OncotypeDX- Slides

Gitane
Gitane Member Posts: 1,885
edited June 2014 in ILC (Invasive Lobular Carcinoma)
OncotypeDX- Slides
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  • Gitane
    Gitane Member Posts: 1,885
    edited September 2009

    If you have a minute please look at slide #106 in this slide set.  Instead of looking at the numbers on the right (5 year statistics) look at the events at the bottom of the slide.



    http://www.slideshare.net/fovak/breast-cancer-981022



    This is a slide about Distant Disease Free Survival, NSABP B-20 for Intermediate RS.



    Chemo + Tamox. 9 events/89 = 10% relapsed

    Tamox. 8 events/45 = about 18% relapsed



    That seems like a big difference to me.

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  • wallycat
    wallycat Member Posts: 3,227
    edited September 2009

    I am not sure I know how to interpret any of it....

    the previous slides show a 1% difference in chemo + tam versus tamox alone for both the 1-17 RS onco and similar 1% for 18-30 onco...but I am bad with math and stats.

    I emailed the slide link to my onco and we'll see if he responds with comments....

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  • Seabee
    Seabee Member Posts: 557
    edited September 2009

    Big difference, but a very small sample. I was most intereseted in slide 52, which cites risk rates for types a & b, Her2+ and triple negative, but specifically excludes lobular (most of which has characteristics like luminal a). Why? Why?

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  • Gitane
    Gitane Member Posts: 1,885
    edited September 2009

    Ya, Seabee, a VERY small sample.  I hope the TaylorX trial is based on more than this!  I'll look again at slide 52.  G.

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  • Kleenex
    Kleenex Member Posts: 764
    edited September 2009

    Man, cancer has really brought out the nerd in us, hasn't it? Guess it's something of a necessity. I, too, have now perused these slides. I'd LOVE to have the person who created them available to hear the speech that went along with them - and then we could ask QUESTIONS!! Oh well.

    Coleen

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  • Gitane
    Gitane Member Posts: 1,885
    edited September 2009

    Well, shoot. I just looked at the bottom of slide 52.  How typical is that!!  "Doesn't include lobular.... "  or "Includes only classical loblular ...."  If I had a dollar for every time I've read that in studies I'd be wealthy.  Even though we're thousands of women, the second most common BC, we don't enter into the big picture it seems.

    Who me? A nerd?  Ya, guilty as charged.  Or maybe just obsessed. Or both.  

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  • mymountain
    mymountain Member Posts: 184
    edited September 2009

    That was a HUGE presentation without any direct refrence to lobular.  I have been on the worry wagon about not having had any chemo, but looking at those slides, I am reassured that low/moderate scores may only benefit by as little as 1% by the addition of CMF.  Am I reading that right?

    MM

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  • Seabee
    Seabee Member Posts: 557
    edited September 2009

    Yes, you are reading it right. In my case it was 0%. Fat chance I'd do chemo just for fun.

    It's normal to worry occasionally about not doing what so many of us do, but when I review the facts of my particular case, I get over it quickly.

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  • hlya
    hlya Member Posts: 484
    edited October 2009

    I join the TailorXtrial,  the nurse told me the key objective of this trial is not to see the DRFS for the low score/high score group, but the intermediate group.  Guess they need more samples to study

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  • Anonymous
    Anonymous Member Posts: 1,376
    edited October 2009

    Hi LuA,

    I sent you a private message.

    Take care,

    Susan

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  • ibeejojo
    ibeejojo Member Posts: 45
    edited October 2009
    Hi ladies.....4 yr ILC survivor here.....The stats you are reading, as it was explained to me, indicate that chemo would be less than a 1% benefit if you scored low on the onco and therefore the risks far outweighed the benefits of chemo. The "little pills" work better for us than the chemo.  I consider this a blessing and the onco was brand new when I was dx'd....onc didn't even mention it.  I did run into Dr. Susan Love and she told me to cancel the chemo and have the test....God bless that woman!.....God bless us all..and he does....lol.  JO
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  • JannaC
    JannaC Member Posts: 30
    edited November 2009

    Dear Mountain,

     I too, have been on the worry wagon about not having chemo, my onco score was 19.  Also, so many of you with my diag had single or dbl mast.  I had a lumpectomy with dirty margins and then had a rexcision, with clear margins.  Radiation and now am on Femara.  I guess we just move on and stay on top of it.

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