FlaLady -did you ever find out about Miltex

Miltex
    
     Miltex was originally developed in Germany as an oral treatment for
breast cancer. It is a derivarive of Phosphocholine. Chemically it is a sort of
lipid. It has been tried internally in the treatment of breast cancer, but
the concentations needed to treat breast cancer are too toxic on the GI tract
to be effective.
      While the concentrations needed to treat breast cancer internally are
simply too high, oral Miltex is very effective in treating a parasitic
protozoal infection known as Leishmaniasis, which is endemic in India and spread by
sandflies. It is given in a dosage of 100mg /day for 28 days and can cure
94% of the Kala Azar infections.
       Topical treatment of the skin mets of breast cancer with Miltex is
another matter. The drug has been used, and is being used to treat this
situation..It is applied as a 6% solution and the dosage is, for the first week, 2
drops of the solution per 10 cm2 of affected skin applied daily. If there are
no, or minimal local side effects, the dosage is increased to 2 drops of the
6% Miltex solution per 10 square centimeters of affected skin tissue, twice
daily.This dose is continued, more or less, as long as it is effective and
there are no severe local side effects.The main local side effects are itching,
burning, desquamation, and irritation. Apparently skin that has been
irradiated may be more sensitive to the effects of Miltex solution. The success rate
for the treatment of the skin mets of BC is about 40%. Systemic absorbion of
the drug from the skin is minimal.
 Some Oncologists have dropped the dose to one drop/ 10 sq centimeters
affected skin surface, two times a day if 2 drops are too irritating. After the
solution is dropped on, it is gently rubbed into the lesion and surrounding
tissue, very gently with the fingers, enclosed in a rubber glove. Since people
on the board have used Miltex, they can give you more explicit directions on
actual use. Overall the topical use seems safe.
      The mechanism of action of Miltex against breast cancer skin mets is
not exactly known. It seems to increase the intra- cellular concentrations of
Ceramide about 53%. Cetrimide is a lipid that is very involved in Apotosis or
programmed cell death. Its kind of complicated, as there is an abundant
lipid in the cell surface called Sphingosine. Depending on enzyme activation,
Sphingosine can be changed to Ceramide and induce apoptosis (an anti-cancer
action) or can be phosphorylated to Sphingosine Phosphate, and act to stop
apoptosis (a "pro cancer" action). Miltex seems to push the cells to produce more
Ceramide and this leads to cell death. Of course, this is a simplified
explanation.
    Miltex also inhibits Protein Kinase C (PKC) and PKC inhibition leads to
inhibition of the RAS signaling pathway which is very involved in the growth
of tumour cells.

Lady Y.     Miltex worked for a while with skin mets that were just breaking
through the skin. Then it stopped working. One time my skin mets got bad
like yours sound, and at that time I started ABRAXANE which worked really
great but only for 3 months, but while it was working, the skin met blisters
and bleeding just melted away and healed. I was so pleased. I thought I
had found the answer. Then it quit working. The mets got bad and I had
radiation again which helps greatly for a while but then the mets come back

I hope this is where to post questions as well.  I ordered Miltex (oncologist-assisted) about a month ago.  I have not heard from them.  Followed up with a letter about a week ago.  I realize it is in Germany - but does anyone have any idea as to the process to be approved, ie - how long does it take - do they have additional criteria, etc.