Femara and vision problems

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5graces
5graces Member Posts: 99

I have been on Femara for 18 months and have tons of se's.  My latest is a rapid incease in vision problems, so yesterday I went to eye Dr.  She said that my vision was terrible ( I already knew that!!!) and prescribed new glasses (which by the way has not helped) and she said I have lots of stuff going on with my eyes...cataracts and some pressure in my eyes so she set me up for glaucoma test next week.  I told her that I was taking Femara and she acknowledged that it does cause vision problems, but she didn't elaborate.  I am so scared that I may lose my eyesight!  So, I have decided to stop the Femara between now and the time for my exam and see if it will help.  There is no glaucoma in my family.  Anyone else having vision problems with Femara?

Comments

  • saluki
    saluki Member Posts: 2,287
    edited August 2008

    I've had dry eye since I started Femara.  Fosamax made it much worse.  I stopped the Fosamax when I had a tooth extraction and my eyes got better.  I started a Zometa and since have had nothing but problems with my eyes.

    The thing that really irritates me is I went for Lasik sugery and they were well aware of the medications I was on; but apparently they didn't know the side effects of the medications, since Lasik drys the eyes.----Eyes glued to lids daily.   I need to seriously deal with this.

  • Member_of_the_Club
    Member_of_the_Club Member Posts: 3,646
    edited August 2008

    I am on tamoxifen and have cataracts now but one one was staring before bc so i think the drug may have accelerated things but they would have happened anyway.  Many of these vision issues are a natural part of aging.

     I don't know about glaucoma, never had it, but i have had, in addition to the cataracts, a detached retina and now vitreous detachment with stress son a thinning retina.   I've had a lot of vision problems in my life, but most are treatable.  Cancer is much, much worse, so I don't question the drugs.

  • Member_of_the_Club
    Member_of_the_Club Member Posts: 3,646
    edited August 2008

    Oh, and I am in my mid-40s and had the detached retina when I was 30.  Some of us just have bum luck.

  • jinky
    jinky Member Posts: 746
    edited August 2008

    I am having a real problem with my eyes.  Been on femara for 9 mts.Can only stay on computer a few minutes at a time. Very dry eyes even thou i use the drops about 10 times a day and salve at night.

    I am going to get plugs Sept 17 so will let you know if iy helps.

    My eyes sight has gotten a lot worse with femara

    .bc and le hugs jinky

  • jude14
    jude14 Member Posts: 293
    edited August 2008

    I started on arimidex in Dec.2007 on it for 2 months switched to femara and I have now gotten so I cannot stay on pc long my eyes hurt and I get dizzy.  I just saw an eye doctor and he said no change since last year.  I have been on the femara for 6 months. 

  • 5graces
    5graces Member Posts: 99
    edited August 2008

    Thanks everyone for your reply....I have had second thoughts about stopping the Femara right now and just skipped taking it for one day.  I will post back after my glaucoma exam and hopefully have more info on what may have caused it....and I also am aware that my age could be partly the reason....I'm 61.  This just all seems to have progressed so fast!

  • jinky
    jinky Member Posts: 746
    edited August 2008

    Has anyone had problem from femara and swithed to another one without the eye problems? Did 5 yrs of tamoxifen.

    Jude why did you swithch from arimidex? Did you have eye problems on that one?

    I had very little problems on tamoxifen....just terrible hot flashes/

    Which is best..arimidex or aromasin?

    Thanks for your help.

    bc and le hugs jinky

  • 5graces
    5graces Member Posts: 99
    edited August 2008

    Yes jinky.....that is exactly what I want to know, if I quit the femara will the vision problems go away?....or at least improve.

