DCIS with less than 1mm microinvasion

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  • Beesie
    Beesie Member Posts: 12,240
    edited April 2009

    Kathy, thank you for the update.  The news about your nodes and the bone scan is great but I'm so sorry that you have more uncertainty and another surgery to come.  Fingers - and all other appendages - crossed that your surgeon is right and the mass on your colon is benign.  And that the PET scan doesn't turn up anything but an "all clear"! 

    ((((Hugs!))))

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  • Liz08
    Liz08 Member Posts: 470
    edited April 2009

    Since the below study applies to this forum, I thought that I would post an abstract I found on the ASCO website from 2008-

    Microinvasive breast cancer (Tmic): A descriptive mono-institutional report.

    Sub-category:

    Local-Regional Therapy

    Category:

    Breast Cancer--Local-Regional and Adjuvant Therapy

    Meeting:

    2008 ASCO Annual Meeting

    Printer Friendly

    E-Mail Article

    Abstract No:

    11508

    Citation:

    J Clin Oncol 26: 2008 (May 20 suppl; abstr 11508)

    Author(s):

    A. Ferro, A. Caldara, R. Triolo, M. Barbareschi, E. Leonardi, O. Caffo, M. Pellegrini, M. Frisinghelli, D. Bernardi, E. Galligioni

    Abstract:

    Background: Tmic is considered a separate pathologic entity with good prognosis, but its clinical significance and management remain controversial. We present our retrospective review of 69 cases of Tmic, among 6,023 BC pts (1%), observed at our institution from 1990 to 2007. Methods: We considered Tmic a single focus of invasive carcinoma < 2 mm or up to 3 foci < 1 mm in greatest dimensions (according to Silver and Tavassoli, Cancer 1998). Descriptive analysis of pts characteristics, treatment and clinical outcome are reported. Results: Among 69 women (mostly asymptomatic, presenting mammographic abnormalities, with median age 52, range 20-78), T< 1 mm in 55 pts (80%) and T< 2 mm in 14 (20%) were observed. Radical mastectomy was performed in 31 pts (45%) due to extended in situ component or multicentric disease, and breast conserving surgery (BCS) in 38 (55%). All pts but 4, received axillary node dissection (61 pts) or sentinel node biopsy (4 pts), with only 1 N+ pt. The "in situ" component presented ductal in 91% and lobular histology in 9% of the cases, with predominant comedo subtype in 45%. All Tmic presented ductal histology with positive hormone receptor status (HR) in 45%, negative in 22% and unknown in 33%. Among 32 HER-2 evaluable pts, HER-2 was overexpressed in 34% and normal in 66%. Adjuvant treatment consisted of radiotherapy in 87% of BCS pts, chemotherapy in 5 HR neg pts, endocrine therapy in 7 and chemo-endocrine in 1 N+ pt. At a median follow-up of 93 months RFS and BC specific OS were 91 and 100%, respectively. Three pts experienced a local relapse (2 DCIS and 1 invasive) and 1 distant metastases (bone). None of relapsed pts had received systemic adjuvant therapy. Three pts died for non-breast cancer causes. Six pts developed a controlateral BC (9%): none of them progressed or died of disease. Conclusions: Our data appear in large part comparable to those of the literature on Tmic and, in our experience, the inclusion of microinvasion > 1 mm and < 2 mm did not change the good prognosis of microinvasive cancer.

    The above is cut and pasted word for word.  Wishing everyone the very best.

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  • Liz08
    Liz08 Member Posts: 470
    edited April 2009

    Kathy-

    great news about your bone scan and nodes!  So sorry to hear about the mass on your colon but good to hear that the doctor believes that the mass is benign.  Don't you just love it when the doctors speak to you about your results and say the good part is blah....blah....blah but the not so good part is blah....blah....blah.  Meanwhile all you want to do is move on with your life and put all of this behind you...we all understand since we have been through it.  I have been experiencing this from my doctors lately but we have to remind ourselves that they are only human and all we can do is pray for strenth to get throuth this.   I''m wishing and praying that everything comes back normal and B-9 for you!   The waiting is the toughest part but you will get through it and believe it or not you will be able to move on. Also, it sounds like you have great doctors who are very thorough and want to cover all bases.  

    Sending (((hugs))) your way and keep us updated.

    Liz

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  • Liz08
    Liz08 Member Posts: 470
    edited May 2009

    Thought I would bump this up for the new members.

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  • Liz08
    Liz08 Member Posts: 470
    edited February 2010

    Hi-

    for those who had microinvasive DCIS that was her2+++, as of this afternoon we have our forum index (thanks to the moderators!).  Please feel free to post there. We can finally connect! The forum index is called Micro-invasive DCIS that is Her2+++.  Thanks!  Liz

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  • laurakay
    laurakay Member Posts: 109
    edited May 2010

    bumping this

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