tamoxifen allergy

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rhs15
rhs15 Member Posts: 3
tamoxifen allergy

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  • rhs15
    rhs15 Member Posts: 3
    edited September 2009

    I have been on tamoxifen since June for LCIS.  During this time, I have developed allergic symptoms. My family doc thinks it is the tamoxifen and so do I.  I have a call into my surgeon.  If it is the tamoxifen, are there drug alternatives to tamoxifen.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited September 2009

    the only other preventative medication used with LCIS is Evista, but only if you are post menopausal. What kind of SEs were you  having?

    Anne

  • rhs15
    rhs15 Member Posts: 3
    edited September 2009

    Swelling around my eyes.  Some extremity swelling.  All the symptoms coincided with when I started Tamoxifen.  The swelling started approximately 5-6 weeks into taking it.  Nothing else was changed during this time

  • Krisc
    Krisc Member Posts: 33
    edited September 2009

    Hey there!  I was diagnosed with LCIS this spring, and the oncologist preferred I take Evista.  I have been on it for about a month with no real side effects yet. Although my doctor says it generally takes about 2 months for any side effects to start.  I do think I am having more frequent hot flashes, but that could all be in my head:)  The oncologist preferred Evista over Tamoxifin because I am no longer having periods (54 years old), and it appears to have fewer side effects than Tamoxifn.  So talk with your oncologist about Evista.  Hope you get straightened out soon!  Take care!

    Kris

  • leaf
    leaf Member Posts: 8,188
    edited September 2009

     This textbook says the incidence of hypersensitivity with tamoxifen is extremely low. books.google.com/books?isbn=0781773288...

    This book states facial swelling can be a hypersensitivity reaction, so it has occurred in some people. books.google.com/books?isbn=0763779008...

    Just because its uncommon doesn't mean it can't happen.

    But allergic reactions can be strange.  Some immunological reactions to medications can happen months after the drug is stopped.  I had an on-again, off-again topical allergy (probably to latex) what was on a 5 year on-off cycle.  Luckily its been off the last 15 years or so.  

    But it is possible your reactions could be due to another cause.  Or, you may be one of the unusual people who do get hypersensitivity reactions to tamoxifen.

  • marle
    marle Member Posts: 12
    edited February 2011

    Hi everyone hope you all doing ok.friday is my big day for pulling out all my teeth.Oh my!not looking forward to this.My problem also start a hour after take my Tamoxifen at night.blocked nose,cough,sinus,hayfever,sometimes i cannot breath,the next morning my nose is blocked,cough,with mucus in my chest.My teeth is full of infection related to late side effects of treatment,so my dentist said he think my problem is my teeth.I hope so Tamoxifen is the best and i dont want this bc to recure.Luv.Marlé

  • Jeanc
    Jeanc Member Posts: 1
    edited February 2011

    I had stage 1 breast cancer with a lumpectomy.  No cancer in the sentinel or other lymph node but I developed a problem with the metholyene blue dye used and developed a blue scab which required another surgery.  Took so long to heal that I couldn't have radiation. ( that and the fact that I have asthma and the radiation would have hit my lung)  Had trouble with Arimdex (muscle pain) and Femara (pain and bad roseaca) and now I've developed an allergic reaction to Tamoxifen.  Hot dry face and lips, strange feeling in the tongue, asthma cough and itchy skin.  Went to the allergist and had a trial under supervision and he confirmed it.  Oncologist had never heard of it.  Has anyone else had something like this.  Doctor is now talking about mastectomy.  Really overwhelmed and don't know what to do.  I had one invasive and one in situ tumor -very small.  No other cancer cells found in the other surgery either.