  • jude14
    jude14 Member Posts: 293
    edited August 2008
    Hi jinky...I switched from arimidex because the joint pain got so bad I could not walk across the living room floor at times.  I did better on the femara for about a month and now I am right back where I was on the arimidex.  I am taking arthrotec and osteo bi-flex triple strength and arthritis advantage all three and livng with a torn up stomach right now.  My eyes are so dry and I think I have at least half of the side effects from these pills....Cry  I was told I could try the aromasin but as of yet I have not tried I figure if I have problems with 2 of the AI's then the third one will be no better.  I have been told by people who have quit the pills that the symptoms go away after awhile usually....I wish I knew for sure so I would no what to do as for continuing on with these pills.......
  • jinky
    jinky Member Posts: 746
    edited August 2008

    Grace and Jude 14  and others please lets keep in touch and let me know how you solve this problem. Praying the plugs i will be getting work on Sept 17.

    My eyes are so bad it is all the time now. Send me private messages or whatever and please let me know if you stop femara and start another .

    bc and le hugs jinky

  • 5graces
    5graces Member Posts: 99
    edited August 2008

    Hi jinky....just got back from the eye Dr. and i do not have glaucoma after all.  At my last visit I showed some pressure in my eyes but this time there was none, just a cataract.  So I don't know still what is really going on with my eyes.  The Dr. did not know if the Femara was causing my problems, but i think it is.  Some websites I have visited definitely says that Femara causes cataracts and blurred vision.  So guess I will stick it out at least until my next Onc. visit in October.  I hope the plugs work for you.

  • Karens7
    Karens7 Member Posts: 3
    edited July 2014

    I have been on Femara about a year and a half and thought my glasses needed replaced.  I have been having trouble getting the correct prescription.  I have gone back 3 times.  It seems like every time I go back they are different.  I am having trouble reading.  Also, after I have been on my pc or phone for awhile I have trouble focusing.  Does anyone know if after one stops taking Femara does your vision get better?  

  • Karens7
    Karens7 Member Posts: 3
    edited August 2014

    I have the beginning stages of getting cataracs now.  My eyes are driving me nuts.  I love to read and now it is hard to do.  I just want to know if the vision will get better once one stops the meds.  I am really thinking of quitting.  I had cancer on my left side in the early 90's and took tamoxifen and still got it in the right side 12 years later.  Wonder if these meds really help.

  • Kicks
    Kicks Member Posts: 4,131
    edited August 2014

    I have been on Femara/letrozole since Feb 2010 and have had some eye issues.  I do intend to stay on Femara/letrozole as it has apparently done what it should for me - I'm 5 yrs post DX with IBC and still NED.

    I did develope cataracts in both eyes and have had retinas detach in both eyes.  None of my Drs say they can say what caused the issues - could be chemo, could be Femara/letrozole, could just be getting older, could be all the years I spent outdoors with light green eyes, coulc be a combination of all/some/none.  Can never know for sure.

    I wrote of my eye issues in the 60+ Forum in the Age Related Macular Degeneration thread if anyone is interested.

  • doxie
    doxie Member Posts: 1,455
    edited August 2014

    I've not taken famera yet but started with arimidex and am on aromasin now.  I developed seriously blurred vision on both meds.  Also had PVD in one eye, often caused by a severe drop in estrogen as in menopause, post pregnancy, or start of AIs.  Mine happened when I restarted AIs after a two month holiday to see if arimidex was causing severe blurred vision.  

    It turns out that my blurred vision is primarily caused by a problem with clogged meibomian glands from blepharitis.  Not sure if this started on chemo, but I noticed the swollen eye lids then.  However the AIs made the problem much worse.  

    If the meibominan glands in the eye lids are clogged, the eye doesn't have the film of oil that keeps tears from evaporating.  My eye produce enough tears, but could not keep them on the surface on the eye.  After two years of using drops all day, my new routine has made marked improvement in my eyes.  Not perfect, but better.  I scrub my eye lids with diluted "no tears" baby shampoo and use a hot compress on them to help open the glands.  This twice a day.  

    This is a helpful website to visit.  http://www.aoa.org/patients-and-public/eye-and-vi...

