celexa

My Onc put me on Zoloft first. Did not work, switched me to Effexor XR, working much better, Ask to try something else. You have been on it so long you may have built a tolerance.

Hello:

I took Celexa many years ago

after all my Tx

and also some counselling with it

It worked for me

at the time and I did not stay on it

for a long while, nor did I take a large amount

Best to you

hope it helps

Sierra

Well, this study suggests in the short term citalopram was associated with neuroplasticity. http://www.ncbi.nlm.nih.gov/pubmed/19427633

This study looked at 12months of treatment in panic disorder. http://www.ncbi.nlm.nih.gov/pubmed/18090457

In this study, SSRIs were associated with some weight gain over 2 years; sounds like citalopram was in the middle of the group. http://www.ncbi.nlm.nih.gov/pubmed/15491240

In OCD, they are recommending treatment for at least 1-2years. http://www.ncbi.nlm.nih.gov/pubmed/14767394

"The more frequent adverse events (nausea, somnolence, dry mouth, increased sweating) are mainly transient, mostly mild to moderate in severity, and observed consistently across studies at rates similar to other SSRIs. Analysis of laboratory values, ECG, and vital signs revealed no unusual findings. Only a small, clinically unimportant reduction in heart rate was observed, similar to that seen with other SSRIs. Citalopram treatment did not increase risk of suicide, overdose, seizure, or arrhythmia. Thus, the pharmacodynamic, pharmacokinetic, and safety profiles of citalopram demonstrate that it is safe for use in adults with depression and depressive symptoms, including the elderly and patients with mild to moderate renal and hepatic disease." http://www.ncbi.nlm.nih.gov/pubmed/14561952

The database encompassed 1344 subjects treated with citalopram (20-60 mg/day) for a period of no less than 6 weeks. Statistically significant age-related distribution was found for five side effects: bradycardia, nausea, diarrhea, sweating and headache. Bradycardia was more prevalent in elderly (>65 years) patients as compared to the younger population (2.4% vs. 0.2%, P<.05), whereas gastrointestinal side effects, sweating and headache were less prevalent in the elderly. The age-related differences in the side effect profile may be attributable to altered sensitivity of the serotonergic system. http://www.ncbi.nlm.nih.gov/pubmed/12691792

They were using citalopram for 28 months in this study. http://www.ncbi.nlm.nih.gov/pubmed/11740983

In this study, up to about 15% of women had some sexual dysfunction by week 24. http://www.ncbi.nlm.nih.gov/pubmed/11270911

(1996 paper) Since citalopram was first approved in 1989, it has been prescribed to an estimated > 600 000 patients. An integrated safety database has been prepared, including data from 3107 patients from 24 clinical trials. In placebo-controlled trials, nausea, dry mouth, somnolence, increased sweating, tremor, diarrhoea, and ejaculation failure, mostly of mild to moderate severity, occurred significantly (p < 0.05) more frequently with citalopram. The excess incidence of these events over placebo was always less than 10%. In pooled comparative studies, citalopram's tolerability profile was similar to that of other selective serotonin reuptake inhibitors (SSRIs) and superior to that of tricyclic antidepressants (TCAs). Spontaneous adverse event reports arising from clinical use have confirmed the safety profile defined during the trials programme. Specific monitoring of all serious adverse events from around 10 000 patients receiving citalopram in clinical trials (including small open studies) has indicated a low potential for convulsions and extrapyramidal effects. There is no evidence of withdrawal phenomena on abrupt discontinuation, no clinically relevant effects on cardiac or laboratory parameters, and little or no effect on psychomotor function. When taken in overdose alone, citalopram appears to have a relatively wide margin of safety. Citalopram has been well tolerated in both short- and long-term use, and the profile seen in trials has been confirmed in the clinic. http://www.ncbi.nlm.nih.gov/pubmed/8732443