  • rlchar3
    rlchar3 Member Posts: 11
    edited February 2012

    I have stage 1 breast cancer... lumpectomy was successful.  I am currently doing radiation and started tamoxifen end of January 2012.  Within the first few weeks of tamoxifen, I began experiencing side effects..  body aches and pains.  These went away but last week I started with a rash, swelling on my face and eyelids.  I now have cuts on my forehead and eyelids.  I stopped taking tamo yesterday and called the doctor today.  I have no idea wht other options I may have.  I would certainly hope that mastectomy is not my only other option.  Isnt is about playing the odds?  If I tested negative as a gene carrier and they caught it early... then my chance of recurrence is less than 20%.  Radiation reduces this and tamoxifen would reduce even further to about 10% combined.  

    How did your story turn out?

  • Lisa3375
    Lisa3375 Member Posts: 3
    edited April 2012

    After about six weeks on Tamoifen, I broke you in severe hives from head to toe.  I was in the sun at a baseball game & three days later I was hive covered.  I believe I have an allergy to Tamoxifen because of some severe itching & had before the hives.

    My care manager said she had never heard of this but I'm here to say - never say never. 

  • Cyborg
    Cyborg Member Posts: 848
    edited April 2012

    There is Feraston . I take that.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited April 2012

    if you truly are allergic to tamoxifen, you could try evista, providing you are post menopausal. (but since the hives and itching didn't start for 6 weeks, it may not be the tamoxifen). (it seems like you would've had allergy symptoms a lot quicker than that).

    anne 

  • Lisa3375
    Lisa3375 Member Posts: 3
    edited April 2012

    Actually, I discovered that allergic reactions can surface as far out as a year and a half after starting therapy.  I think the new initial itching was already a symptom and that started within a couple weeks but the sun just caused it to blow up massively.  My doc was very concerned because a reaction as bad as I had doesn't happen from many other things (ie: from eating shrimp your allergic to)  this reaction was systemic and severe.  It was boarding on Steven Johnson's syndrom & I won't even consider going back on Tamoxifen.  I will find another solution.

  • Carla56
    Carla56 Member Posts: 7
    edited January 2013

    Something weird is happening to me too:-( about 7 weeks after I started taking Tamoxefin I started to develop hay fever like symptoms. I started to sneeze ( mainly in the mornings) , my sinuses were full , so I spend the first 15 minutes when I wake up blowing my nose. I have also been getting a very bumpy scratchy ticklish palate/throat so Ive been taking Zytac for allergies what ever they may be.What should I do? I asked the pharmacist and she seemed to think it may have been around the same time they switched manufacturers of the Tamoxafin at the store, so she is going to order me more if the oringinal meds they had before the 2nd refill. I really hope this works as I wouldn't know what else to take...I'm peri menopausal:-( any suggestions would be helpful

  • MiniMacsMom
    MiniMacsMom Member Posts: 595
    edited January 2013

    Try a different brand they think I am had an allergic rxn to tamox teva brand. I switched to mylan with no problems. Its worth a shot. They have different in active ingredients.

  • 123penelope
    123penelope Member Posts: 42
    edited January 2013

    Were any of you able to get on a different medication. For now I take Aromasin, tamaxofen first.did not like the side effects. We each know ourselves better than anyone when something is not right, keep trying until you are satifsfied with that answer. Diagnosed 2011 LCIS

  • lallison
    lallison Member Posts: 29
    edited July 2013

    Thanks for posting this.  I also developed after a few weeks joint pain, migraines, inflammation, weakness, chronic fever, etc etc.  We stopped the tamoxifen and after about three weeks now the symptoms have begun to ease.  

    I would have been interested in trying something else but am not officially post menopause.  Almost but not quite.  In fact I had not had a period for about six months when I started tamoxifen.  Funny thing though I am now bleeding profusely and heavily....much more than I would have considered normal when I was having periods.  Am wondering if I should be concerned about this fine development. 

    I am kind of tired of doctors right now...I guess I should suck it up and see my GYN just to be on the safe side.  I bow to those of you who had more advanced stages of BC.  Just the little bitty LCIS I had to deal with is exhausting!

  • Jelson
    Jelson Member Posts: 1,535
    edited July 2013

    do go see the gyn - although your bleeding is most probably nothing serious and perhaps related to stopping the tamoxifen - a final insult?? better safe than sorry.

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