Any triple neg's getting Taxotere & Cytoxan only?

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Sandals
Sandals Member Posts: 104

Just wondering if anyone is getting the above chemo as I'm due to start end of June/beginning of July and wondering how well triple negatives take to this dose?  They've planned 4 rounds of this for me.

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  • jax65
    jax65 Member Posts: 47
    edited June 2009

    I am also triple negative and did TC only had last treatment today. In the beginning I questioned not getting Adriamyacin but onc said not necessary as they are finding it to toxic for the heart. Sure hope he was right I even questioned only 4 treatments but that is standard with node negative. Good luck to you as you start your treatment mine went by much faster that I thought it would.

  • Tamara1201
    Tamara1201 Member Posts: 70
    edited June 2009

    I'm also triple negative and going to be on 4 cycles of TC. I was supposed to start yesterday, but after getting to my doctors office, found out my liver enzymes were elevated, so they repeated them, and I had a CT of my abdomen with contrast this afternoon, and we will try again next week.  Now, I just have to worry about the results over the weekend, but I'm so sleep deprived from the steroid pre-medication I might just sleep all weekend, if I ever go to sleep

     Tamara

  • Debonthelake
    Debonthelake Member Posts: 244
    edited June 2009

    That's what I took.  Only I received 6 rounds.  The doc says it's just as effective and fewer side effects.  I sure hope he is right.  I'm sure glad that the chemo part is behind me.  Good luck.  You can do it.

  • tnt
    tnt Member Posts: 23
    edited June 2009

    I had 4 cycles of ac and my tumor went down.Then had 4 cycles of taxol and it grew back to the starting size .Thoughts are with you, i breezed through chemo wasnt as bad as i thought it would be .

  • KPolasek
    KPolasek Member Posts: 184
    edited June 2009

    Hi!

    I was 2cms, triple neg, stage 2a, grade 3 .... I had 4 rounds of the same.  They were not bad ... I completed my mine 2/26/08.  So far, so good.  The only problems I had were with neutrophils ... spent 6 days in the hospital after the 2nd round they were less than 1.  The third and 4th rounds I received shots to boost my white count.  The 4th round I had some trouble with the red count being too low as well -- got a shot.  Going through all this was hard but doable.  I worked as much as I could.

    Prayers for you!

    Kay

  • Sandals
    Sandals Member Posts: 104
    edited June 2009

    Thanks very much for the information.  Very helpful.

    I've a meeting with my docs next week to go through the treatment in more detail but she said on the phone this morning that I should be ok (not too much sickness) but on days 7-10, I may feel very low.

    I suppose I'm just so afraid of the unknown.  Once I get going with this at least I'll know what to expect.

  • ddlatt
    ddlatt Member Posts: 448
    edited June 2009

    I am also TN, stage 1, 1.2cm, grade 3. The oncologists I met with in Reno, where I live, recommended I have TC. I then got a second opinion from a med onc at UCSF, who is an expert in breast cancer treatment and research. He disagreed with the TC and recommended dense dose AC/T (taxol) which he said is a more aggressive treatment for TN, stage 3 cancer, which I agreed to since he is much more up to date on clinical trials than these guys here in Reno (I hate my oncs here for a number of reasons). I especially didn't want to take adriamycin, but I wanted to be as aggressive as possible, so that's what I had, AC for two months, Taxol for two months. I'm also having 35 tomotherapy radiation treatments.  

    with taxanes, neuropathy is common, and i definitely experienced that. the worst for me was the unbearable and incessant itching of my hands. i was miserable until finally i had a prescription for atarax (hydroxyzine), which i took every four hours for months.

    i wish i had known about oxycodone 5mg before i started chemo. the neulasta shot just knocked me for a loop, and the bone pain from taxol was awful, but once i finally got the right kind of pain meds, i felt nothing and chemo was a breeze from that point on. 

    i finished chemo on may 1st, and i have no more side effects, hair is growing back. i too was terrified of the unknown, and chemo was not at all as bad as i imagined.

    take good care!

  • pinkdove10
    pinkdove10 Member Posts: 80
    edited June 2009

    Hi.  I am TN too. but my treatement is different. I had 4 rounds of EC and then 4 rounds of Taxtotere. Mine was a stage 3. I have finished 6 rounds and waiting for the final 2 to be over.  Next will be the radiation.  Goodluck to u.

  • Sandals
    Sandals Member Posts: 104
    edited June 2009

    Thanks, I will mention AC/T to them next week when we meet.

