exquisite sensitivity to PARP inhibitors. Furthermore, other promising targets for subgroups of basal-like cancers have recently emerged (eg, FGFR2, TRAIL, antiangiogenic agents). Therefore, the question that is germane for the management of breast cancer patients is the identification of predictive biomarkers to substratify patients with triple-negative cancers into groups that can be managed more efficaciously with specific systemic therapies."

    Definitely worth reading. I would copy and paste the whole thing, but it's pretty long. 9 pages.

    Thanks LRM216, for posting.

    Traci

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  • LRM216
    LRM216 Member Posts: 2,115
    edited February 2011

    When I click on the link it opens right up for me so I thought it would for anyone else as well.  It is nine pages long, and relates all there is to say about triple neg and how they are finding there are many more subsets to triple neg - that so many of us triple negs are really very different, and that diagnostic treatments for all triple negs will be changing shortly in that they will be doing more cellular and molecular testing to diffentiate that particular subset, etc.  I found the descriptions of all the different types within subsets to be the most interesting, even reading about how some triple negs really don't have a bad prognosis at all.  Problem is - right now - for all of us already diagnosed - none of us really know what the heck we are.  Even those known to have the "basal like type" versus "triple negative" versus "non basal like" - there are so many subsets within each of those groups.  The article points out that every single triple neg is different - and each of our outcomes will be different.  I'd join it - I lied to get on it too - I found it worth reading.  I originally got it in this morning's google alert that I set up. 

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