  • Blessings2011
    Blessings2011 Member Posts: 4,276
    edited August 2014

    A year on Arimidex and six months on Femara..... I can't recall when my vision started to get blurry, but a visit to the ophthalmologist ruled out any serious eye problems, cataracts, or glaucoma. What I had was a case of very dry eyes, and he prescribed OTC drops. That solved the problem.

    I quit the Femara three months ago, so I no longer need the drops.

    (Makes sense though - the AIs dry everything else up - why not the eyes?)

  • marijen
    marijen Member Posts: 3,731
    edited October 2017

    bump


    Breast Cancer Medications and Vision: Effects of Treatments for Early-stage Disease


    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC32058...


  • marijen
    marijen Member Posts: 3,731
    edited October 2017

    Visual Impairment in Myopic Patients With Breast Cancer Receiving Adjuvant Therapy With Aromatase Inhibitors

    Richard J. Epstein. Author links open the author workspace.Opens the author workspaceOpens the author workspace
    Medical Oncology Unit, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong; and the Hong Kong Sanatorium & Hospital

    Received 23 October 2008, Revised 26 March 2009, Accepted 13 April 2009, Available online 19 August 2011.

    Show less

    https://doi.org/10.3816/CBC.2009.n.030Get rights and content

    Abstract

    Retinal structure and function is maintained in part by the trophic effects of aromatase, a cytochrome P450 convertase responsible for local tissue estrogen synthesis from androgen precursors. Herein, we report deterioration of visual acuity in 2 Chinese patients with breast cancer and preexisting myopia who had recently commenced adjuvant hormonal therapy using the aromatase inhibitor exemestane. Given the neuroprotective functions of estrogen and aromatase, we caution that this timing might not be coincidental. Prompt ophthalmoscopic evaluation is thus recommended for any patient who is prescribed treatment with an aromatase inhibitor and subsequently develops visual symptoms.

    Keywords

    Anastrozole

    Exemestane

    Letrozole

    Macular hole

    Retinal detachment

  • marijen
    marijen Member Posts: 3,731
    edited October 2017

    from Sas

    Mari, The Vitreous clouding---are you under the care of a Retinologist? I developed wet macular degeneration in Nov. 2016. I have rec'd 5 eye injections since. Oddly, when I had the first eye scan, the technician dropped in conversation that I was the 4th of 8 patients that day that had a history of BC. Eye fluroscien scans can be done for many reasons. Was it a fluke that 50% of that days patients had BC or is it a problem unidentified? I tried to address it with the doc. He blew me and the question off. I checked the net and there is very little info on chemo(1) and AI's(0). Initially, I figured this is an area that has been ignored b/c the connection isn't being made. WHY? It's not the retinologists body part or problem. Direct eye cancers are rare. They don't tend to think outside their body part. A friend recently entered a new trial, and for the first time an opthamologist evaluation was part of the work up. So, what's your complete history on this?

  • marijen
    marijen Member Posts: 3,731
    edited October 2017

    2015 Mar 20;9:549-52. doi: 10.2147/OPTH.S80754. eCollection 2015.

    Vitreous estrogen levels in patients with an idiopathic macular hole.

    Inokuchi N1, Ikeda T2, Nakamura K3, Morishita S2, Fukumoto M2, Kida T2, Oku H2.

    Abstract

    PURPOSE:

    Estrogen, a female hormone, activates collagenase and might be associated with the pathogenesis of vitreoretinal collagen fiber disease. The purpose of the present study was to investigate the vitreous levels of estrone (E1) and estradiol (E2) in subjects with an idiopathic macular hole (IMH).

    METHODS:

    Vitreous samples were obtained from ten female patients with an IMH and from nine female patients with other retinal diseases (six with rhegmatogenous retinal detachment and three with age-related macular degeneration) as a control at the time of vitreous surgery. E1 and E2 levels in the vitreous samples were then determined using the Coat-A-Count(®) Estradiol Radioimmunoassay (RIA) Kit and the DSL-70 Estrone RIA Kit, respectively.

