Has anyone had IVF or other fertility treatment?
All the research I've found says that there's no link between IVF and a later breast cancer diagnosis... but I'm wondering if the flood of drugs/hormones has an effect that just hasn't been discovered yet. I hope I'm wrong, since I may have to do some type of fertility treatment in order to have a baby... but I will NOT do it if there's a chance it will increase my chance of a recurrence.
Have any of you had fertility treatments in the past? Do you think there's any connection or is it a random coincidence? Were you able to find any specific research about the two (either a link or lack thereof)? Thanks in advance... I'm so eager to become a Mommy but obviously don't want to do something that will jeapordize my ability to be there for my future child as he/she grows up!
Comments
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I must say I'm so relieved no one has chimed in with a horror story... because I got the all-clear from my surgeon today to be able to try for a baby (I have to wait 3 weeks for a mammo to make sure no new microcalcifications are forming but then my doctor is "letting" me try for a baby)!! Not sure if I'll go the IVF route, but will probably need injectables (gonadatropins)... ack!!!
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I went the IVF (just freezing embryos so far( route and just started chemo. THey did the whole thing right after my surgery and then chemo followed shortly. Since they did it in such a short time frame, the hormones they gave me should not have really interfered. We have to wait a couple years to see if we need to complete the IVF route though!
Hope taht helps! Best thing to do is talk to an IVF doctor!
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i did ivf before diganosis and hope to do it again if my periods return, there is a ovarian camcer risk but it is quite small, as they force your ovaries to become over active to produce many follicles to maturity instead of the one in a natural cycle. there are many follicles produced every month but there is only one (two in famile twining) that continues to grow and develop the egg until the body releases lh signalling the follicle to burst, the corpus liethuem then produces progesterone to thicken the womb lining to get it ready for implantation and usually 10 days after ovulation the hormones start to drop and the womb lining is shed circa 14 days after ovulation, starting the next period which is day 1 then on day 3 you should get your fsh level tested, low is good and an indication of a good reserve, anything below 10 is good, 10 - 12 not great and after that difficult to stimulate for ivf purposes. there are other tests such as ultrasound of the ovaries and amh testing. but the fsh is a good place to start.
best of luck with it, the injections are the easy part of ivf, its the rollercoaster of emotions that are hard, some days hope and other days despair, each step on it is very difficult and only 1 in 3 sucesses and lots and lots of money spent on a dream that we still share. the young survival colation have a thread on babies after cancer that may give insight, also a very good ivf website is www.rollercoaster.ie fertility issues thread and donor conception thread. i had the breast cancer before the ivf but did not know it, they thought it was a fibrodemna , so it did not cause me to get cancer.
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I had 1 IVF cycle before my diagnosis, but had about 6 cycles of hormone manipulation. I go back and forth with the idea that it caused my cancer, but ultimately I think the answer is no. First of all, cancer does not generally develop in 6 months to a year. I was HER2+ so that does make it go quicker, but still it seems odd. I didn't have to do chemo, but met with a couple of oncs who said I should continue with my fertility plans as soon as I want to. One of whom made it pretty clear that my age (35) is a bigger factor to my fertilily than my cancer. I am ER-, which I realize is good and bad, but good in the regard of fertility/pregnancy. Not a single doctor I met with discouraged me in any way about continuing. That being said, I'm scared to death of it. I'm just a few months out from my surgery and I am not ready to face pregnancy just yet. I've been dealing with that for over 3 years with 2 miscarriages in between and I don't know that I'm ready to handle that emotional roller coaster yet. Hope was exactly right that the emotional part of IVF is by far the hardest part.
Good luck to you. I hope it works the first time and you get exactly what you want. I know there are tons of women who go on to have babies after BC. I don't know how they get past their fears. Maybe they don't. I wish you the best!
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Thanks... hope2, I've been through all the fertility testing (FSH and about 28 other tests -- my FSH was 6 and I passed the CCCT; apparently I'm a "good responder")... I guess I was really asking more about whether anyone has heard any theories that IVF and the associated meds etc. lead to a higher risk of breast cancer (or in our case, recurrence). I know the current claim is that there is no correlation... but I'm no dummy, I know that often a link is often not recognized or established right away.
lmnop35, I know what you mean about the emotional roller coaster... I've had four late-first-trimester miscarriages plus a very early loss (chemical)... I'm not looking forward to dealing with that, but I'm 39 now and can't afford to wait any more!
