Maitake mushroom md fraction
Here is a link to some interesting research on the use of Maitake mushroom D (sorry, not MD as in the my title post) extract on human cancer patients. The numbers of patients involved were small, but the results do show some promise. They show the results of both chemotherapy and combined chemo with maitake extact on various cancers in patients. Breast cancer was among the types of cancers that showed a positive response to the treatment.
Here is the conclusion of the study:
Since the cultivation method of Maitake mushroom was established in mid 1980's, this legendary and delicious mushroom has gained much popularity among Japanese people. Anecdotes and folklore on its medicinal values have also been elucidated by a number of mycologists and pharmacologists and its strong anti-tumor activity has attracted many researchers. It should be noted that, unlike many other mushroom extracts that have to be injected intravenously, Maitake D-fraction has a strong ability to inhibit tumor growth when given orally as well. In this context, various tests were conducted focusing on inhibition of growth and metastasis of cancer after surgery, by oral administration of Maitake. Even though this was a limited and non-controlled trial, the clinical study indicated that Maitake D-fraction is effective against such cancers of the breast, lung, liver, prostate and brain. Both human and animal tests demonstrate a synergistic effect with chemotherapy while ameliorating severe side effects from chemotherapy. Though the data is preliminary, the results of animal (and limited clinical ) studies based on Maitake D-fraction suggest significant healing and preventing potential for cancers and other immune-related health disorders. It is important to note that even among Maitake Mushrooms (Grifolafrondosa),there are many strains and some contain very little Beta-glucan,the active ingredient to stimulate the immune system. From such strains of Maitake, D-fraction may not be obtained.
I'd say its important to read the study yourself,and recognize the limitations, as some of it is animal studies, and the human studies were small in number, but impressive nevertheless.
http://www.orthomolecular.org/library/jom/1997/articles/1997-v12n01-p043.shtml
Anyone find any more studies conducted to further this research from 10 years ago?
Comments
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great article Timothy, very interesting, I found this study
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I'm trying to find some follow up work to those older studies. The MSK site has a writeup on Maitake and lists references. One from 2008 on lung cancer metastasis on mice was published.
How do you insert a link?
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American Cancer Society has a good writeup, and says two studies are underway in human to look at combining Maitake D extract with conventional treatment. Here's a link to the ACS writeup that is good and no-nonsense.
http://www.cancer.org/docroot/ETO/content/ETO_5_3X_Maitake_Mushroom.asp
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2008 Journal of Clinical Oncology. A study on humans, breast cancer patients, postmenopausal, NED, dosage trials to determine how much produces what immunological response.
Conclusions: Oral administration of a polysaccharide extract was associated with measurable changes in peripheral blood. The dose associated with the most significant changes varies by immunological parameter. The dose of 6 mg/kg is selected as the dose in future studies with clinical endpoints.
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Some more work on human cancer patients looking at various blood indicators of immune activity. Not sure how they came to their conclusions, but they concluded it had an inhibitory effect on metastasis.
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Thanks for sharing the info. Very Useful. Now I'm interested in the properties of Maitake mushroom.
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Thanks for the info--good to know.
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