    RESULTS:

    The mean vitreous levels of E1 and E2 in the subjects with IMH were 1.83±2.00 pg/mL and 7.03±2.97 pg/mL, respectively, whereas in the control subjects they were 2.42±1.25 pg/mL and 4.90±2.90 pg/mL, respectively. Thus, the vitreous E2 levels in the subjects with IMH were significantly higher than in the controls (P<0.05).

    CONCLUSION:

    The findings of this study suggest that E2 might be associated with the pathogenesis of IMH, but further investigation is needed to elucidate that association.

    KEYWORDS:

    estradiol; estrone; idiopathic macular hole; radioimmunoassay; vitreous surgery

    PMID:
    25848205
    PMCID:
    PMC4376308
    DOI:
    10.2147/OPTH.S80754

    Free PMC Article

  • marijen
    marijen Member Posts: 3,731
    edited October 2017

    My opthamologist told me today that Letrozole can cause swelling at the back of the eyes. He took photos, haven't received an answer if there is swelling or not but he couldn't "see" any with other tests.

  • 5graces
    5graces Member Posts: 99
    edited August 2017

    A belated update on my original post......I finally had cataracts removed from both eyes in 2015 and my vision is so good now that I just have to wear glasses occasionally and they are a very weak prescription....mostly just wear them to try and conceal the fact that I have no eyebrows and eyelashes...lol :-) they have never come back and I guess never will...but that's Ok. Much bigger problems than that. I'm back on Femara....letrozole this time around.....since my second bc diagnosis in 2015, 4 months after my cataract surgery. I still believe the Femara contributed to the cataracts. I have been on letrozole for 14 months this time and just as before my se's are horrendous. But, I'm just going to give it all I have and stay on it as long as I can. I am stage 3a this time. I turn 70 in 2 weeks.

  • marijen
    marijen Member Posts: 3,731
    edited October 2017

    Thank you for coming back from the past to update us 5graces! Good to hear you are doing well. I assume your eyes are healthy now? My problem is my opthamologist says my eyes are healthy, really? But I have Fuch's disease (unrelated to Letrozole), PCO (scarring from my cataract surgery), PVD posterior Vitreous Detachment - that could be from normal aging and/or Aromatase Inhibitor treatment. Of course turning off the estrogen in your system speeds up aging. Now I have an ERM in one eye, floaters in both - a lot of floaters, I mean hundreds or more. ERM is some kind of wrinkling of the retina. No retina tearing thank goodness - it was a clean detachment, the doctor is so pleased about that - he said it was right over the optic nerve and that is a good thing. But then he went on to tell me it doesn't mean it's totally detached because it can detach in 10 places. So I'll be getting a lot of monitoring from now on. I think the fear of losing my eyesight is greater than the fear or recurrence. It's a choice of the better evil. Right now I'm off the letrozole and I also have pretty bad arthralgia since a change in the manufacturer of my letrozole from Roxane to Breckenridge. In just a few weeks the difference is pain is very notable. I used to say cataract surgery was one of the three best things that ever happened to me, however, apparently the surgery can cause scarring and the ERM I think. Need to double check that. All in all I am hoping for a better drug to come along. Psychologically I would rather be on the letrozole and doing all that I can. Who's got the answer here? No tamoxifen is not a choice, it may be worse than AI where the eyes are concerned.

    Sas, I see above you asked me for the whole story. So it's here and there is another forum AI and blurriness or something. Sorry didn't see your post before now. I've been on Letrozole since April 2015. Just a few months ago I was feeling pretty good......

  • 5graces
    5graces Member Posts: 99
    edited August 2017

    marijen, so sorry about all your vision problems......I have the fear that mine will get worse again this time on AI, as well. My mother had wet macular degeneration so I can certainly sympathize on that. She never got to have the injections because the desease was too far advanced when that treatment came out. I cared for her in my home until her death in 2012. Btw....my vision got much better after I stopped Femara the first time around, except for the cataracts so don't know what really to expect this time. And yes the anti hormone meds do speed up aging and I certainly don't need that at my age! :-)

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