Thank you for the well wishes. I guess even if I knew for sure that IVF can cause a higher risk of recurrence, I want a baby so badly that that's a risk I'm willing to take. It means I will have to be especially vigilant in monitoring and in taking care of my health. Thanks again for the replies.
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I had fertility treatment 18 years ago. I got breast cancer 6 months ago. I feel pretty confident that the two were not related. I have 16 and 17 year old boys. We were married for 13 years with no children, and no birth control. I went to a specialist in Atlanta, went through all the tests, then did the meds, and had our oldest son. After that, surprise, along comes his brother with no fertility meds at all. Best of luck to you!
Susie
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Susie,
that is lovely, what a nice suprise to get, the cancer is a bugger but i dont think that it is related to the ivf considering there are so many that get breast cancer that have never had ivf. the hormone recipent nature of the cancer is a worry but your oncoligist in general errs on the side of caution so would tell you not to go ahead if they thought there was anything remaining. Do ye not have to go through counselling before embarking on the baby making route as we were told we had to go for it to discuss things like what if i am not around to bring uo the child etc.
but personally i dont think they can advise you on one side to live your life as normal without undue worry but be vigilant and yet on the other side advise you not to have children as that is really living life as if it will come back and claim you.
mayby i am for the birds but i really want the chance to be a mammy.
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I just wanted at add another reassurance that in my case IVF did not cause my BC. I don't know what did, but I don't think it was IVF. I had IVF10 years before I was dx'd with BC. In my case, I had several miscarriages, an ectopic pg. Then we went to our fertility specialist but by then I was already 34. We should have gone earlier. IVF did not work for us, but we adopted our beautiful son after that and he is a blessing. For me, IVF was more rough emotionally (and financially!) than physically. As an older mom with bc and an 8 yo son, I say you should follow your heart. Children keep you young!
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I have just started IVF, before I begin neoadjvant chemo. I have discussed IVF and all the drugs and hormones involved, with my Onc. & BS, and they both gave me the go ahead. Because they will be giving Letrozole to help keep estrogen levels low.
I am very excited that I may have a chance at getting pregnant after my treatments are done! It's definately something positive to look forward to!
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I may be too late to chime in here, but here is my 2cents. I had twins thru IVF treatment 3.5 years ago, which means I had all the injections about 4 years ago...and I do believe there is some connection. They say that if you wait till later in life to have children, that increases your risks of developing BC. I was 36 when I gave birth.
When I put everything together, it makes some sort of sense. My age when I had the girls, the hormones I was taking for so long and then the additional hormones naturally produced from having twins can all be a factor in this.
This is just my opinion. but I did discuss this with my PCP and BS and they both agree that although there is no confirmed facts on this matter, they agree this could be a contributing factor. But I have to say, I wouldn't change any of it...my girls are my reason for living at this time.
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I had IUI (medicated) 6 times and 6 IVFs. I used lots of meds. My last IVF (trying for #2) was June of 09 and I was diagnosed with BC in aug 09. Interestingly, I had ER/PR- breast cancer. My doctors say there is no link, but of course I wonder. They say it is more likely that my pregnancy accelerated the cancer growth. My daughter was 18 months old when I was diagnosed.
Even if the fertility meds caused my breast cancer I am not sorry I did it. My daughter is the best thing in my life.
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MaryEllen, thank you so much for weighing in! My infertility specialist is not going to allow me to do IVF because she claims there's a higher risk of breast cancer.
My initial response is... I DON'T CARE. Nothing is more important to me than having a child. Your last two sentences completely sum it up for me. It's a risk I'm willing to take. Thank you again for weighing in.
edited to add: I just went to your blog... what a precious darling your baby girl is! And you look like you're 25!! Thanks again for weighing in with your story... btw, you're probably already familiar with this, but I only just heard about micro-IVF (or something like that) where they do minimal stimulation. Apparently they developed it for breast cancer survivors... the levels of drugs/hormones are just a fraction of what IVF normally floods you with. If you still want that baby #2, maybe that could be an option (and I will be looking into it as well). Best of everything to you and your precious daughter!