  • carolinachick
    carolinachick Member Posts: 387
    edited June 2009

    I also had four rounds of taxotere and cytoxan, with my last dose on 4/22.  According to my onc, the adriamyacin has too many side effects (mainly heart-related) for use in node-negative TNBC.  The chemo wasn't as bad as I thought - mainly extreme fatigue - and the four doses went pretty quickly.  I did have severe reactions to the taxotere and had to be premedicated with steroids and benedryl.  Hang in there, Paulsgirl!

  • ddlatt
    ddlatt Member Posts: 448
    edited June 2009

    before i started AC, i had a MUGA scan to make sure my heart was strong. that's standard procedure before having AC. not everyone gets the same dosage of chemo drugs. it depends on your weight also. i weighed 102 and my dosage was 88mg adriamycin, 880mg cytoxan, and my UCSF onc told me that that was not at all dangerous for my heart. otherwise, i would have had second thoughts. 

    they will probably give you benadryl in your IV before administering taxotere (or taxol). i had severe burning of the veins with benadryl and a horrible rash on my arm. so they stopped giving it to me in the IV and instead gave me a pill. much better! it also cut down on the infusion time, which was great, because when i had taxol, the infusion time was 7 hours. it was only 2 hours with AC.

  • guitarGrl
    guitarGrl Member Posts: 697
    edited June 2009

    My treatment/what the doctor said is the almost identical to carolinachick's. I had a relatively easy time, though I also required extra benedryl because of a weird reaction to the Taxotere. I'm sure your doctor already knows about the dreaded A ...

  • Debonthelake
    Debonthelake Member Posts: 244
    edited June 2009

    Everyone has different ideas apparently.  But, my oncologist was trained at John's Hopkins and he assured me that the stats for Taxotere and cytoxin were good.  I was happy not to worry about the cardio side effects.  But, each of us has to make our own choices.  I had an allergic reaction to the Taxotere, but it was managed well with Benadryl, decadron and a solu-medrol dose pack.

    Best of luck to you.

  • ddlatt
    ddlatt Member Posts: 448
    edited June 2009

    i should have mentioned that my tumor was 1mm from the chest wall, and the surgeon could only get 1mm margin, which my UCSF doc and the pathologists do not consider clear margins. they consider anything 2mm and above a clear margin. so that is an additional reason why he recommended that i have aggressive AC/T chemo and radiation.  

  • White929
    White929 Member Posts: 53
    edited June 2009

    I am TN, Stage 1, Grade 3 with a tumor of less than 1cm.  I had a lump on 5/11 followed by another surgery to clear all margins (which they did) on 6/4.  I start chemo of Taxoter and Cytoxan on 7/2.  I will get 4 doses 3 weeks apart followed by 5-6 weeks of rads 5 days a week.  Good luck to you!!!!    Let's keep in touch1

  • carolinachick
    carolinachick Member Posts: 387
    edited June 2009

    White929 - Your treatment sounds just like what I had.  My first chemo was on 2/18/09, and I'm now halfway done with radiation (16 down, 17 to go!).  I'll be thinking of you as you start chemo!

  • Peggy5
    Peggy5 Member Posts: 3
    edited June 2009

    I had the same treatment CT, 4 cycles every 3 weeks,followed by 37 rounds of radiation. I finished chemo June 08 and radiation Sept. 08. It stinks but is very doable. The nurses and Dr's were very helpful addressing the side effects. My hair started growing back quickly and I went without any head covering by Aug 10th.
    I fell really good today ( one year later) and pray every night to stay this way. Don't try to be a hero- now is not the time. Take all the help you can and if you feel sick tell your Dr. 
    Every cycle was a little different so expect some change. I will be thinking about all of you! Hang in there-- the sun does get brighterCool 
  • holligoog
    holligoog Member Posts: 75
    edited June 2009

    I am TN and recieved 4 rounds of Taxotere/Cytoxan every 21 days. My last dose was on 5/6/09. I was told by my Onc that this TX was suffiencent for early stage TNBC. http://www.caringbridge.org/visit/hollisimpsongough

  • JourneyNC
    JourneyNC Member Posts: 69
    edited June 2009

    My treatments will be 4 rounds of the same chemo regimen followed by 6wks of radiation. The side effects are horrible for me. I hope my second round in July is better. Afterward, I will have 6wks of radiation. I just found out I don't have any WBC's and have to get booster shots to bring them up.

