Anyone ER/PR, HER-2 all positive?

Hello audrynyc.  I was diagnosed with the same as you for a while.  I did get chemo and herceptin until another onc said that I wasn't HER2+ according to FISH testing.  I had three FISH that were negative and one IHC that was 3+.  I had 4 Herceptins with AC +T.  I read on the Herceptin site that there are some false positives.

Were you tested with IHC or FISH?  FISH is supposed to be more accurate and....I am thinking that I read somewhere that ER+ and PR+ isn't often Her2+.  I could be wrong.  Most likely I am wrong.   I do remember reading that slow growing grade 1 BC is often not Her2 +.

Good luck on the Oncotype test.  I had positive nodes so had to have chemo.

We are very lucky to ahve herceptin.  Did you see the Lifetime movie last night?  It was great but was a tear jerker.

Shirley 

Hi Audrey - I'm also "triple positive. My oncologist was shocked when my Fish report came back highly Her2+ (because my tumor was only .9cm - and grade 1). My Oncotype Dx score was 22 (low-intermediate) so he said I would need Herceptin with chemo. Since I had a mastectomy, he decided that a mild-type of chemo would be sufficient, since Herceptin works well with any chemo, so he put me on Navelbine for 4 months. It doesn't hurt your heart - and wouldn't make me go bald. I'm done with it now - and will continue Herceptin for the full year. Since I'm post-menopausal, I'll be on Arimidex for 5 years.

You can find out more information about Her2+ breast cancer at this web site:

www.her2support.org

What stage and grade is your cancer? If there is any doubt if you are Her2+ you should ask your oncologist to have your tumor sent out for a FIsh test. BC IS overwhelming - but the women here are very informative and supportive so you came to the right place!

I am diagnosed the same as  you.  I am scheduled for a Mastectomy on Oct 27 and I suppose they will do further pathology then.

I was kind of freaked out when I first came to the site because I didn't see a lot of people with the  +++ either but its great to see more each time I come!  Actually its not GREAT but its great since we are all in the same boat.  I wish none of us were dealing with this at ALL!!!

Triple positive for me too. I've noticed quite a few on the boards over the last several months. Thank God for Herceptin!!!

Another triple positive here.  My tumors (DCIS and IDC) together measured < than 1 cm. My onc. said because of the very tiny nature, and because I had a mastectomy, I had treated the cancer aggressively enough, and said that chemo wouldn't benefit my survival chances that much at all.  I  really wanted Herceptin, but without chemo, I couldn't get it.  So, I have been on Femara only for the past 2 years, and so far have been cancer free.  Hopes this helps.

Jennifer

Hello, I also was dx'd with ER+/PR+ and Her2+ in 6/06. I had multi focal tumors-3 total, the largest measuring over 2.1cm.. with lymph (21 removed) and vascular invasion...I had a mastectomy, chemo, radiation and Herceptin (actually cut short by 2 tx's because of side effects) I am 2 yrs out as of 8/06...I did see the movie on Lifetime twice, though hard to watch I am very grateful to the Doctor who was persistant in discovering this drug...triple + and still going strong.

I am triple positive as well.  I am 37 and starting Chemo + Herceptin this Friday, November 7th.  I am terrified of it.  I had a bi-lateral mastectomy on 9/16/08 for extensive DCIS in my left breast.  I opted to do the right breast to in order to be aggressive with this.  However my pathology came back with a very small tumor (.4cm) in addition to the DCIS.  It also showed I am ER+ PR+ and HER2+++.  So in order to get the Herceptin I will also need to do chemo.  I am opting to take Taxol/Herceptin  weekly for 12 weeks and then continue the Herceptin for a year.  I haven't read of too many people do this without the "C".  However, my Onc felt these side effects would be less harsh on my body, ovaries, etc.  I am praying I am making the right decisions.  I didn't do the OncotypeDX test because my Onc said that because of my age and the + HER2 results, plus the other pathology information, it was felt I would be in the "high" risk group.

LuLu2011,

It can take up to a week.  Call your surgeon and ask if they are in yet.

Hope this helps.