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Hi girls. I hate to be the one to throw in bad news, but I definitely think my fertility treatments played a role in me getting breast cancer. I also have a blog and other girls have contacted me saying they think fertility drugs played a role in their cancers too. If the fertility drugs weren't directly responsible for the cancer, then I definitely think they helped fuel the growth and make it spread (lymph nodes positive at diagnosis). I never did IVF but did several rounds (maybe 6) of Prometrium and Clomid, following about 12 years on the pill. I was diagnosed with borderline stage 3 HER2+ ER+ IDC last March right after a miscarriage. But I do have good news. It may not be for everybody, but I will tell you adoption has fulfilled me 100% and I couldn't be more happier. We adopted a baby boy in November (he's 10 months now) after my favorable pathology results after chemo and surgery. He is the cutest sweetest little scrumptious and looking back, I truly believe the fertility drugs caused the cancer, but in the end the cancer led us to adoption and eventually our son, so I guess they worked but in an indirect way. Here's my blog for more info: www.daniellemurray.wordpress.com Hope it helps! And no matter what you decide, I wish you the best!
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But, I do agree with MaryEllen, they are definitely worth it no matter what you decide, as long as you go a safe route and use one of the methods with lower estrogen like someone mentions here and monitor yourself. I am just biased because adoption gave us such a wonderful little boy.
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Danielle, thank you for weighing in... my hunch is that you're right... so I definitely won't be doing IVF while I have DCIS cells still in me. Danielle, your sweet boy is as adorable as can be... he is indeed scrumptious! I have only skimmed your blog so far but am curious to find more about what agency you used/what channels to adopt your son.
My infertility specialist had planned to do a Femara cycle for me this month. after having me on Metformin for three months. (For many women, Femara can work as a fertility treatment, not just a breast cancer prevention treatment, but it's taken on five days in the beginning of a cycle, rather than daily.)
But, now that I've found out I still have DCIS, I know she won't prescribe Femara. So, I've come up with a scheme. There are certain natural supplements (DIM, IC3, etc.) that have a similar estrogen-suppressing effect to Femara. So, this cycle, I took IC3 from CD3 to CD7 of my cycle... in hopes that it might have a similar effect on fertility (the estrogen-suppression phase causes the body to boost its LH and FSH, causing a stronger ovulation and healthier egg).
It's a kooky theory, but I don't see why it wouldn't work... we shall see if my theory holds true. In any case, doing it isn't flooding my body with artificial hormones, so hopefully I'm not doing any harm even if it doesn't result in pregnancy.
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We used an adoption "consultant" called A Step Ahead. We had to pay $2,500 extra but they have connections with like 30 different "agencies" so instead of finding and signing up with one agency, paying them a big amount of money up front and then waiting usually a year for a baby, we signed up with the consultant and didn't have to pay anything (other than the $2,500 and home study fees) until we were "matched", and then we paid the agency fees to the agency we got matched with a baby through. It went really really fast for us and doesn't usually happen in 3 weeks but it is supposed to be faster because you have exposure to so many more birthmothers. We also got a baby so fast because his original adoptive parents fell through last minute and we submitted our profile and the birthmother picked us. It was such a fun process and so fulfilling. My sister (26) had a baby in Feb and my other sister (30) is due next month. I look at their babies and couldn't imagine loving Aidan anymore than they love their biological babies. And I didn't have to gain any weight!
Good luck with all your fertility stuff though and let me know if you have any more questions about adoption! -
Wow... I hadn't heard of them so THANK YOU for telling me about them! So happy everything worked out so well for you and your sweet Aidan!
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I'd like to think there is no correlation, but I can't help but "go there" in my head. The older maternal age (34), 12+ years on the pill for me too, 6 cycles of chlomid, 2 IVF cycles, and 2 frozen embryo cycles ... then a hysterectomy and 10 years of HRT. Even though my BC is ER-/PR-, they yanked me off that estrogen SOOOO fast. I love my kids to pieces and wouldn't change my past, but if I were starting on that path again I think I would more strongly consider adoption. Just my two cents. Good luck to you though ... whatever path you choose will be YOUR path. {{hugs}}
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In case anyone is interested you may still be able to have a baby that is genetically yours without the pregnancy. I am considering surrogacy for #2. They use almost no estrogen, sometimes tamoxifen for IVF stim. NYU is a pioneer in breast cancer IVF. You may be able to use your own eggs and husbands sperm. The total cost is similar to adoption. One intersting site to check out is surromomsonline.com.
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Wow, MaryEllen, that is a very interesting option (I haad thought about that but didn't know what the first step would be in such a thing). Thanks for mentioning that and the surrogate site.
BTW - I'm trying to find that forum for women who went on to concieve and have a baby after cancer. I thought it was fertilehope.com but that's not it. Could anyone remind me what that site is?
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Unfortunately, I would have to say that I definitely believe my IVF and FET was a direct cause of my breast cancer. My IVF was done in January of 2003. I conceived and delivered a healthy baby girl at 36 weeks. In February of 2006 I did a FET. My BC dx was in May of 2006. I was 35 y/o. My FET didn't work.
