Tumor Marker blood test , anyone?

Can't find much info on this test, CA27.29, tumor marker blood test. Onc has been doing one from the start of my dx.  Today at my weekly visit he told me the # is getting higher.  In one breath he says he's "a little concerned" because prior to my surgery the # was 58 (then he tells me not to loose any sleep over it).  After surgery it was 28, which is below normal.  Then it started going up when I started on the Taxotere.  Last week the # was at 43.   Anyone experience this??  He says he'll retest next week and see what it is then.  He tells me that he sees fluctuations in his patients all the time with this and that it might not mean anything. that it could be the SE's from chemo, my sinus infection, blah blah blah. I finished chemo last Friday.  So excited to finish, then I hear this and now I am paranoid, it ruined my joy of finishing chemo!  Sorry for rambling on folks... wasn't expecting this one today! Any insight or experience with this tumor marker test would be appreciated.

Sue

Comments

  • lexislove
    lexislove Member Posts: 2,645
    edited March 2009

    Wouldn't it have been better if the onc just kept his mouth shut...and said to come back next week to redo?

    I'm so sorry about this stress. I'm not familiar at all with how sensitive these tests are.

    I'm at my 3 month checks and I never ask about them because of just this....up and down results. It could be this ..it could be that..BLA****

    I think all you can do is go next week and see from there. I know easy said than done...and try not to stress. I know you have finished the chemo and you just want to move forward now..and this has set you back.

    Do try to enjoy the fact that you have finished...and remember it can be many things, but we always go to the worse. Ahhhhh cancer the gift that keeps on givin.....

  • lindatwo
    lindatwo Member Posts: 122
    edited March 2009

    Susan,

    My general surgeon chose to check for the tumor marker before I had a mastectomy.  The result was 48.4, and she was excited about that; saying that because we knew I had cancer, they could re-check the test anytime in the future and be able to tell if the cancer returned.  She said sometimes even when they know someone has cancer the tumor marker will not reflect that.

    However, when I saw the oncologist, he was NOT happy that the test had been done.  He said it just confuses the issue because it is not at all consistent.  In fact after the surgery, he felt obligated to retest, and the marker number had actually gone up.  I have had every test known to man, and no cancer has shown up anywhere, but because my tumor is a grade 3, and because the CA 27.29 result is now higher, he feels that we should do chemo.

    I've decided that I will not put much emphasis on that number at all....it just seems like it is a fairly new test, and they don't know enough about what the results mean!

  • suemed8749
    suemed8749 Member Posts: 1,151
    edited March 2009

    Sue - Mine fluctuated all through chemo - started in the 40's - up and down somewhat . . . I got to be like Lexi - it caused me too much anxiety to even find out, so I stopped asking! Scared the crap out of me about a month and a half ago - my onc's PA left a message on my cell to to call her re test results. The only thing it could have been was tumor markers - and I couldn't get ahold of her ALL day. So all day, of course, in my mind, my markers had skyrocketed. When she finally did call me back, it was because they had DROPPED into the 20s and she wanted me to know. Great, but a very anxiety-filled day!

    My point is - I finished chemo in July and have been getting Herceptin every 3 weeks. Mine dropped 7 months after finishing chemo. It seems like this test is not extremely reliable - I wouldn't stress if I were you (but of course you will - like Lexi said, the gift that keeps on giving!)

    Best wishes - Sue

  • havehope
    havehope Member Posts: 503
    edited April 2009

    In March 08 when I found my lump CEA was 1.2 and CA 27.29 was 5.53.Back then my doctor told me not to worry is a cyst.

     In Sept CEA was 1.59 and CA was 27.29 was 14.03 - before surgery.

    After surgery, before chemo Nov 08 CEA was 1.3 CA 27.29 was 11.47 .

    March 20, 09 mid chemo (just started 12 Taxol) CEA was 0.7 and CA 27.29 was 10.

  • REKoz
    REKoz Member Posts: 590
    edited March 2009

    I realized as I was reading this thread that I haven't a clue what my tumor markers were ever. I have one more cycle of chemo to go (SQUEEL, SHREEK, Happy dance) and it's never come up. Nor before my bi-lateral mx in November. Part of me thinks now, "Geeze, this is stuff I should know." And then with reading all the apparent unreliability, I think that it's one less number I need to concern myself with. UGH!

    Peace-

    Ellen

  • swimangel72
    swimangel72 Member Posts: 1,989
    edited March 2009

    Ellen the same for me - my doctors never discussed tumor markers with me and I'm assuming it's because they may have never tested for them possibly because of my low Stage and Grade - possibly because they don't trust the numbers. I believe I have only 2 more infusions of Herceptin and then I'll be finished at the end of April (yay!) at which time I plan on asking my onc "what next"? I'll definitely ask more questions about tumor markers.

  • REKoz
    REKoz Member Posts: 590
    edited March 2009

    Swim Angel- Congrats on 2 more Herceptin! I cannot wait to be you! Since you are ahead of me, maybe somehow you can let me know what up with these #'s. I do remember my friend telling me that her Mom who had cancer years ago always has high tumor market #'s and has stayed cancer free.

    Ellen

  • susan13
    susan13 Member Posts: 732
    edited April 2009

    Simvog-what is CEA? And are you sure of the 5.53 ? or is it 553?   I was told anything below 34 was a "normal" tumor marker reading. So if your's was 5.53 when u found the lump...that means it was showing no cancer....?

    (where abouts in NJ are you?)

  • havehope
    havehope Member Posts: 503
    edited April 2009

    susan13:

    Here is some info on CEA.

