Taxotere/neulasta pain - any suggestions?

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I need your help, ladies!

I've had four doses of taxotere/cytoxan and have two to go.  The pain and fatigue get worse with each successive treatment and nothing seems to help very much.  Here's what I've tried:

hydrocodone - helps a little but leaves me weak and slightly nauseated

tylenol - helps a little, but my liver enzymes are up so I'm trying to avoid it

hot baths - probably the best for pain relief but I can't stay in there all day!

claritin - no effect at all

I have violent reactions to morphine and oxycodone so those aren't an option. 

The pain and fatigue are so bad that I'm completely out of commission for a week or more each time and frankly, my whining is starting to get on my own nerves!  LOL  Any suggestions would be much appreciated!

E

Comments

  • crazy4carrots
    crazy4carrots Member Posts: 5,324
    edited December 2009

    Enjoyful, I am so sorry to hear about your bad reaction.  Do you think maybe it's from the neulasta?  Perhaps you could ask your onc to switch to neupogen for your remaining tx -- that is, if you're up to giving the (subcutaneous) shots to yourself, or have someone who can do it for you.  The neupogen is so much easier on the system.

    Hugs, Linda

  • lewing
    lewing Member Posts: 1,288
    edited December 2009

    I'm also sorry to hear that taxotere/neulasta is laying you low.  I second the other Linda's suggestion about giving neopogen a try, if you can (and if you have good prescription drug coverage - a factor that pisses me off no end).  I know each of us is an experiment of 1, and therefore doesn't prove anything, but: I had much less bone pain with neupogen (just a few twinges toward the end of each 10-day course) than the reports that I read from women on neulasta.  And I believe from my googling/PubMed-ing that severe bone pain *is* somewhat less prevalent with neupogen.

    As for taxotere - yikes, I hated that drug.  Blech.  It messed me up far more than A/C.  For what it's worth, the thing that helped me with the muscle pain was exercise.  It sounds counterintuitive, and it may be an idiosyncratic thing, but it did seem to help - the pain didn't go away, but it became more bearable.  I forced myself to get out every day for at least half an hour.  (Running is my exercise of choice, because I'm crazy, but a brisk walk would probably be better - and safer.  I still have scars on my elbow and knee from the times my leg spasmed and I hit the pavement.  Not good.  Come to think of it, swimming would probably be best of all, if that's an option for you.)

    Wishing you all the best,

    Linda 

  • Enjoyful
    Enjoyful Member Posts: 3,591
    edited December 2009

    Hi, Lindas!!

    Thanks for the suggestions.  I'll talk to my onc about neupogen vs neulasta, and I'll TRY to get out and move around.  It's so difficult with the fatigue and pain that even thinking about moving makes me cry.  But I need to put on my big-girl panties and give it a go.

    Stupid cancer!

    E

  • brendaw
    brendaw Member Posts: 47
    edited January 2010

    Enjoyful..

     This may be a stupid question, but are you taking steroids along with your chemo..neulasta shot.  I also get a lot of bone pain on day 4&5 after chemo..3&4 after the shot, but the steroids do take some of the pain away.  I have had 2 tx of the Taxotere and the second time was a bit better than the first.   I am with you as far as exercising goes.. it just seems to much to do at the time.  The neuropothy (sp)... is what gets in my way as far as that goes. 

    Brenda 

  • eliz46
    eliz46 Member Posts: 71
    edited January 2010

    Hi i had alot of pain with the neulasta shot also. My doc told me i didnt need it. becouse my white blood cells were high during my treatments.  some people dont need it to bring back the white cells. ask your doctor how high yours are. or check on the blood work paper they give you its called wbc on the paper

  • Drea36
    Drea36 Member Posts: 2
    edited January 2010

    I had a lot of bone and joint pain after my first Taxol/herceptin treatment. My onc prescribed me Gabapentin to help relieve some of the pain. It seems to be working because I have not had nearly the same level of pain as last time. After the first one I was lying in bed shaking from the pain, it was awful. I hope you feel better.

