Lobular Carcinoma in situ with stromal microinvasion

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AnkleEye
AnkleEye Member Posts: 12

Hello!  I finally got my pathology report yesterday.  Here's what it says:

Lobular Carcinoma in situ with stromal microinvasion

Lobular Hyperplasia (LN1-2)

Moderate stromal fibrosis

Microcalcifications identified

 My tumor is 0.4 cm and it's not even there anymore since apparently the stereotactic biopsy scooped it up.  I have ER + PR pos and Her-2 neu/neg

 I spoke to the breat cancer surgeon and she told me the plan was to first have an MRI of my breasts to make sure there are no other small tumors anywhere.  Apparently lobular cancer does not show up on a mammogram so for the rest of my life I would have to have mammograms and MRIs.

 If there is nothing else on the MRI, then I would have a biopsy of the area (it's at 11:00 on left breast) to make sure there are clear margins and then radiation followed by Tamaxafen.  If there are more tumors then possibly double MX.

 What I want to know is:  Does this sound good?  Has anyone else had this?  Anything I should know.   Thank you, dear ones.

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  • leaf
    leaf Member Posts: 8,188
    edited August 2010

     Microinvasion with LCIS seems unusual and ill-defined.  So I don't think they have good data on it.   Microinvasion, of course, would be smaller than macroinvasion, if that's a proper term.

    In this 1998 abstract Lobular carcinoma in situ is not known to progress to microinvasive disease. Although this feature is rare, the current understanding that lobular carcinoma in situ is a marker needs to be revised. http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1096-9098(199801)67:1<41::AID-JSO9>3.0.CO;2-M/abstract

    MICB was ductal in 18 patients, including one tubular carcinoma, and was lobular in three patients. ... Eleven patients underwent mastectomy, nine received radiation therapy, one received chemotherapy, and two underwent lumpectomy only. Median follow up was 28 months (range, 18–63 months). One patient had a chest wall recurrence of infiltrating duct carcinoma and another recurred with duct carcinoma in situ.

    “Microinvasion” has been a contentious term ever since it was coined. In squamous cell carcinoma of the uterine cervix, for which the term is well established for more than a half century, the microinvasive foci vary from 3 to 5 mm depending on the definition used. 26 The size controversy is worse in the breast, for which the term was introduced relatively recently. 8 The definition of microinvasive carcinoma of the breast (MICB) has varied from as vague as “DCIS [ductal carcinoma in situ] with evidence of stromal invasion,”18 “focal microinvasion . . . in one or several ducts,”12 “microscopic focus of malignant cells invading beyond the basement membrane,”25 “not invading more than 10% of the surface of surface of histologic section,”15,24 to as specific as focus of invasion measuring ≤1 mm 2,4,8,21 and 2 mm, 10,20 as summarized in an excellent commentary by Schnitt. 16 Thus, the extent of invasion in MICB has varied from one to several millimeters in the literature, making comparison of clinical data, and treatment recommendations, difficult. To still this nosologic mayhem, the Union Internationale Contra Cancer (UICC) introduced a new TNM stage, T1 mic, in 1996 and defined it as “microinvasion 0.1 cm or less in greatest dimension.”5 Since then, this is the first attempt to study the clinicopathologic profile of T1 mic tumors that adhere strictly to the most recent TNM guidelines by using an ocular micrometer to measure and a sensitive double immunoenzyme-labeling technique to evaluate equivocal foci of invasion. 13 http://journals.lww.com/ajsp/Abstract/2000/03000/Microinvasive_Carcinoma__T1mic__of_the_Breast_.12.aspx

    You may want to get 2nd opinions on both your pathology report and 2nd opinions on your medical care, if you have any doubts.

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