What S/E can I expect from Taxotere?

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undecided8
undecided8 Member Posts: 194

This is my 2nd go around with cancer and chemo. I'm starting herceptin/Taxotere this coming Wednesday. I was wondering if the s/e are similiar to Taxol? I had Taxol/herceptin last time and did pretty good on it without any harsh side affects. Has anyone else did just herceptin/Taxotere before? Thanks!

Suzanne E.

Comments

  • noellech
    noellech Member Posts: 86
    edited March 2010

    I would guess they would be almost the same, since they are related drugs. I had a hard time with taxotere. I was very allergic and had to take alot more steroids than most. I also had alot of nail damage with taxotere with lots of pooled blood and black spots on my nails. They all grew out eventually and they were tender but did not hurt. I think some people get pretty achy muscles from the taxotere. Hope it goes as well for you this time! Good luck, Noelle

  • robyn33
    robyn33 Member Posts: 99
    edited March 2010

    I had 6 rounds of TCH ending in Oct 2008.  I tolerated the drugs okay at the time.  But, I hate to report that my hair did not grow back--very, very, fine and terribly thin on top and crown.  Please be aware that approx. 6 percent of recipients have this side effect.

  • ElaineD
    ElaineD Member Posts: 2,265
    edited March 2010

    Try not to expect any-you might be pleasantly surprised! Despite it's repuation I managed just fine-lost my hair, but wasn't bothered about that. I honestly think that if you believe you will cope, you'll possibly manage ok. "Expect" to have side effects, and you very well may do.Good luck.

  • chainsawz
    chainsawz Member Posts: 3,473
    edited March 2010

    I had 6 rounds of TCH (taxoterrible, carboplatin, herceptin) in 2008 and my SE were similar to those of my worst day of pregnancy morning sickness.  I had aches, but I think that was caused by the neulasta shot I got the next day.  I did lose every single hair on my body by my 5th treatment.  It is definitely doable, just be very vocal about any SE you are experiencing with your onc...they are there to help alleviate those for you!  I think each person has a different reaction to the chemo so you won't know until you get there.  I had carboplatin mixed in mine, so your combo may not be as harsh?!  I did notice the first 3 or 4 treatments were easy....5 and 6 were very hard for me, but I go thru it and I didn't throw up once....yay!!! 

  • Boo307
    Boo307 Member Posts: 222
    edited March 2010

    undecided,

    I took TCH, but it was Taxotere, Cytoxin, and Herceptin.   I had a couple days following the infusion when I just wanted to sleep through it and then I was OK.  I was on a three week schedule and by the second week I was feeling better and on the third week I felt great!  I couldn't believe it.  Can't say what side effects were from the Taxotere and what was from the Cytoxin but overall it was manageable.  I would think just the Taxotere and Herceptin wouldn't be half bad.

    I made a point to walk just about every day.  I'd walk an hour when I felt good and just to the end of the driveway when I didn't.  I found the walking eliminated the Newlasta discomfort, so was obsessive about walking the day of treatment and for the next two or three days until the symptoms laid me low.

    I had some fluid retention, nail changes, and lost my hair, but it came in thicker than ever before.  Your anti-nausea plan should eliminate the chance of nausea or vomiting. And I almost forgot, Taxotere is excreted through the digestive system.  I found a squeeze bottle of warm water and a dap of vaseline took care of the irritation. 

    This may be helpful, it is a link to the Taxotere website and lists the side effects. http://www.taxotere.com/consumer/taxotere_treatment/side_effects.aspx

    Below are some of the side effects that are associated with Taxotere® chemotherapy treatment. Your experience with side effects will depend on factors like your Taxotere® dose, schedule, and your body's response to the treatment.

    Best wishes and I will be thinking of you. Boo

  • CoolBreeze
    CoolBreeze Member Posts: 4,668
    edited March 2010

    I did both carbo/taxotere and carbot/taxol.

     Taxotere, for me, was easier than Taxol.  However, neither were too bad.  Fatigue and achiness are worse with Taxol - neuropathy was worse with taxotere.

    I *think* my last one is tomorrow!  I hope!  You'd think I'd know but chemo-brain got me!

  • Beach
    Beach Member Posts: 127
    edited March 2010

    Sorry to report that Taxoterrible was very tough on me.  I've never been allergic to anything, but now "Taxotere" is on the list.  My tx plan was supposed to be 3 x FEC, 3 x Taxotere + Herceptin for the year.  FEC was a walk in the park compared to Taxotere, which had to be stopped after my 2nd tx.  Herceptin continued and all has been okay with that.....3 more to go!! 