I have three friends that have also done IVF and now have breast cancer. Elizabeth Edwards, another one. I am sure there are many, many more of us out there. In fact, I am so certain of a correlation, that I have contacted an attorney in NYC to discuss the potenial for a lawsuit against the drug manufacturers. Think about the huge drop in BC rates after it was released that Premarin and Prempro can cause it. Docs started taking their patients off it and boom...BC rates dropped dramatically. Premarin and Prempro are hormone combo meds...estrogen and a type of progesterone. The exact drugs that are used in IVF.
Now, having said all that I can definitely say I don't regret doing IVF, nor would I have chosen not to do it had I known the risks. I needed to have a family to feel whole, and now I do. However, we should be told there are risks so that women that have a strong family history of BC can chose a different option to have their family. So that we can be more proactive with pursuing a baseline mammogram and have them done every 6 months during infertility treatment. Fertility docs should just do a mammo as a prerequisite to the treatment process.
Hope that doesn't upset anyone, but for me...I am convinced. Good luck to all of you wonderful women in pursuit of your dreams and to be living with NED!!
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Oh I hate this. I was 7 months pregnant with my IVF baby when I found my BC. My sister-in-law knows 2 other women who did IVF and they too both have/had the C word. One had BC and the other another form of C. To top it all off.. all 3 of us went to the SAME fertility clinic and saw the same doctor!!!!

I too have no regrets having been through IVF and having been blessed with a son. We had a daughter who was 9 at the time and had tried to have another child for so long.
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My doctors said my fertility treatments had nothing to do with my BC but I find that hard to believe. I have a friend who works at an alternative treatment cancer center and she said most of the women there with BC have done fertility treatments.
I doubt they will ever do a study to prove it. Fertility treatments are a huge business.
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Bump
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I had my daugther through IVF in 2007 first cycle and had another 2 more rounds of IVF trying for baby #2 (1 fresh cycle and another FET) in 2010 and 2011. My diagnosis was in Jan 2012...I have considered if it has been IVF and concluded there are multiple factors :
- Late first pregnancy at 37
- Work stress
- Having young kids at a later age will mean lack of adequate rest physically
- family history with mom as BC survivor
- Lack of me time to heal mentally and physically
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I got all sorts of tests, was on clomid for 2 max dose was going to start IUI but got pregnant naturally. That was a little over 2 years ago. I am 38 and was diagnosed in January. I met met with my oncologist yesterday and no chemo yeah! But 30 rounds of radiation. I asked her about having another child and she told me she strongly does not suggest that I get pregnant agin because I am estrogen positive type. Have any of you ladies been told to definitely not get pregnant by your oncologist???? I am so confused still I think with information overload in the last month...I just feel like it is extreme???
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The latest research suggests that pregnancy does not increase the risk of recurrence. During pregnancy estrogen levels go up, it is true, but so do progesterone levels. Having a child and breast feeding is protective against getting BC in the first place, so it stands to reason (IMO) that having a child afterwards would not increase your risk.
My oncologist knew from the first time I saw him that I wanted to have a child. He respected my choice to do fertility preservation before chemo, and my choice not to take hormonal therapy after chemo and radiation. My son is 6 months old and my recent mammogram and ultrasound (3 years after diagnosis and surgery) was clear.
We will always have a higher risk of getting BC again than girls who have never had it. But there is no evidence that pregnancy will increase our risk. There are oncologists who understand we are people who want happy lives, not just bodies which have had cancer cells removed. That's the kind of oncologist you want!!
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Thank you sakura73 for your response! I was thinking about it all day yesterday and it really put me in a bad place! I am lucky in that I do not have to have chemo my onco level came back at 10 so I am starting 30 rounds of radiation therapy this week, so my eggs will not be the issue thank goodness This does show there is more of an option out there. I also thought about making a consult appt with my ob/gyn this week because I have gone to her for years and she knows me better than the new oncologist who has seen me twice. I have had all reports sent to her during this time since she knows me and my history. Thanks again!
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I also did IVF after surgery and before chemo. I am actually having my retrieval tomorrow so fingers crossed!
All my docs were in agreement that it was OK for me to do IVF, especially since I was starting chemo right after. I also took Femara so that my estrogen levels did not get out of control.
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roadwarrior - How did your retrieval go? I just had retrieval done hoping to freeze embryos before chemo. Unfortunately the eggs they retrieved were immature and although 2 matured in the lab, none fertilized.
Hope things went better for you!!
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