    Andrea :) 

  • tkone
    tkone Member Posts: 511
    edited January 2010

    Enjoyful,

    Acupuncture!  I had never done it, never considered doing it, thought the whole thing was a load of hooie but when I did my first round of T/C and had horrific bone pain I vowed that I would sell my soul if that is what it took to not have to go through it again.

    In desperation, I decided to try acupuncture.  I went the day after my next treatment and the difference was incredible!  I could function, I had fewer down days and I didn't have to take any pain medication besides tylenol for a couple of days.  I ended up going the day after each of my subsequent treatments and I never again had the debilitating bone pain that I had after the first one. 

    I'm a believer!  If you choose to try it, talk to the acupuncturist to see if they have dealt with cancer patients before, make sure they are licensed and that they use disposable needles. 

    Good luck!

    Tracy

  • Enjoyful
    Enjoyful Member Posts: 3,591
    edited January 2010

    brendaw -  Yes, I'm taking steroids with treatment.  I had a problem with steroid withdrawal, though, so we had to cut the steroids in half.  The pain lasts longer but I couldn't handle the psychological side effects of the steroid withdrawal.

    eliz46 - I did talk to my doctor about foregoing the neulasta and he said absolutely not.  Apparently taxotere really does a number on your blood counts and he doesn't think it's safe to wait & see.  Bummer!

    Drea36 - Does the gabapentin work immediately? 

    tkone - I'll try it!  Off to search for acupuncturists in my area...

    Thanks for all of the suggestions, ladies!

  • infohh
    infohh Member Posts: 71
    edited January 2010

    Hi

    I had 4AC followed by 4 Taxol.  I took neopogen daily after my first AC after the 3rd shot I had horrible pain that lasted for 24 hrs, I could not sleap or even  sit, I took maximum dose of panadol.  Onc switched me to neulasta but gave me Celebrex 6 hrs before the shot to load my system with pain killers and the pain was quit tolerable.  I had neulasta with my 3 AC, and did not need it with the Taxol. I had asked the Onc how important Neulasta was for my treetment, he explained that it made one less prone to infection, allowed more frequent chemo and therfore got it completed faster, but neulasta did not have a great impact on the succes of the treatment in fact for my case it had 0.3% better outcome.  .

    Hang on there JUST TWO MORE TO GO, you are in the worst spot now and all gets better from here.

    HH 

  • Luah
    Luah Member Posts: 1,541
    edited January 2010

    infohh: I just PM'd you.

  • scrappy_survivor
    scrappy_survivor Member Posts: 149
    edited January 2010

    Something that really helped me was a heating balnket. Kinda like the bath cause it is warm but you can leave it on you 24 hours if you like. HUGS

  • Enjoyful
    Enjoyful Member Posts: 3,591
    edited January 2010

    Great suggestion, mom!   Thank you!

  • SoCalLisa
    SoCalLisa Member Posts: 13,961
    edited January 2010

    Hi there

    Just wanted to drop in

    I had neupogen reaction of unbearable bone pain

    but we figured out that I could take half a dose and still

    get the white blood cells up without the pain...

    Hugs

  • Enjoyful
    Enjoyful Member Posts: 3,591
    edited January 2010

    Ahhh...I hadn't thought of that.  Maybe they can do that for the last shot (one treatment left) or maybe forego it altogether?

  • mdoney73
    mdoney73 Member Posts: 2
    edited February 2010

    My chemo meds are Adria and Cytoxin, I also get the Neulasta shot. I'm usually very ill within two days of chemo. I have severe bone pain and stomach cramps. I've also tried everything. Pain meds make me feel worse. The only thing that helps is my heating pad. I hope that you try it, and that it helps you as well! Good luck!

  • Enjoyful
    Enjoyful Member Posts: 3,591
    edited February 2010

    Thanks, everyone, for your help and suggestions.

    Here's what worked best for me:  acupuncture, exercise followed by heat, then naproxen.  As you can see, I tried a little bit of everything, and it worked!

    Thanks again!

    E

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