    It's important to remember though that everyone reacts differently to chemo and therefore, has different side effects.  Many, many people do okay on Taxotere, and what I experienced was considered fairly rare as per my onc.  I did write a thread called "Taxotere - Beware" last June/July if you want more info.

    Best wishes and hugs ((( ))),

    Sandy

  • MTB42
    MTB42 Member Posts: 10
    edited March 2010

    I finished four rounds of taxotere, cytoxan and herceptin December 2009.  The herceptin continues along with Femara.  I did well with side effects.  A bit of nausea and fatigue for a few days after chemo and a real aversion to food.  Lost pretty much all taste, although some of it has returned.  My hair thinned tremendously but is now growing back in.  Still have a bit of neuropathy in my toes and my big toenails are loose - but, honestly, nothing was really terrible.  I managed to work through part of the chemo (just work part time) and do pretty much all normal activities.  Good luck with it!

  • Caya
    Caya Member Posts: 971
    edited March 2010

    Just had my regular semi-annual visit with my onc.  All is well.  Before I saw him, I stopped at the chemo room to say hello to the nurses.  They noticed my swollen left ankle/foot - asked me if I had been on Taxotere.  I said - yes, but's it 3 years already... They said they've seen this in several women who had Taxotere - something about capillaries being damaged. Lovely!!!

  • ktym
    ktym Member Posts: 2,637
    edited March 2010

    I think everyone is different.  I've heard some do well and some including myself have a hard time.  I've heard some say their Onc congrutulated them on their good attitude and that it was the reason they did well.  Some say they exercised every day and thats why they felt well.  Truth is many like myself who didn't do well exercised every day and tried to have a good attitutde too.  Its likely a coincidence and there is no guarantee about how you'll do except your own liver/kidney/enzyme make up that changes how you react to these drugs and their combinations.  They're doing better at finding which ones to give which cancer, but trying to predict how we'll metabilise them and individual SE profiles is research in its infancy.  All you can do it try it and hope your in the group who tolerates it well.  Exercise and attitude can't hurt and might help so you can throw that into the mix and good luck. If nothing else when its all over exercise helps with the recovery

  • waterlady
    waterlady Member Posts: 56
    edited March 2010

    I am currently doing Taxotere and Herceptin.  I have done 5 rounds of chemo and have one more to go.  In my case it is working wonderfully, and is well worth any side effects.  I feel fine the day of infusion, just a bit tired, but I think that is more from the premeds than anything else.  The next two days, I feel fine and by the third it hits me.  The SEs have been slightly different with each chemo, but totally tolerable, not fun, but tolerable.  I did have a reaction to the taxotere on my second infusion, but they upped the benadryl and gave it at a far slower rate, and I have not had a problem since.  I did have flushing (a flushed face) with the first infusion and was unaware that it was due to the taxotere.  I do find that the chemo is slightly easier to tolerate if I keep myself really well hydrated and drink lots of water. Please feel free to email me privately if you would like more info.

  • ccbaby
    ccbaby Member Posts: 985
    edited March 2010

    I did TCH (C-carboplatin) and just finished the Herceptin 3 weeks ago. During my first and second treatment, I had a severe allergic reaction to the Taxotere where my face turned bright red, I got extremely dizzy and my heart raced. The nurses had to flush me out with saline and give me more steroids, benadryl and decadron. They started over with a slower drip. On my third round, they gave me all of the extra pre-meds and slowed the drip, and I did fine from there on out. I had a lot of side effects that lasted mainly the first 10 days after the treatment. But, remember, everyone's side effects are different. I lost my hair 16 days after my first treatment. Just remember to drink A LOT of water, that will help flush out the toxins and chemicals.

  • writer
    writer Member Posts: 208
    edited March 2010

    I'm just back from my third Taxotere, taken along with Carboplatin, Herceptin and Avastin (I'm in the BETH trial for Avastin). I thought Taxotere was the same as Taxol, but today I was told no. A friend of mine who was in really great shape had a lot of muscle weakness, and I haven't had that, but it turns out she was on Taxol, which is known for that. Taxotere is not. I guess neuropathy is a risk, but I haven't had any. 

    I've had the usual stuff, hard to know what's from Taxotere and what's from the Carbo. But it's all manageable. First half of the three-week cycle is kind of tough, and second half I feel great, pretty normal, good energy. Moving as much as I can helps.

    My hair is actually growing back a little, and I have not lost body hair yet. Sounds like some of you didn't lose it all until tx 5 or even 6. I'm happy to keep my eyebrows as long as possible! 

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