Elevated liver enzymes on Tamoxifen anyone?

Diane

I was told from the get go that Tamox is known to raise those #'s.....I just did a 12 hr fasting blood draw and will see my doctor this coming week so will see what it has done to my numbers as Ive been on it over 2 years and had slightly high cholestrol to begin with.

Best wishes

Jule

Hi:

Don't have that problem yet, but I take a supplement, milk thistle, which is supposed to promote liver health.  Good luck.

Peeps

I had my appt with primary care doc....she had ordered a 12 hr fasting blood draw to check things.....everything was really good, except(why does there always seem to be one of those?) my choloestrol has shot from 171 last August to 269 now....she put me on Lovstatin to see if we can get it down some....I also discussed the fact that tamox is know to raise this level and she said she read that but didnt realize how severly it can raise it.

She suggested have an intent conversation with my onco the end of this month about it to see what he says. She also faxed a copy of the report to him so he is aware of whats going on.

Will let you all know what onco says about this in a couple of weeks...I my appt for next week was changed to the 29th.

Hope everyone had a great mothers day!!!!

MOTC

From my understanding it can go either way...mine chose to go to the high side.

There are lots of articles on the net that state it increases liver enzyme levels....some of them say it increases the good and some say the bad....I personally think it is individual as I eat very healthy so have no reason to have that high of level.

My onco even warned me that it could go either way so they would be watching my levels every 6 months.

MOTC-yes I know about the genetics too....the docs say that at my age I would have had issue with genetically risen cholestrol prior....

My boss is one of those people who are healthy in all aspects of his life and has had elevated levels for the past 10 yrs, but he said they have always been high, no one has worried about them until the last couple of years.....he was dx'd with protrate cancer about a year ago,  so yes even healthy as a horse people do get ill.

Just got off the phone with my oncologist.  She was reviewing my records and is a little concerned about the AST and ALT.  She asked if I drink alot so we talked about that.  She recommended cutting back and then running another liver panel (I think that's what it's called) in one month.  She said she's not too worried about the cancer spreading to my liver.

I'm quite relieved.  Now, about the wine - I really do enjoy it, so this is going to be tough.  Got any ideas for support?

mmb1 I just was taken off Tamoxifen because cause of a enzyme I am lacking in the liver that makes it ineffective.  I guess this is a new test that just came out.  I was also put on Lupron and  start Arimidex soon.  How long did they say you will be on the shots and how often? Do you know if there are any major side effects like uterine cancer with Tamoxifen?  I have had  hot flashes and headaches also starting to get joint pain and can't sleep well. Is anyone else on Lupron experiencing these types of side effects.  I don't know what t of think about this Lupron stuff. 

Thanks, Diane

I know I need to get back to the gym, but my motivation is sorely lacking...  I'll think good thoughts for you

SoCalLisa, was your liver problematic before the tamox?  How did they discover you needed your gall bladder out?  That doesn't sound like fun!

Sunshine

I know this is am older thread but hoping someone will respond. I've been on tamoxifen for 4 years and suddenly within a year my liver enzymes are getting out of the normal range. I'm getting really freaked out. I'm not a drinker and don't understand the sudden change. This past year the dosage is went from one 20g pill to 2-10 mg pills once daily. That's the only change. My enzymes took a big jump always in the low range then to 40 and 50. Anyone else have similar story?

Also late to the thread. I've been on Tamoxifen for 10 months. My oncologist does not believe in scans or blood panels without symptoms warranting. I went for my yearly check up with PCP and today was told my liver enzymes up with AST at 60 and ALT at 69. It was 20 and 10 respectively before tamoxifen and at my last chemo in July 2014. I do not have a history of fatty liver. I shared the results with my oncologist who is recommending a recheck in 1 month. I'm wondering if I should push for an ultrasound or other imaging. Interested to hear other's experiences.

Dear Kitten1966,

Welcome to the community. We are glad that you reached out to our members and sorry about the liver enzymes. We notice that this thread is about a year old without recent posts. You may want to start a new topic to elicit more responses. Take a look at this question on our main site about Tamoxifen and Liver Enzymes. Keep us posted. The Mods