  • JourneyNC
    JourneyNC Member Posts: 69
    edited July 2009

    I got my 2nd round of Chemo treatment. 7minutes into Taxotere, I experienced nauseau then chest squeezing and a weird sensation from the chest up. My nosed closed and I couldn't breathe. I was light-headed from trying to catch my breath. They stopped the Taxotere immediately and gave me Atavan and Benadryl. My Onc was there who indicated I experienced an Anxiety Reaction from Taxotere. Scared me out of my mind, since my son was there to experience this episode as well.

    I'm halfway through...I'll keep truckin'

  • marielf
    marielf Member Posts: 15
    edited July 2009

    I was diagnosed with triple neg's and had surgery May 4 following a mamosite 5 day radiation treatment.  My TC 4 every 3 weeks beginns tomorrow.  Hope the chemo goes better than the radiation.   The Dr. said it would take @  2 1/2 -3 hrs.  I am having IV. 

  • carolinachick
    carolinachick Member Posts: 387
    edited July 2009

    Hi JourneyNC - I see that I'm just across the border from you, here in Fort Mill, SC.  I had a terrible allergic reaction each time to Taxotere and had to have benadryl and steroids before each infusion.  They also dripped it very slowly, so maybe your onc could try that.  Hang in there - my son also got to experience it!

  • JourneyNC
    JourneyNC Member Posts: 69
    edited July 2009

    Hello carolinachick, here in Charlotte, trying to get through this journey. Got jabbed with Neulesta after my 2nd treatment. I'm on top of the oxycodeine every 4 hrs for excrutiating bone pain...if not, I'm in a bad way.  I'm glad to know someone close by and hope we cross physical paths soon.

  • Jean12
    Jean12 Member Posts: 24
    edited July 2009

    Hello JourneyNC

    Nice to meet you, my name is Jean, the reason why I am responding is because I too am triple negative and will find out tomorrow what type of medicine that I will receive on July 15, 2009. I also had a reconstruction surgery done at the same time of mastectomy.  I hope that we can communicate more often, by the way, I was DX 05-06-09, IDC < Stage 1, 0.5 cm, Grade 3, 0/2 nodes, ER-/PR-/HER2-.>

  • Jean12
    Jean12 Member Posts: 24
    edited July 2009

    Hello Tamara1201, I hope this post finds you well, I just had to respond to your post because I has a daughter who's name is Tamara and her she was born on 12-01-77.

    Anyways, I hope that your tests came out well, I was DX 05-06-09, IDC ,Stage I, 0.5 cm, 0/2 nodes, Grade 3, ER-/PR-/HER2->

    I will be praying for you.

  • JourneyNC
    JourneyNC Member Posts: 69
    edited July 2009

    Nice to meet you Jean12, Let's talk further after your findings on 7/15.  Please PM me and we can chat or email and call each other for support. I'd like to know more of your reconstruction surgery and how that went. Stay Blessed.

  • tibet
    tibet Member Posts: 545
    edited July 2009

    Hi JourneyNC

    I had similar path report. Also DCIS and a 1 cm tumor. Was your DCIS also tested for ER receptors?

  • carolinachick
    carolinachick Member Posts: 387
    edited July 2009

    Hi JourneyNC,

    I'm sorry to hear that you're having terrible bone pain.  Hang in there and stay on top of those meds.  Hopefully your treatment will go quickly for you.  I just finished radiation last week - six months to the day after my diagnosis.  It has been a whirlwind.  We'll have to meet up sometime.

    Jennifer

  • JourneyNC
    JourneyNC Member Posts: 69
    edited July 2009

    Hello newalex,

    I just received a copy of my path report from my Hema Onc. office today.  Yes, they tested for receptors er, pr and her2 which are all NEGATIVE. BRCA1/2 are NEGATIVE also.

    Hello carolinachick,

    I got more meds today. Cried a river last night with pain having not taken the meds on time (every 4hrs). Most definately, I would love to share stories and meet you...and actually good gas prices down there too.   Smile

  • Jean12
    Jean12 Member Posts: 24
    edited July 2009

    Hello JourneyNC

    I'm glad that you responded to my post, I'm just getting ready for my doctor's appointment tomorrow, I'll be in touch  with you and will let you know which type of chemo I'll be getting.

    I don't see my PS until July 31st. I'm not sure how this works, what takes place first, when do I get my fills, chemo, expanders taken out replace with implant or what? I will most certainly ask the doctor tomorrow.


    Stay strong and may God bless You!

    Jean12

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