    "CEA is used mainly to monitor the treatment of cancer patients, especially those with colon cancer. Following surgery, CEA values are helpful in monitoring the response to therapy and in determining whether the disease has recurred. CEA is also used as a markerfor other forms of cancer, including cancers of the rectum, lung, breast, liver, pancreas, stomach, and ovary. Not all cancers produce CEA, and a positive CEA test is not always due to cancer. Therefore, CEA is not used for screening the general population.

    When is it ordered?A CEA test may be ordered when your symptoms suggest the possibility of cancer. In patients who have been diagnosed with certain types of cancer, a CEA level is also measured before and after therapy, to evaluate the success of treatment.

    What does the test result mean?

    On initial testing, patients with smaller and early-stage tumorsare likely to have normal or only slightly elevated CEA values. Patients with more advanced tumors or tumors that have spread throughout the body are more likely to have high CEA values. When CEA levels decrease after therapy, it means that most or all of the CEA-producing tumor has been removed. A steadily rising CEA level is often the first sign of tumor recurrence.

    Increased CEA levels can indicate some non-cancer-related conditions, such as inflammation, cirrhosis, peptic ulcer, ulcerative colitis, rectal polyps, emphysema, and benign breast disease.

    Since not all cancers produce CEA, it is possible to have cancer but also have a normal CEA level."

    The CA27.29 was 5.53 with the tumor in me and yes it did not  indicate I had cancer. It still doesn't. That's why I don't trust these markers. It become elevated after the biopsy, but still no cancer. My surgeon said not to go by the markers in early stage. If the markers are elevated then it is a sign you should check yourself but if the markers are not up you should still check yourself if you are a high risk person or already have a lump. I waited until August to investigate the "cyst" and I ended up with a 4 cm tumor instead of 1.5 cm  which put me in stage 2. Thank God my daughter hit me by mistake and the tumor got big and swollen and bruised and ..... the rest is history.

    I'm in central NJ-Union county. Where are you? 

  • mzmiller99
    mzmiller99 Member Posts: 894
    edited April 2009

    Only my small two cents - my onco does the tumor marker thing every four months, but my rads onco and bs don't bother.  The readings can be useful, but are not that reliable.  They can be influenced by other, not related to cancer things. 

    I think if there was a huge fluctuation, perhaps, more testing would be in order, but I think it's just one more small tool in the war on cancer.

    Susan

  • susan13
    susan13 Member Posts: 732
    edited April 2009

    Thanks.   If this test isn't reliable I wish they wouldn't have to worry us about it!

    Simvog - I am in Ewing, just outside of Princeton.

  • swimangel72
    swimangel72 Member Posts: 1,989
    edited April 2009
    Well well - I just got a lab bill and there it is, on 3/11 a test for CEA was done and also for CA15-3. My onc never mentioned these tests to me nor their results........the nurse practitioner always tells me the same thing, "your blood work is wonderful." but I've been assuming it's the test she does just prior to Herceptin - to look at my red and white blood cell counts. So another thing to ask my onc........he of so little words, it's amazing when he says hello. Sigh........one more Herceptin tx to go........and then, you know what ladies? I think I'll be switching onc's yet again........for follow-up care I truly need an oncologist who will TALK to me and discuss things, not just breeze in and out with a pat on the shoulder. Frown
  • mmm5
    mmm5 Member Posts: 1,470
    edited April 2009

    Just an FYI, I have worked for a lab for 16 years and TM's are not the most reliable in Cancer detection. And as a footnote it is a known fact that the TAXANE group of chemo's make TM's go higer during treatment. Many ONC's don't test these during active treatment.

    I had an 18 prior to chemo then 35 after first taxotere treatment, now several months done with chemo and back down to 17.

    Do not panic while on Taxanes, wait for a few months after treatment!

    Swimangel, I so agree with you my ONC is the number one rated ONC in SW and I call it a Cancer factory it is just take a number and one size fits all, it causes me the greatest angst in all of this!

  • susan13
    susan13 Member Posts: 732
    edited April 2009

    mmm5, Thanks.  I needed to hear that!   My onc. always has said my blood work "is perfect", so if it's perfect why did he tell me he was "a little concerned" about the elevated tumor markers. Drives me nuts.  My CA27.29 after mast., before starting Taxotere, was 28, then after my last Taxotere it was 43. Kinda high though...?!?  Aghs.  I had it redone 2 weeks ago, but that was just 2 weeks after my last TX, and I asked him if it was long enough and he replied "I don't know"... If you don't know then don't worry me to death about itUndecided

  • susan13
    susan13 Member Posts: 732
    edited April 2009

    Well I had my appointment this morning and the last CA27.29 went up again, which was 2 weeks out of last chemo.  So Onc. has me going for ct, pet and bone scans.  He showed me the chart. Before 1st Taxo it was 24, then next was 34, then 43, then 51.  51 is kinda high... isn't it?!?  But it progressively went up during treatment, and was normal before... and I'm no medical professional but that seems too conincidental to me.  If not and I did all this chemo for nothing...... AGHS.  Ok , can't drive myself nuts over this.

  • mmm5
    mmm5 Member Posts: 1,470
    edited April 2009

    Try not to worry!

    My Onc's say they don't test TMs' until after a few months after the Taxane treatment.

    The scans are helpful to have baselines for future testing did you have any prior to treatment, that is usually when they do them.

  • susan13
    susan13 Member Posts: 732
    edited April 2009

    Just got the call and my most recent TM test is BELOW NORMAL!   WHOA!  WHY DO THEY MAKE YOU WORRY SO MUCH?!?!?!???

    I tried to talk my way out of the scans... but he still wants me to do them.  But I feel better now knowing the #'s are back to normal.

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