Mother Diagnosed T1a
Comments
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Short background: Mother is 72, her health is good, but in the last 3 years she has had hip replacement surgery, knee replacement surgery and spinal fusion (yep, all in a three year span).
Mamogram showed a small spot -> biopsy -> positive for DCIS -> 1st lumpectomy, no clean margins, DCIS also "numerous microscopic foci of invasion" largest focus 4.0mm.-no positive lymph nodes -> second lumpectomy -> still questionable margin (less than 1mm at deep margin), other margins are 2mm.
Also important, my father passed away last year with metastatic melanoma, so my mother is understandly doubly concerned.
Also important, I (her son) lives in a different state.
Today, she met with her oncologist, who diagnosed her stage as T1a.
He is currently recommending (1) meeting with radiation oncologist to see if additional surgery is necessary of if radiation may get the "problematic margin" area. (2) chemotherapy and then (3) radiation.
He also provided her with a "shared decision making" sheet showing risk analysis with various therapies. It is difficult to understand, but it says that 3 out of 100 women are "alive and without cancer because of therapy [chemo] and the other report states taht 1 out of 100 are alive because of therapy.
With her age, I am concerned about the effect of chemo and long term effect on her well-being. From the chart her oncologist provided, it appears that chemo helped 1 out of 100 people (over the "no additional therapy" category). If this is so, a 1% benefit doesn't seem "worth" the side-effects.
Her surgeon wants a third bite at the apple to clean up the margins. (so the doctors are already differing in their opinions)
So, with that said, is chemo a normal recommendation for a 72 year old woman with T1a? What type of chemo is recommended?
What other types of things should she consider? My knee-jerk reaction is to do everything, mastetomy, chemo and radiation. But, then again I am 40, not 72. I really want to get a decent protocol together than will not impact her quality of life.
Any insight would be greatly appreciated!
Thanks
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Your poor mother has been put through the ringer. My condolences on the death of your father. Your plate is quite full.
I was also diagnosed as T1a. I had dcis and Idc in one breast, with the idc 95% contained. I still opted for a mastectomy. I got clear margins, no node involvement. Because the tumors were so tiny, (less than 1mm total), I did not qualify for chemo. Rads, in my case, were not necessary. I am ER/Pr+, Her2+. I did ask my forner onc. as well as my present one, and both of them said that the side effects of chemo outweighed the benefits of chemo. There wasn't going to be that much difference, so neither one of them offered it. I am on Femara, and have been for the past 4 years. So far so good (I find out for certain tomorrow with visit to onc. to go over labs.)
I really don't know what I would do if it were my mother. I'm like you...the first reaction is to go after it with full guns. Maybe a second opinion here is warranted. What does your mother want? As to types of chemo, I don't know. But, one thing I woudl consider is quality of life. You might post over on the "older ladies" thread. There could be someone who will give you some insight there as to their experience. Someone should be along shortly.
Here's hoping you quickly find the answers you seek.
Jennifer -
Thanks for the response.
I just found out today, she is HER2 positive (3+). She is ER/PR negative. Her KI-67 is "borderline" at 15%.
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So sorry about your mother. But it sounds like her diagnosis is very positive as far as breast cancer is concerned. I too had a small her2+ tumor. Mine was 5 mm. Doctors were on the fence with regard to chemo, but since I was only 40 and had 3 small kids I went ahead. I can tell you that after having been through it, I would not recommend your mother have chemo for such a small tumor. Especially if the benefit is only a few percentage points on survival. Good luck with your decision. Noelle.
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random987 - I am sorry to hear your Mum has been through so much in such as short time and I totally I agree her quality of life is very important when considering treatment options. I was 52 at dx and was T1c. I had mastectomy (glad I decided on the mx as they found LCIS outside the ILC which could have been missed with a lumpectomy) which gave wide clear margins and had clear nodes so no rads and had no chemo (onc said it would only give me a 1% absolute benefit and did not recommend it because it would do more harm than good - just what her onc said). Because your Mum has already had two unsuccessful lumpectomies (there is no guarantee that she would get clear margins a third time either) rather than another re excision I would suggest she considers a mastectomy which should mean no more surgeries and would hopefully mean no radiation treatment (which can be hard on the body) if her nodes and margins are clear. As she is ER/PR negative and HER2+ Herceptin could be offered and that is probably worth agreeing to as it doesn't seem to be as hard on the body as other chemo drugs are.
Best wishes as you work your way through this minefield of options and decisions. If I can be of any further help please feel free to Private message me.
Rae
Rae
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Random--I don't think there is a normal course of treatment for older women. The latest NCCN guidelines recommend consideration of individual circumstances for patients 60 and older.I was 66 when diagnosed, and since chemo offered me a 0% benefit, I wasn't in the mood to try it. A 1% benefit doesn't seem much better. The odds are strongly aginst your mom being that lucky, hypothetical 1 in 100 who survives. A more likely result would be that 5 or 6 women would benefit to some extent from chemo, but would not have a complete response.
Your mother's tumor type does appear more likely to benefit from chemo than mine, but at best she might get only a partial response. You need to find out what kind of chemo is proposed. Some have harsher side effects than others, but chemo should never be undertaken lightly, because it can be temporarily and, in rare cases, permanently debilitating. You say your mom's health is good, but how strong are her heart and blood profile? The white blood count takes a beating from chemo + radiation.
Does your mom have a support network to help her out when you're not around? You are right in thinking that chemo might be difficult for her to manage alone.
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